TCF19_MOUSE
ID TCF19_MOUSE Reviewed; 263 AA.
AC Q99KJ5; Q8BPA3; Q9CT93;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Transcription factor 19-like protein;
DE Short=TCF-19;
DE AltName: Full=SC1 protein homolog;
GN Name=Tcf19; Synonyms=Sc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- MISCELLANEOUS: This sequence is very similar to other orthologs but it
CC lacks the PHD-type zinc finger domain which may be important for the
CC trans-activation function.
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DR EMBL; AK077414; BAC36789.1; -; mRNA.
DR EMBL; AK088479; BAC40380.1; -; mRNA.
DR EMBL; AK004231; BAB23229.1; -; mRNA.
DR EMBL; BC004617; AAH04617.1; -; mRNA.
DR CCDS; CCDS50089.1; -.
DR PIR; B61188; B61188.
DR RefSeq; NP_001157235.1; NM_001163763.1.
DR RefSeq; NP_001157236.1; NM_001163764.1.
DR RefSeq; NP_079950.2; NM_025674.2.
DR AlphaFoldDB; Q99KJ5; -.
DR SMR; Q99KJ5; -.
DR BioGRID; 223128; 3.
DR STRING; 10090.ENSMUSP00000125167; -.
DR PhosphoSitePlus; Q99KJ5; -.
DR PaxDb; Q99KJ5; -.
DR PRIDE; Q99KJ5; -.
DR ProteomicsDB; 254679; -.
DR DNASU; 106795; -.
DR GeneID; 106795; -.
DR KEGG; mmu:106795; -.
DR CTD; 6941; -.
DR MGI; MGI:103180; Tcf19.
DR eggNOG; ENOG502RHCY; Eukaryota.
DR InParanoid; Q99KJ5; -.
DR OrthoDB; 1106192at2759; -.
DR BioGRID-ORCS; 106795; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Tcf19; mouse.
DR PRO; PR:Q99KJ5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q99KJ5; protein.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IDA:MGI.
DR GO; GO:0044342; P:type B pancreatic cell proliferation; IMP:MGI.
DR CDD; cd00060; FHA; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR042803; TCF19.
DR PANTHER; PTHR15464; PTHR15464; 1.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..263
FT /note="Transcription factor 19-like protein"
FT /id="PRO_0000059330"
FT DOMAIN 31..88
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT REGION 140..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 78
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y242"
FT CONFLICT 32
FT /note="G -> R (in Ref. 1; BAC36789)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="Q -> E (in Ref. 1; BAB23229)"
FT /evidence="ECO:0000305"
FT CONFLICT 252
FT /note="R -> W (in Ref. 1; BAC36789)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 263 AA; 28068 MW; F210FECDD614E62A CRC64;
MLPCFQLLRI GGGRGGDLYT FHPPSKSGCT YGLGCRADLC DVALRPQQEP GLISGVHAEL
HAELQGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPQGQA GTSSSSEFYF
MFQQVRVKPQ DFAAITVPRS KGEAGGGFQP MLPPQGAPQR PLSTLSSAPK ATLILNSIGS
LSKLQAQPLT FSRGGGRPQG LAIPSQHGEA QVSPAPPTRN RRKSAHKVLA ELDDEVSPGP
LSVLTEPRKR LRVEKAALIA SGE
