TCEA2_HUMAN
ID TCEA2_HUMAN Reviewed; 299 AA.
AC Q15560; B3KNM1; Q8TD37; Q8TD38;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 195.
DE RecName: Full=Transcription elongation factor A protein 2;
DE AltName: Full=Testis-specific S-II;
DE AltName: Full=Transcription elongation factor S-II protein 2;
DE AltName: Full=Transcription elongation factor TFIIS.l;
GN Name=TCEA2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND INTERACTION
RP WITH GTF2B.
RX PubMed=8566795; DOI=10.1016/0378-1119(95)00634-6;
RA Umehara T., Kida S., Yamamoto T., Horikoshi M.;
RT "Isolation and characterization of a cDNA encoding a new type of human
RT transcription elongation factor S-II.";
RL Gene 167:297-302(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
RC TISSUE=Brain;
RX PubMed=9441762; DOI=10.1006/geno.1997.5073;
RA Weaver Z.A., Kane C.M.;
RT "Genomic characterization of a testis-specific TFIIS (TCEA2) gene.";
RL Genomics 46:516-519(1997).
RN [6]
RP FUNCTION.
RX PubMed=12034815; DOI=10.1093/nar/30.11.2290;
RA Sijbrandi R., Fiedler U., Timmers H.T.M.;
RT "RNA polymerase II complexes in the very early phase of transcription are
RT not susceptible to TFIIS-induced exonucleolytic cleavage.";
RL Nucleic Acids Res. 30:2290-2298(2002).
RN [7]
RP INTERACTION WITH REXO1.
RX PubMed=12943681; DOI=10.1016/s0006-291x(03)01556-0;
RA Tamura K., Miyata K., Sugahara K., Onishi S., Shuin T., Aso T.;
RT "Identification of EloA-BP1, a novel Elongin A binding protein with an
RT exonuclease homology domain.";
RL Biochem. Biophys. Res. Commun. 309:189-195(2003).
RN [8]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-58, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=18655026; DOI=10.1002/pmic.200700887;
RA Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J.,
RA Luo Y., Qiang B., Yuan J., Sun X., Peng X.;
RT "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell
RT line Chang liver cells.";
RL Proteomics 8:2885-2896(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Necessary for efficient RNA polymerase II transcription
CC elongation past template-encoded arresting sites. The arresting sites
CC in DNA have the property of trapping a certain fraction of elongating
CC RNA polymerases that pass through, resulting in locked ternary
CC complexes. Cleavage of the nascent transcript by S-II allows the
CC resumption of elongation from the new 3'-terminus.
CC {ECO:0000269|PubMed:12034815}.
CC -!- SUBUNIT: Interacts with the basal transcription factor GTF2B. Interacts
CC with REXO1. {ECO:0000269|PubMed:12943681, ECO:0000269|PubMed:8566795}.
CC -!- INTERACTION:
CC Q15560; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-710310, EBI-10173507;
CC Q15560; O95994: AGR2; NbExp=3; IntAct=EBI-710310, EBI-712648;
CC Q15560; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-710310, EBI-11522760;
CC Q15560; P13196: ALAS1; NbExp=3; IntAct=EBI-710310, EBI-3905054;
CC Q15560; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-710310, EBI-746752;
CC Q15560; Q8N2F6-2: ARMC10; NbExp=3; IntAct=EBI-710310, EBI-12902762;
CC Q15560; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-710310, EBI-4400025;
CC Q15560; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-710310, EBI-1642333;
CC Q15560; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-710310, EBI-11519926;
CC Q15560; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-710310, EBI-11975051;
CC Q15560; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-710310, EBI-11983447;
CC Q15560; Q96KE9-2: BTBD6; NbExp=3; IntAct=EBI-710310, EBI-12012762;
CC Q15560; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-710310, EBI-11524851;
CC Q15560; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-710310, EBI-10171416;
