TCF19_MACMU
ID TCF19_MACMU Reviewed; 345 AA.
AC Q5TM48;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Transcription factor 19;
DE Short=TCF-19;
GN Name=TCF19;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15269276; DOI=10.1093/molbev/msh216;
RA Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT "Rhesus macaque class I duplicon structures, organization, and evolution
RT within the alpha block of the major histocompatibility complex.";
RL Mol. Biol. Evol. 21:2079-2091(2004).
CC -!- FUNCTION: Potential trans-activating factor that could play an
CC important role in the transcription of genes required for the later
CC stages of cell cycle progression. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AB128049; BAD69746.1; -; Genomic_DNA.
DR RefSeq; NP_001108423.1; NM_001114951.1.
DR RefSeq; XP_014991391.1; XM_015135905.1.
DR AlphaFoldDB; Q5TM48; -.
DR SMR; Q5TM48; -.
DR STRING; 9544.ENSMMUP00000020588; -.
DR PRIDE; Q5TM48; -.
DR GeneID; 714141; -.
DR KEGG; mcc:714141; -.
DR CTD; 6941; -.
DR eggNOG; ENOG502RHCY; Eukaryota.
DR HOGENOM; CLU_041089_0_0_1; -.
DR InParanoid; Q5TM48; -.
DR OrthoDB; 1106192at2759; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd00060; FHA; 1.
DR CDD; cd15609; PHD_TCF19; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR042803; TCF19.
DR InterPro; IPR039095; TCF19_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15464; PTHR15464; 2.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..345
FT /note="Transcription factor 19"
FT /id="PRO_0000232912"
FT DOMAIN 31..88
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT ZN_FING 293..342
FT /note="PHD-type"
FT REGION 138..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..215
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 37073 MW; B01C902B4F6FBE11 CRC64;
MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP GLISGIHAEL
HAEPRGDDWR VSLEDHSLQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYFM
FQQVRVKPQD FAAITIPRSR GETRAGAGFR PMLPSQGAPQ RPLSTLSPAP KATLILNSIG
SLSKLRPQPL TFSPSWGGPR SLPVPAPPGE VGNAPSAPPP RNRRKSVHRV LAELDDDSQP
SESPPPVLME PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP
QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT