ID   TCBR_PSESQ              Reviewed;         294 AA.
AC   P27102;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=HTH-type transcriptional regulator TcbR;
DE   AltName: Full=TcbCDEF operon positive regulator;
GN   Name=tcbR;
OS   Pseudomonas sp. (strain P51).
OG   Plasmid pP51.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae.
OX   NCBI_TaxID=65067;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2050630; DOI=10.1128/jb.173.12.3700-3708.1991;
RA   van der Meer J.R., Frijters A.C., Leveau J.H., Eggen R.I., Zehnder A.J.,
RA   de Vos W.M.;
RT   "Characterization of the Pseudomonas sp. strain P51 gene tcbR, a LysR-type
RT   transcriptional activator of the tcbCDEF chlorocatechol oxidative operon,
RT   and analysis of the regulatory region.";
RL   J. Bacteriol. 173:3700-3708(1991).
CC   -!- FUNCTION: Involved in regulation of chlorinated catechol metabolism.
CC       Transcriptional activator of the tcbCDEF chlorocatechol oxidative
CC       operon. May bind 2-chloromuconate as an inducer.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M80212; AAA25993.1; -; Genomic_DNA.
DR   EMBL; M57629; AAD13624.1; -; Genomic_DNA.
DR   PIR; A38861; A38861.
DR   AlphaFoldDB; P27102; -.
DR   SMR; P27102; -.
DR   PRIDE; P27102; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; Aromatic hydrocarbons catabolism; DNA-binding; Plasmid;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..294
FT                   /note="HTH-type transcriptional regulator TcbR"
FT                   /id="PRO_0000105756"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   294 AA;  32025 MW;  C67E6B78E50DAACB CRC64;
     MEFRQLKYFI AVAEAGNMAA AAKRLHVSQP PITRQMQALE ADLGVVLLER SHRGIELTAA
     GHAFLEDARR ILELAGRSGD RSRAAARGDV GELSVAYFGT PIYRSLPLLL RAFLTSTPTA
     TVSLTHMTKD EQVEGLLAGT IHVGFSRFFP RHPGIEIVNI AQEDLYLAVH RSQSGKFGKT
     CKLADLRAVE LTLFPRGGRP SFADEVIGLF KHAGIEPRIA RVVEDATAAL ALTMAGAASS
     IVPASVAAIR WPDIAFARIV GTRVKVPISC TFRKEKQPPI LARFVEHVRR SAKD