CC Q15560; Q569K6: CCDC157; NbExp=3; IntAct=EBI-710310, EBI-13289565;
CC Q15560; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-710310, EBI-744115;
CC Q15560; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-710310, EBI-742887;
CC Q15560; Q8IZR5-2: CMTM4; NbExp=3; IntAct=EBI-710310, EBI-17278014;
CC Q15560; Q9NX76: CMTM6; NbExp=3; IntAct=EBI-710310, EBI-1054315;
CC Q15560; Q8N137: CNTROB; NbExp=3; IntAct=EBI-710310, EBI-947360;
CC Q15560; Q5RI15: COX20; NbExp=3; IntAct=EBI-710310, EBI-2834035;
CC Q15560; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-710310, EBI-3867333;
CC Q15560; O75553: DAB1; NbExp=3; IntAct=EBI-710310, EBI-7875264;
CC Q15560; P17661: DES; NbExp=3; IntAct=EBI-710310, EBI-1055572;
CC Q15560; Q92997: DVL3; NbExp=3; IntAct=EBI-710310, EBI-739789;
CC Q15560; Q96JC9: EAF1; NbExp=3; IntAct=EBI-710310, EBI-769261;
CC Q15560; Q96CJ1: EAF2; NbExp=3; IntAct=EBI-710310, EBI-1245604;
CC Q15560; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-710310, EBI-371922;
CC Q15560; Q13158: FADD; NbExp=3; IntAct=EBI-710310, EBI-494804;
CC Q15560; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-710310, EBI-10175124;
CC Q15560; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-710310, EBI-11977403;
CC Q15560; P51114-2: FXR1; NbExp=3; IntAct=EBI-710310, EBI-11022345;
CC Q15560; O95995: GAS8; NbExp=3; IntAct=EBI-710310, EBI-1052570;
CC Q15560; O75420: GIGYF1; NbExp=3; IntAct=EBI-710310, EBI-947774;
CC Q15560; Q08379: GOLGA2; NbExp=6; IntAct=EBI-710310, EBI-618309;
CC Q15560; Q92917: GPKOW; NbExp=7; IntAct=EBI-710310, EBI-746309;
CC Q15560; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-710310, EBI-717919;
CC Q15560; Q9BYE0: HES7; NbExp=3; IntAct=EBI-710310, EBI-12163087;
CC Q15560; A8MV81: HIGD1C; NbExp=3; IntAct=EBI-710310, EBI-12809676;
CC Q15560; O00291: HIP1; NbExp=3; IntAct=EBI-710310, EBI-473886;
CC Q15560; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-710310, EBI-2549423;
CC Q15560; O75031: HSF2BP; NbExp=3; IntAct=EBI-710310, EBI-7116203;
CC Q15560; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-710310, EBI-11522367;
CC Q15560; Q9H2S9: IKZF4; NbExp=3; IntAct=EBI-710310, EBI-1640423;
CC Q15560; Q9H3M0: KCNF1; NbExp=3; IntAct=EBI-710310, EBI-6918743;
CC Q15560; Q9H3F6: KCTD10; NbExp=3; IntAct=EBI-710310, EBI-2505886;
CC Q15560; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-710310, EBI-11954971;
CC Q15560; Q8N8K9: KIAA1958; NbExp=6; IntAct=EBI-710310, EBI-10181113;
CC Q15560; Q6A162: KRT40; NbExp=3; IntAct=EBI-710310, EBI-10171697;
CC Q15560; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-710310, EBI-10172290;
CC Q15560; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-710310, EBI-10171774;
CC Q15560; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-710310, EBI-10176379;
CC Q15560; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-710310, EBI-11953334;
CC Q15560; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-710310, EBI-3958099;
CC Q15560; Q9BQD3: KXD1; NbExp=3; IntAct=EBI-710310, EBI-739657;
CC Q15560; P48059-3: LIMS1; NbExp=3; IntAct=EBI-710310, EBI-12864460;
CC Q15560; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-710310, EBI-1216080;
CC Q15560; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-710310, EBI-741037;
CC Q15560; P43364: MAGEA11; NbExp=5; IntAct=EBI-710310, EBI-739552;
CC Q15560; P27448: MARK3; NbExp=2; IntAct=EBI-710310, EBI-707595;
CC Q15560; P23508: MCC; NbExp=3; IntAct=EBI-710310, EBI-307531;
CC Q15560; P21741: MDK; NbExp=3; IntAct=EBI-710310, EBI-722444;
CC Q15560; P50222: MEOX2; NbExp=3; IntAct=EBI-710310, EBI-748397;
CC Q15560; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-710310, EBI-16439278;
CC Q15560; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-710310, EBI-10172526;
