ID   TCB1_CAEBR              Reviewed;         273 AA.
AC   P35072;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Transposable element Tcb1 transposase;
DE   AltName: Full=Transposable element Barney transposase;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=G16;
RX   PubMed=2161057; DOI=10.1007/bf02101890;
RA   Harris L.J., Prasad S., Rose A.M.;
RT   "Isolation and sequence analysis of Caenorhabditis briggsae repetitive
RT   elements related to the Caenorhabditis elegans transposon Tc1.";
RL   J. Mol. Evol. 30:359-369(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=G16;
RX   PubMed=2840637; DOI=10.1093/nar/16.13.5991;
RA   Harris L.J., Baillie D.L., Rose A.M.;
RT   "Sequence identity between an inverted repeat family of transposable
RT   elements in Drosophila and Caenorhabditis.";
RL   Nucleic Acids Res. 16:5991-5998(1988).
CC   -!- FUNCTION: Probably essential for transposable element Tcb1
CC       transposition. The insertion of Tcb1 is the main cause of spontaneous
CC       mutations.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the transposase 5 family. {ECO:0000305}.
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DR   EMBL; X07827; CAA30681.1; -; Genomic_DNA.
DR   EMBL; X54218; CAA38131.1; -; Genomic_DNA.
DR   PIR; S01245; S01245.
DR   PIR; S15609; S15609.
DR   AlphaFoldDB; P35072; -.
DR   SMR; P35072; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   HOGENOM; CLU_351337_0_0_1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR038717; Tc1-like_DDE_dom.
DR   InterPro; IPR002492; Transposase_Tc1-like.
DR   Pfam; PF13358; DDE_3; 1.
DR   Pfam; PF01498; HTH_Tnp_Tc3_2; 1.
PE   3: Inferred from homology;
KW   DNA integration; DNA recombination; DNA-binding; Nucleus;
KW   Transposable element.
FT   CHAIN           1..273
FT                   /note="Transposable element Tcb1 transposase"
FT                   /id="PRO_0000072446"
SQ   SEQUENCE   273 AA;  31842 MW;  D67F08BFFA8F65C0 CRC64;
     MDRNILRACR EDPRRTSTDI QLSVTSPNEP VPSRRTIRRR LQVAGLHGRR PVKKPLVSLK
     NRKARVEWAK QHLSWGPREW ANHIWSDESK FNMFGTDGIQ WIRRPIGSRY APQYQCPTVK
     HGGGSVMVWG CFSDTSMGPL KRIVGTMDRY VYEDILENTM RPWARANLGR SWVFQQDNDP
     KHTSGHVANW FRRRRVNLLE WPSQSPDLNP IEHMWEELER RLKGVRASNA NQKFAQLEAA
     WKSIPMTVVQ TLLESMPRRC KAVIDAKGYP TKY