TCF19_HUMAN
ID TCF19_HUMAN Reviewed; 345 AA.
AC Q9Y242; A6NCT8; B0UY11; Q0EFA8; Q13176; Q15967; Q5SQ89; Q5STD6; Q5STF5;
AC Q9BUM2; Q9UBH7;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Transcription factor 19;
DE Short=TCF-19;
DE AltName: Full=Transcription factor SC1;
GN Name=TCF19; Synonyms=SC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-211.
RC TISSUE=Blood;
RX PubMed=1868030;
RA Ku D.H., Chang C.D., Koniecki J., Cannizzaro L.A., Boghosian-Sell L.,
RA Alder H., Baserga R.;
RT "A new growth-regulated complementary DNA with the sequence of a putative
RT trans-activating factor.";
RL Cell Growth Differ. 2:179-186(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-211 AND LEU-241.
RX PubMed=10777095; DOI=10.1034/j.1399-0039.2000.550303.x;
RA Teraoka Y., Naruse T.K., Oka A., Matsuzawa Y., Shiina T., Iizuka M.,
RA Iwashita K., Ozawa A., Inoko H.;
RT "Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of
RT the HLA-C gene and lack of association of psoriasis vulgaris.";
RL Tissue Antigens 55:206-211(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-211.
RC TISSUE=Blood;
RA Krishnan R.;
RT "Molecular mapping by transposon-based nested deletion sequencing: the SC1
RT gene maps near the HLA-C locus.";
RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-211.
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-211.
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-211 AND LEU-241.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS SER-109 AND
RP VAL-211.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-211 AND LEU-241.
RC TISSUE=Brain, Colon, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
CC -!- FUNCTION: Potential trans-activating factor that could play an
CC important role in the transcription of genes required for the later
CC stages of cell cycle progression.
CC -!- INTERACTION:
CC Q9Y242; Q9H2G9: BLZF1; NbExp=7; IntAct=EBI-7413767, EBI-2548012;
CC Q9Y242; Q8TAP6: CEP76; NbExp=3; IntAct=EBI-7413767, EBI-742887;
CC Q9Y242; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-7413767, EBI-742054;
CC Q9Y242; Q08379: GOLGA2; NbExp=5; IntAct=EBI-7413767, EBI-618309;
CC Q9Y242; P49639: HOXA1; NbExp=3; IntAct=EBI-7413767, EBI-740785;
CC Q9Y242; O75031: HSF2BP; NbExp=3; IntAct=EBI-7413767, EBI-7116203;
CC Q9Y242; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-7413767, EBI-10271199;
CC Q9Y242; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-7413767, EBI-12025760;
CC Q9Y242; Q9NR12: PDLIM7; NbExp=3; IntAct=EBI-7413767, EBI-350517;
CC Q9Y242; Q99471: PFDN5; NbExp=3; IntAct=EBI-7413767, EBI-357275;
CC Q9Y242; O43741: PRKAB2; NbExp=3; IntAct=EBI-7413767, EBI-1053424;
CC Q9Y242; Q15669: RHOH; NbExp=3; IntAct=EBI-7413767, EBI-1244971;
CC Q9Y242; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-7413767, EBI-492476;
CC Q9Y242; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-7413767, EBI-10183064;
CC Q9Y242; Q6S9Z5: ZNF474; NbExp=3; IntAct=EBI-7413767, EBI-17269964;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Growth regulated.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB60363.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; S53374; AAB19475.2; ALT_FRAME; mRNA.
DR EMBL; AB029516; BAA82324.1; -; Genomic_DNA.
DR EMBL; AB029517; BAA82325.1; -; Genomic_DNA.
DR EMBL; AB029518; BAA82326.1; -; Genomic_DNA.
DR EMBL; AB029519; BAA82327.1; -; Genomic_DNA.
DR EMBL; U25826; AAB60363.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BA000025; BAB63312.1; -; Genomic_DNA.
DR EMBL; AB088113; BAC54945.1; -; Genomic_DNA.
DR EMBL; AB103619; BAF31280.1; -; Genomic_DNA.
DR EMBL; AB202105; BAE78629.1; -; Genomic_DNA.
DR EMBL; BT007247; AAP35911.1; -; mRNA.
DR EMBL; AL662833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL773544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX088580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR847794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03363.1; -; Genomic_DNA.
DR EMBL; BC002493; AAH02493.1; -; mRNA.
DR EMBL; BC033086; AAH33086.1; -; mRNA.
DR EMBL; BC044632; AAH44632.1; -; mRNA.
DR CCDS; CCDS43446.1; -.
DR PIR; A61188; A61188.
DR RefSeq; NP_001070979.1; NM_001077511.1.
DR RefSeq; NP_001305837.1; NM_001318908.1.