CC Q15560; Q13064: MKRN3; NbExp=3; IntAct=EBI-710310, EBI-2340269;
CC Q15560; Q8NCY6: MSANTD4; NbExp=3; IntAct=EBI-710310, EBI-7850168;
CC Q15560; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-710310, EBI-11522433;
CC Q15560; Q15742: NAB2; NbExp=3; IntAct=EBI-710310, EBI-8641936;
CC Q15560; Q8N987: NECAB1; NbExp=3; IntAct=EBI-710310, EBI-11956853;
CC Q15560; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-710310, EBI-10172876;
CC Q15560; Q9H4L5: OSBPL3; NbExp=3; IntAct=EBI-710310, EBI-1051317;
CC Q15560; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-710310, EBI-14066006;
CC Q15560; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-710310, EBI-79165;
CC Q15560; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-710310, EBI-10232538;
CC Q15560; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-710310, EBI-302345;
CC Q15560; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-710310, EBI-10171633;
CC Q15560; P78424: POU6F2; NbExp=3; IntAct=EBI-710310, EBI-12029004;
CC Q15560; P41219: PRPH; NbExp=3; IntAct=EBI-710310, EBI-752074;
CC Q15560; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-710310, EBI-740343;
CC Q15560; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-710310, EBI-10192441;
CC Q15560; Q96KG9-4: SCYL1; NbExp=3; IntAct=EBI-710310, EBI-12023020;
CC Q15560; A1L4H1: SSC5D; NbExp=3; IntAct=EBI-710310, EBI-10172867;
CC Q15560; Q96MF2: STAC3; NbExp=3; IntAct=EBI-710310, EBI-745680;
CC Q15560; O75558: STX11; NbExp=3; IntAct=EBI-710310, EBI-714135;
CC Q15560; Q8N205-2: SYNE4; NbExp=3; IntAct=EBI-710310, EBI-12099160;
CC Q15560; Q15633: TARBP2; NbExp=3; IntAct=EBI-710310, EBI-978581;
CC Q15560; Q86VP1: TAX1BP1; NbExp=3; IntAct=EBI-710310, EBI-529518;
CC Q15560; Q86TI0: TBC1D1; NbExp=3; IntAct=EBI-710310, EBI-1644036;
CC Q15560; P15884: TCF4; NbExp=3; IntAct=EBI-710310, EBI-533224;
CC Q15560; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-710310, EBI-11139477;
CC Q15560; Q12800: TFCP2; NbExp=3; IntAct=EBI-710310, EBI-717422;
CC Q15560; Q9NVV9: THAP1; NbExp=6; IntAct=EBI-710310, EBI-741515;
CC Q15560; Q6P5X7-2: TMEM71; NbExp=3; IntAct=EBI-710310, EBI-12886878;
CC Q15560; Q15025: TNIP1; NbExp=8; IntAct=EBI-710310, EBI-357849;
CC Q15560; Q96NM4-3: TOX2; NbExp=3; IntAct=EBI-710310, EBI-12815137;
CC Q15560; Q13077: TRAF1; NbExp=3; IntAct=EBI-710310, EBI-359224;
CC Q15560; Q12933: TRAF2; NbExp=7; IntAct=EBI-710310, EBI-355744;
CC Q15560; P36406: TRIM23; NbExp=3; IntAct=EBI-710310, EBI-740098;
CC Q15560; P14373: TRIM27; NbExp=6; IntAct=EBI-710310, EBI-719493;
CC Q15560; O00635: TRIM38; NbExp=3; IntAct=EBI-710310, EBI-2130415;
CC Q15560; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-710310, EBI-725997;
CC Q15560; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-710310, EBI-2130429;
CC Q15560; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-710310, EBI-744794;
CC Q15560; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-710310, EBI-11975223;
CC Q15560; P08670: VIM; NbExp=3; IntAct=EBI-710310, EBI-353844;
CC Q15560; O15209: ZBTB22; NbExp=3; IntAct=EBI-710310, EBI-723574;
CC Q15560; O43298: ZBTB43; NbExp=3; IntAct=EBI-710310, EBI-740718;
CC Q15560; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-710310, EBI-742740;
CC Q15560; Q96C00: ZBTB9; NbExp=3; IntAct=EBI-710310, EBI-395708;
CC Q15560; Q15776: ZKSCAN8; NbExp=3; IntAct=EBI-710310, EBI-2602314;
CC Q15560; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-710310, EBI-11035148;
CC Q15560; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-710310, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q15560-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15560-2; Sequence=VSP_047345;
CC -!- TISSUE SPECIFICITY: Testis and ovary specific.
