TCA_MOUSE
ID TCA_MOUSE Reviewed; 138 AA.
AC P01849;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=T-cell receptor alpha chain C region;
GN Name=Tcra;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE (CLONE PY14).
RC STRAIN=BALB.B;
RX PubMed=6208487; DOI=10.1038/312036a0;
RA Saito H., Kranz D.M., Takagaki Y., Hayday A.C., Eisen H.N., Tonegawa S.;
RT "A third rearranged and expressed gene in a clone of cytotoxic T
RT lymphocytes.";
RL Nature 312:36-40(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE (HYBRIDOMA 2B4).
RX PubMed=6548551; DOI=10.1038/312031a0;
RA Chien Y., Becker D.M., Lindsten T., Okamura M., Cohen D.I., Davis M.M.;
RT "A third type of murine T-cell receptor gene.";
RL Nature 312:31-35(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (HYBRIDOMA 2B4).
RX PubMed=8163944; DOI=10.1084/jem.179.5.1659;
RA Kuchroo V.K., Collins M., Al-Sabbagh A., Sobel R.A., Whitters M.J.,
RA Zamvil S.S., Dorf M.E., Hafler D.A., Seidman J.G., Weiner H.L., Rimm I.J.;
RT "T cell receptor (TCR) usage determines disease susceptibility in
RT experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2
RT transgenic mice.";
RL J. Exp. Med. 179:1659-1664(1994).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 2-138 (HYBRIDOMA 34S-281).
RX PubMed=2946043; DOI=10.1073/pnas.83.22.8708;
RA Imai K., Kanno M., Kimoto H., Shigemoto K., Yamamoto S., Taniguchi M.;
RT "Sequence and expression of transcripts of the T-cell antigen receptor
RT alpha-chain gene in a functional, antigen-specific suppressor-T-cell
RT hybridoma.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:8708-8712(1986).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Clone PHDS58 was isolated from a cytotoxic T lymphocyte.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA53226.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U07662; AAA53226.1; ALT_INIT; mRNA.
DR PIR; S25117; RWMSC8.
DR PDB; 1LP9; X-ray; 2.00 A; E/L=1-81.
DR PDB; 1NFD; X-ray; 2.80 A; A/C=2-92.
DR PDB; 2J8U; X-ray; 2.88 A; E/L=1-81.
DR PDB; 2JCC; X-ray; 2.50 A; E/L=1-81.
DR PDB; 2Q86; X-ray; 1.85 A; A/C=1-113.
DR PDB; 3C6L; X-ray; 3.40 A; A/E=1-78.
DR PDB; 3MBE; X-ray; 2.89 A; C/G=1-113.
DR PDB; 5M01; X-ray; 1.95 A; G=3-88.
DR PDB; 5M02; X-ray; 1.75 A; G=3-88.
DR PDB; 6G9Q; X-ray; 1.89 A; G=1-88.
DR PDB; 6MF8; NMR; -; A=93-138.
DR PDBsum; 1LP9; -.
DR PDBsum; 1NFD; -.
DR PDBsum; 2J8U; -.
DR PDBsum; 2JCC; -.
DR PDBsum; 2Q86; -.
DR PDBsum; 3C6L; -.
DR PDBsum; 3MBE; -.
DR PDBsum; 5M01; -.
DR PDBsum; 5M02; -.
DR PDBsum; 6G9Q; -.
DR PDBsum; 6MF8; -.
DR AlphaFoldDB; P01849; -.
DR BMRB; P01849; -.
DR SMR; P01849; -.
DR IntAct; P01849; 1.
DR GlyGen; P01849; 3 sites.
DR PhosphoSitePlus; P01849; -.
DR EPD; P01849; -.
DR PRIDE; P01849; -.
DR ABCD; P01849; 2 sequenced antibodies.
DR UCSC; uc007tub.2; mouse.
DR MGI; MGI:98553; Tcra.
DR InParanoid; P01849; -.
DR ChiTaRS; Tcra; mouse.
DR EvolutionaryTrace; P01849; -.
DR PRO; PR:P01849; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01849; protein.
DR GO; GO:0042105; C:alpha-beta T cell receptor complex; IDA:MGI.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051289; P:protein homotetramerization; IDA:MGI.
DR GO; GO:0009617; P:response to bacterium; IBA:GO_Central.
DR GO; GO:0002360; P:T cell lineage commitment; IMP:MGI.
DR CDD; cd07688; IgC_TCR_alpha; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015370; TCR_alpha_C.
DR Pfam; PF09291; DUF1968; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN <1..138
FT /note="T-cell receptor alpha chain C region"
FT /id="PRO_0000184525"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..112
FT /note="C segment"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 2
FT /note="Y -> D (in hybridoma 34S-281)"
FT VARIANT 2
FT /note="Y -> N (in hybridoma 2B4)"
FT NON_TER 1
FT STRAND 9..14
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 18..20
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 22..28
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 31..33
FT /evidence="ECO:0007829|PDB:5M01"
FT STRAND 40..42
FT /evidence="ECO:0007829|PDB:2JCC"
FT STRAND 43..45
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 49..53
FT /evidence="ECO:0007829|PDB:5M02"
FT TURN 54..57
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 58..68
FT /evidence="ECO:0007829|PDB:5M02"
FT HELIX 74..77
FT /evidence="ECO:0007829|PDB:5M02"
FT HELIX 109..125
FT /evidence="ECO:0007829|PDB:6MF8"
FT TURN 126..128
FT /evidence="ECO:0007829|PDB:6MF8"
FT HELIX 129..133
FT /evidence="ECO:0007829|PDB:6MF8"
SQ SEQUENCE 138 AA; 15495 MW; 984B77953AA80444 CRC64;
PYIQNPEPAV YQLKDPRSQD STLCLFTDFD SQINVPKTME SGTFITDKTV LDMKAMDSKS
NGAIAWSNQT SFTCQDIFKE TNATYPSSDV PCDATLTEKS FETDMNLNFQ NLSVMGLRIL
LLKVAGFNLL MTLRLWSS
