TCB1_MOUSE
ID TCB1_MOUSE Reviewed; 173 AA.
AC P01852;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=T-cell receptor beta-1 chain C region;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B10.A;
RX PubMed=6336329; DOI=10.1038/310387a0;
RA Gascoigne N.R.J., Chien Y., Becker D.M., Kavaler J., Davis M.M.;
RT "Genomic organization and sequence of T-cell receptor beta-chain
RT constant- and joining-region genes.";
RL Nature 310:387-391(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE (CLONE 86T1).
RX PubMed=6546606; DOI=10.1038/308153a0;
RA Hedrick S.M., Nielsen E.A., Kavaler J., Cohen D.I., Davis M.M.;
RT "Sequence relationships between putative T-cell receptor polypeptides and
RT immunoglobulins.";
RL Nature 308:153-158(1984).
RN [3]
RP PROTEIN SEQUENCE OF 19-26, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-126.
RX PubMed=9881971; DOI=10.1016/s1074-7613(00)80646-9;
RA Li H., Llera A., Tsuchiya D., Leder L., Ysern X., Schlievert P.M.,
RA Karjalainen K., Mariuzza R.A.;
RT "Three-dimensional structure of the complex between a T cell receptor beta
RT chain and the superantigen staphylococcal enterotoxin B.";
RL Immunity 9:807-816(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Clone B10.A was isolated from a cytotoxic T lymphocyte.
CC -!- MISCELLANEOUS: Clone 86T1 was isolated from a cytotoxic T lymphocyte.
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DR PIR; B93336; RWMS1C.
DR PDB; 1G6R; X-ray; 2.80 A; B/D=1-127.
DR PDB; 1NFD; X-ray; 2.80 A; B/D=1-127.
DR PDB; 1SBB; X-ray; 2.40 A; A/C=1-126.
DR PDB; 3C6L; X-ray; 3.40 A; B/F=1-126.
DR PDB; 3MBE; X-ray; 2.89 A; D/H=1-136.
DR PDB; 6G9Q; X-ray; 1.89 A; H=1-127.
DR PDBsum; 1G6R; -.
DR PDBsum; 1NFD; -.
DR PDBsum; 1SBB; -.
DR PDBsum; 3C6L; -.
DR PDBsum; 3MBE; -.
DR PDBsum; 6G9Q; -.
DR AlphaFoldDB; P01852; -.
DR SMR; P01852; -.
DR IntAct; P01852; 1.
DR GlyGen; P01852; 2 sites.
DR PhosphoSitePlus; P01852; -.
DR EPD; P01852; -.
DR MaxQB; P01852; -.
DR PRIDE; P01852; -.
DR ABCD; P01852; 1 sequenced antibody.
DR UCSC; uc009bok.1; mouse.
DR EvolutionaryTrace; P01852; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01852; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN <1..173
FT /note="T-cell receptor beta-1 chain C region"
FT /id="PRO_0000184527"
FT TRANSMEM 146..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..146
FT /note="C region"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 31..71
FT VARIANT 70
FT /note="Y -> H (in clone 86T1)"
FT NON_TER 1
FT HELIX 3..5
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 10..15
FT /evidence="ECO:0007829|PDB:6G9Q"
FT HELIX 18..24
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 25..39
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 41..47
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 63..66
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 69..79
FT /evidence="ECO:0007829|PDB:6G9Q"
FT HELIX 80..84
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 89..96
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 101..103
FT /evidence="ECO:0007829|PDB:1SBB"
FT STRAND 107..109
FT /evidence="ECO:0007829|PDB:6G9Q"
FT STRAND 115..122
FT /evidence="ECO:0007829|PDB:6G9Q"
SQ SEQUENCE 173 AA; 19346 MW; F9B4735E46D3E4D7 CRC64;
EDLRNVTPPK VSLFEPSKAE IANKQKATLV CLARGFFPDH VELSWWVNGK EVHSGVSTDP
QAYKESNYSY CLSSRLRVSA TFWHNPRNHF RCQVQFHGLS EEDKWPEGSP KPVTQNISAE
AWGRADCGIT SASYQQGVLS ATILYEILLG KATLYAVLVS TLVVMAMVKR KNS