CC {ECO:0000269|PubMed:8566795}.
CC -!- SIMILARITY: Belongs to the TFS-II family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator.
CC {ECO:0000305}.
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DR EMBL; D50495; BAA09089.1; -; mRNA.
DR EMBL; AK027824; BAG51383.1; -; mRNA.
DR EMBL; AL590548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018896; AAH18896.1; -; mRNA.
DR EMBL; U86749; AAC39553.1; -; Genomic_DNA.
DR CCDS; CCDS13553.1; -. [Q15560-1]
DR CCDS; CCDS13554.1; -. [Q15560-2]
DR PIR; JC4577; JC4577.
DR RefSeq; NP_003186.1; NM_003195.5. [Q15560-1]
DR RefSeq; NP_942016.1; NM_198723.2. [Q15560-2]
DR RefSeq; XP_016883525.1; XM_017028036.1.
DR RefSeq; XP_016883526.1; XM_017028037.1.
DR PDB; 2LW4; NMR; -; A=130-239.
DR PDBsum; 2LW4; -.
DR AlphaFoldDB; Q15560; -.
DR BMRB; Q15560; -.
DR SMR; Q15560; -.
DR BioGRID; 112781; 157.
DR IntAct; Q15560; 129.
DR MINT; Q15560; -.
DR STRING; 9606.ENSP00000343515; -.
DR GlyGen; Q15560; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q15560; -.
DR PhosphoSitePlus; Q15560; -.
DR BioMuta; TCEA2; -.
DR DMDM; 28380177; -.
DR EPD; Q15560; -.
DR jPOST; Q15560; -.
DR MassIVE; Q15560; -.
DR MaxQB; Q15560; -.
DR PaxDb; Q15560; -.
DR PeptideAtlas; Q15560; -.
DR PRIDE; Q15560; -.
DR ProteomicsDB; 60633; -. [Q15560-1]
DR Antibodypedia; 15504; 132 antibodies from 18 providers.
DR DNASU; 6919; -.
DR Ensembl; ENST00000343484.10; ENSP00000343515.5; ENSG00000171703.17. [Q15560-1]
DR Ensembl; ENST00000361317.6; ENSP00000354552.2; ENSG00000171703.17. [Q15560-2]
DR GeneID; 6919; -.
DR KEGG; hsa:6919; -.
DR MANE-Select; ENST00000343484.10; ENSP00000343515.5; NM_003195.6; NP_003186.1.
DR UCSC; uc061yqt.1; human. [Q15560-1]
DR CTD; 6919; -.
DR DisGeNET; 6919; -.
DR GeneCards; TCEA2; -.
DR HGNC; HGNC:11614; TCEA2.
DR HPA; ENSG00000171703; Low tissue specificity.
DR MalaCards; TCEA2; -.
DR MIM; 604784; gene.
DR neXtProt; NX_Q15560; -.
DR OpenTargets; ENSG00000171703; -.
DR PharmGKB; PA36373; -.
DR VEuPathDB; HostDB:ENSG00000171703; -.
DR eggNOG; KOG1105; Eukaryota.
DR GeneTree; ENSGT00940000159974; -.
DR HOGENOM; CLU_037637_2_0_1; -.
DR InParanoid; Q15560; -.
DR OMA; KMVTRKS; -.
DR PhylomeDB; Q15560; -.
DR TreeFam; TF314970; -.
DR PathwayCommons; Q15560; -.
DR SignaLink; Q15560; -.