DR RefSeq; NP_009040.2; NM_007109.2.
DR AlphaFoldDB; Q9Y242; -.
DR SMR; Q9Y242; -.
DR BioGRID; 112801; 29.
DR IntAct; Q9Y242; 25.
DR MINT; Q9Y242; -.
DR STRING; 9606.ENSP00000365433; -.
DR iPTMnet; Q9Y242; -.
DR PhosphoSitePlus; Q9Y242; -.
DR BioMuta; TCF19; -.
DR DMDM; 126302606; -.
DR jPOST; Q9Y242; -.
DR MassIVE; Q9Y242; -.
DR MaxQB; Q9Y242; -.
DR PaxDb; Q9Y242; -.
DR PeptideAtlas; Q9Y242; -.
DR PRIDE; Q9Y242; -.
DR ProteomicsDB; 85640; -.
DR Antibodypedia; 26851; 229 antibodies from 35 providers.
DR DNASU; 6941; -.
DR Ensembl; ENST00000376255.4; ENSP00000365431.4; ENSG00000137310.12.
DR Ensembl; ENST00000376257.8; ENSP00000365433.3; ENSG00000137310.12.
DR GeneID; 6941; -.
DR KEGG; hsa:6941; -.
DR MANE-Select; ENST00000376257.8; ENSP00000365433.3; NM_007109.3; NP_009040.2.
DR UCSC; uc003nss.4; human.
DR CTD; 6941; -.
DR DisGeNET; 6941; -.
DR GeneCards; TCF19; -.
DR HGNC; HGNC:11629; TCF19.
DR HPA; ENSG00000137310; Low tissue specificity.
DR MIM; 600912; gene.
DR neXtProt; NX_Q9Y242; -.
DR OpenTargets; ENSG00000137310; -.
DR PharmGKB; PA36384; -.
DR VEuPathDB; HostDB:ENSG00000137310; -.
DR eggNOG; ENOG502RHCY; Eukaryota.
DR GeneTree; ENSGT00390000015391; -.
DR HOGENOM; CLU_041089_0_0_1; -.
DR InParanoid; Q9Y242; -.
DR OMA; SGAGCTY; -.
DR OrthoDB; 1106192at2759; -.
DR PhylomeDB; Q9Y242; -.
DR TreeFam; TF334697; -.
DR PathwayCommons; Q9Y242; -.
DR SignaLink; Q9Y242; -.
DR BioGRID-ORCS; 6941; 12 hits in 1080 CRISPR screens.
DR ChiTaRS; TCF19; human.
DR GeneWiki; TCF19; -.
DR GenomeRNAi; 6941; -.
DR Pharos; Q9Y242; Tbio.
DR PRO; PR:Q9Y242; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9Y242; protein.
DR Bgee; ENSG00000137310; Expressed in ventricular zone and 99 other tissues.
DR ExpressionAtlas; Q9Y242; baseline and differential.
DR Genevisible; Q9Y242; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd00060; FHA; 1.
DR CDD; cd15609; PHD_TCF19; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR042803; TCF19.
DR InterPro; IPR039095; TCF19_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15464; PTHR15464; 2.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..345
FT /note="Transcription factor 19"
FT /id="PRO_0000059327"
FT DOMAIN 31..88
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT ZN_FING 296..339
FT /note="PHD-type"
FT REGION 190..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 78
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT VARIANT 109
FT /note="P -> S (in dbSNP:rs7750641)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_051604"
FT VARIANT 211
FT /note="M -> V (in dbSNP:rs2073721)"
FT /evidence="ECO:0000269|PubMed:10777095,
FT ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:16702430, ECO:0000269|PubMed:1868030,
FT ECO:0000269|Ref.3, ECO:0000269|Ref.4, ECO:0000269|Ref.6"
FT /id="VAR_017741"
FT VARIANT 241
FT /note="P -> L (in dbSNP:rs2073724)"
FT /evidence="ECO:0000269|PubMed:10777095,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.6"
FT /id="VAR_017742"
FT CONFLICT 27
FT /note="A -> V (in Ref. 3; AAB60363)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="Q -> N (in Ref. 1; AAB19475)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="S -> T (in Ref. 1; AAB19475)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="R -> A (in Ref. 3; AAB60363)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 37184 MW; B5730936A842B83A CRC64;
MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP GLISGIHAEL
HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYFM
FQQVRVKPQD FAAITIPRSR GEARVGAGFR PMLPSQGAPQ RPLSTFSPAP KATLILNSIG
SLSKLRPQPL TFSPSWGGPK SLPVPAPPGE MGTTPSAPPQ RNRRKSVHRV LAELDDESEP
PENPPPVLME PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP
QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT
