TCF19_PANTR
ID TCF19_PANTR Reviewed; 345 AA.
AC Q7YR48; Q1XHV3; Q1XHV5;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Transcription factor 19;
DE Short=TCF-19;
DE AltName: Full=Transcription factor SC1;
GN Name=TCF19; Synonyms=SC1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12799463; DOI=10.1073/pnas.1230533100;
RA Anzai T., Shiina T., Kimura N., Yanagiya K., Kohara S., Shigenari A.,
RA Yamagata T., Kulski J.K., Naruse T.K., Fujimori Y., Fukuzumi Y.,
RA Yamazaki M., Tashiro H., Iwamoto C., Umehara Y., Imanishi T., Meyer A.,
RA Ikeo K., Gojobori T., Bahram S., Inoko H.;
RT "Comparative sequencing of human and chimpanzee MHC class I regions unveils
RT insertions/deletions as the major path to genomic divergence.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7708-7713(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16702430; DOI=10.1534/genetics.106.057034;
RA Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M.,
RA Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K.,
RA Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.,
RA Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T.,
RA Inoko H., Bahram S.;
RT "Rapid evolution of major histocompatibility complex class I genes in
RT primates generates new disease alleles in humans via hitchhiking
RT diversity.";
RL Genetics 173:1555-1570(2006).
CC -!- FUNCTION: Potential trans-activating factor that could play an
CC important role in the transcription of genes required for the later
CC stages of cell cycle progression. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; BA000041; BAC78166.1; -; Genomic_DNA.
DR EMBL; AB210197; BAE92815.1; -; Genomic_DNA.
DR EMBL; AB210198; BAE92817.1; -; Genomic_DNA.
DR RefSeq; NP_001129081.1; NM_001135609.1.
DR RefSeq; XP_009449065.1; XM_009450790.2.
DR RefSeq; XP_009449066.1; XM_009450791.2.
DR AlphaFoldDB; Q7YR48; -.
DR SMR; Q7YR48; -.
DR STRING; 9598.ENSPTRP00000043439; -.
DR PaxDb; Q7YR48; -.
DR Ensembl; ENSPTRT00000045450; ENSPTRP00000043439; ENSPTRG00000017952.
DR GeneID; 100190896; -.
DR KEGG; ptr:100190896; -.
DR CTD; 6941; -.
DR VGNC; VGNC:12712; TCF19.
DR eggNOG; ENOG502RHCY; Eukaryota.
DR GeneTree; ENSGT00390000015391; -.
DR HOGENOM; CLU_041089_0_0_1; -.
DR InParanoid; Q7YR48; -.
DR OMA; SGAGCTY; -.
DR OrthoDB; 1106192at2759; -.
DR TreeFam; TF334697; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000017952; Expressed in fibroblast and 16 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd00060; FHA; 1.
DR CDD; cd15609; PHD_TCF19; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR042803; TCF19.
DR InterPro; IPR039095; TCF19_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15464; PTHR15464; 2.
DR Pfam; PF00498; FHA; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..345
FT /note="Transcription factor 19"
FT /id="PRO_0000059328"
FT DOMAIN 31..88
FT /note="FHA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT ZN_FING 296..339
FT /note="PHD-type"
FT REGION 147..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..214
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 78
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y242"
SQ SEQUENCE 345 AA; 37144 MW; 45D666461FAFB9F8 CRC64;
MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP GLISGIHAEL
HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYFM
FQQVRVKPQD FAAITIPRSR GEARVGAGFR PMLPSQGAPQ RPLSTLSPAP KATLILNSIG
SLSKLRPQPL TFSPSWGGPK SLPVPAPPGE VGTTPSAPPQ RNRRKSVHRV LAELDDESEP
PENPPPVLME RRKKLRVDKA PLTPTGNRRG RPRKYPVSAP VAPPAVGGGE PCAAPCCCLP
QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT
