ID   TCAR_STAAC              Reviewed;         151 AA.
AC   Q9F4G3; Q5HDJ8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=HTH-type transcriptional regulator TcaR;
GN   Name=tcaR; OrderedLocusNames=SACOL2353;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11042376; DOI=10.1016/s0304-4165(00)00133-1;
RA   Brandenberger M., Tschierske M., Giachino P., Wada A., Berger-Baechi B.;
RT   "Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB increases
RT   teicoplanin resistance in Staphylococcus aureus.";
RL   Biochim. Biophys. Acta 1523:135-139(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Involved in the antibiotic teicoplanin susceptibility.
CC       Inactivation of the tcaRAB operon leads to teicoplanin resistance (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Is a weak negative regulator of transcription of the icaABD
CC       operon. {ECO:0000250}.
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DR   EMBL; AY008833; AAG23887.1; -; Genomic_DNA.
DR   EMBL; CP000046; AAW37181.1; -; Genomic_DNA.
DR   PIR; H90035; H90035.
DR   RefSeq; WP_000238542.1; NC_002951.2.
DR   AlphaFoldDB; Q9F4G3; -.
DR   SMR; Q9F4G3; -.
DR   EnsemblBacteria; AAW37181; AAW37181; SACOL2353.
DR   KEGG; sac:SACOL2353; -.
DR   HOGENOM; CLU_1721241_0_0_9; -.
DR   OMA; LVEWDDC; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF12802; MarR_2; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..151
FT                   /note="HTH-type transcriptional regulator TcaR"
FT                   /id="PRO_0000054400"
FT   DOMAIN          1..142
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        54..77
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   151 AA;  17521 MW;  7FEFD9D39F2F6C53 CRC64;
     MVKHLQDHIQ FLEQFINNVN ALTAKMLKDL QNEYEISLEQ SNVLGMLNKE PLTISEITQR
     QGVNKAAVSR RIKKLIDAKL VKLDKPNLNI DQRLKFITLT DKGRAYLKER NAIMTDIAQD
     ITNDLNSEDI ENVRQVLEVI NHRIKTYSNH K