DR BioGRID-ORCS; 6919; 35 hits in 1081 CRISPR screens.
DR GeneWiki; TCEA2; -.
DR GenomeRNAi; 6919; -.
DR Pharos; Q15560; Tbio.
DR PRO; PR:Q15560; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q15560; protein.
DR Bgee; ENSG00000171703; Expressed in right hemisphere of cerebellum and 175 other tissues.
DR ExpressionAtlas; Q15560; baseline and differential.
DR Genevisible; Q15560; HS.
DR GO; GO:0005813; C:centrosome; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008023; C:transcription elongation factor complex; NAS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006354; P:DNA-templated transcription, elongation; NAS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; NAS:UniProtKB.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.472.30; -; 1.
DR Gene3D; 1.20.930.10; -; 1.
DR InterPro; IPR035100; TF_IIS-typ.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR InterPro; IPR006289; TFSII.
DR InterPro; IPR001222; Znf_TFIIS.
DR Pfam; PF08711; Med26; 1.
DR Pfam; PF01096; TFIIS_C; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR PIRSF; PIRSF006704; TF_IIS; 1.
DR SMART; SM00510; TFS2M; 1.
DR SMART; SM00509; TFS2N; 1.
DR SMART; SM00440; ZnF_C2C2; 1.
DR SUPFAM; SSF46942; SSF46942; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR TIGRFAMs; TIGR01385; TFSII; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
DR PROSITE; PS00466; ZF_TFIIS_1; 1.
DR PROSITE; PS51133; ZF_TFIIS_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; DNA-binding; Isopeptide bond;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..299
FT /note="Transcription elongation factor A protein 2"
FT /id="PRO_0000121449"
FT DOMAIN 6..83
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00649"
FT DOMAIN 138..254
FT /note="TFIIS central"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00651"
FT ZN_FING 257..297
FT /note="TFIIS-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT REGION 86..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 261
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT BINDING 264
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT BINDING 289
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT BINDING 292
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00472"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23193"
FT MOD_RES 100
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23193"
FT CROSSLNK 58
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000269|PubMed:18655026"
FT VAR_SEQ 1..27
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047345"
FT CONFLICT 55
FT /note="A -> T (in Ref. 2; BAG51383)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="E -> V (in Ref. 2; BAG51383)"
FT /evidence="ECO:0000305"
FT HELIX 139..151
FT /evidence="ECO:0007829|PDB:2LW4"
FT HELIX 155..159
FT /evidence="ECO:0007829|PDB:2LW4"
FT HELIX 163..178
FT /evidence="ECO:0007829|PDB:2LW4"
FT TURN 181..183
FT /evidence="ECO:0007829|PDB:2LW4"
FT HELIX 184..197
FT /evidence="ECO:0007829|PDB:2LW4"
FT STRAND 199..202
FT /evidence="ECO:0007829|PDB:2LW4"
FT HELIX 203..209
FT /evidence="ECO:0007829|PDB:2LW4"
FT HELIX 215..220
FT /evidence="ECO:0007829|PDB:2LW4"
FT HELIX 223..227
FT /evidence="ECO:0007829|PDB:2LW4"
FT TURN 229..233
FT /evidence="ECO:0007829|PDB:2LW4"
FT STRAND 235..237
FT /evidence="ECO:0007829|PDB:2LW4"
SQ SEQUENCE 299 AA; 33601 MW; FF0EAE8EDC7BCBE9 CRC64;
MMGKEEEIAR IARRLDKMVT KKSAEGAMDL LRELKAMPIT LHLLQSTRVG MSVNALRKQS
SDEEVIALAK SLIKSWKKLL DASDAKARER GRGMPLPTSS RDASEAPDPS RKRPELPRAP
STPRITTFPP VPVTCDAVRN KCREMLTAAL QTDHDHVAIG ADCERLSAQI EECIFRDVGN
TDMKYKNRVR SRISNLKDAK NPDLRRNVLC GAITPQQIAV MTSEEMASDE LKEIRKAMTK
EAIREHQMAR TGGTQTDLFT CGKCRKKNCT YTQVQTRSSD EPMTTFVVCN ECGNRWKFC
