TCB2_MOUSE
ID TCB2_MOUSE Reviewed; 173 AA.
AC P01851;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=T-cell receptor beta-2 chain C region;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=B10.A;
RX PubMed=6336329; DOI=10.1038/310387a0;
RA Gascoigne N.R.J., Chien Y., Becker D.M., Kavaler J., Davis M.M.;
RT "Genomic organization and sequence of T-cell receptor beta-chain
RT constant- and joining-region genes.";
RL Nature 310:387-391(1984).
RN [2]
RP NUCLEOTIDE SEQUENCE (CLONE 2C).
RC STRAIN=BALB.B;
RX PubMed=6330561; DOI=10.1038/309757a0;
RA Saito H., Kranz D.M., Takagaki Y., Hayday A.C., Eisen H.N., Tonegawa S.;
RT "Complete primary structure of a heterodimeric T-cell receptor deduced from
RT cDNA sequences.";
RL Nature 309:757-762(1984).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-124.
RX PubMed=12015151; DOI=10.1016/s0969-2126(02)00759-1;
RA Sundberg E.J., Li H., Llera A.S., McCormick J.K., Tormo J.,
RA Schlievert P.M., Karjalainen K., Mariuzza R.A.;
RT "Structures of two streptococcal superantigens bound to TCR beta chains
RT reveal diversity in the architecture of T cell signaling complexes.";
RL Structure 10:687-699(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Clone B10.A was isolated from a cytotoxic T lymphocyte.
CC -!- MISCELLANEOUS: Clone 2C was isolated from a cytotoxic T lymphocyte.
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DR PDB; 1L0X; X-ray; 2.80 A; A/C=1-126.
DR PDB; 1L0Y; X-ray; 2.50 A; A/C=1-124.
DR PDB; 1MWA; X-ray; 2.40 A; B/D=1-127.
DR PDB; 2Q86; X-ray; 1.85 A; B/D=1-141.
DR PDB; 5M01; X-ray; 1.95 A; H=1-127.
DR PDB; 5M02; X-ray; 1.75 A; H=1-127.
DR PDBsum; 1L0X; -.
DR PDBsum; 1L0Y; -.
DR PDBsum; 1MWA; -.
DR PDBsum; 2Q86; -.
DR PDBsum; 5M01; -.
DR PDBsum; 5M02; -.
DR AlphaFoldDB; P01851; -.
DR SMR; P01851; -.
DR IntAct; P01851; 1.
DR MINT; P01851; -.
DR GlyGen; P01851; 2 sites.
DR PhosphoSitePlus; P01851; -.
DR MaxQB; P01851; -.
DR PRIDE; P01851; -.
DR EvolutionaryTrace; P01851; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P01851; protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0042571; C:immunoglobulin complex, circulating; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0003823; F:antigen binding; IBA:GO_Central.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IBA:GO_Central.
DR GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006958; P:complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0006910; P:phagocytosis, recognition; IBA:GO_Central.
DR GO; GO:0050871; P:positive regulation of B cell activation; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR Pfam; PF07654; C1-set; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN <1..173
FT /note="T-cell receptor beta-2 chain C region"
FT /id="PRO_0000184528"
FT TRANSMEM 147..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..146
FT /note="C region"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 50
FT /note="K -> R (in clone 2C)"
FT VARIANT 70
FT /note="Y -> H (in clone 2C)"
FT NON_TER 1
FT HELIX 3..5
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 10..15
FT /evidence="ECO:0007829|PDB:5M02"
FT HELIX 18..24
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 25..38
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 41..47
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 56..58
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 63..66
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 69..79
FT /evidence="ECO:0007829|PDB:5M02"
FT HELIX 80..83
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 89..96
FT /evidence="ECO:0007829|PDB:5M02"
FT STRAND 101..103
FT /evidence="ECO:0007829|PDB:1L0X"
FT STRAND 107..109
FT /evidence="ECO:0007829|PDB:2Q86"
FT STRAND 113..122
FT /evidence="ECO:0007829|PDB:5M02"
SQ SEQUENCE 173 AA; 19297 MW; A5458149614CF295 CRC64;
EDLRNVTPPK VSLFEPSKAE IANKQKATLV CLARGFFPDH VELSWWVNGK EVHSGVSTDP
QAYKESNYSY CLSSRLRVSA TFWHNPRNHF RCQVQFHGLS EEDKWPEGSP KPVTQNISAE
AWGRADCGIT SASYHQGVLS ATILYEILLG KATLYAVLVS GLVLMAMVKK KNS
