ID   TCF19_PIG               Reviewed;         346 AA.
AC   Q9TSV4; O19083;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Transcription factor 19;
DE            Short=TCF-19;
DE   AltName: Full=Transcription factor SC1;
GN   Name=TCF19; Synonyms=SC1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Large white; TISSUE=Fibroblast;
RX   PubMed=11169259; DOI=10.1034/j.1399-0039.2001.057001055.x;
RA   Chardon P., Rogel-Gaillard C., Cattolico L., Duprat S., Vaiman M.,
RA   Renard C.;
RT   "Sequence of the swine major histocompatibility complex region containing
RT   all non-classical class I genes.";
RL   Tissue Antigens 57:55-65(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 138-218.
RC   TISSUE=Peripheral blood;
RX   PubMed=9510374; DOI=10.1111/j.1399-0039.1998.tb02963.x;
RA   Velten F., Rogel-Gaillard C., Renard C., Vaiman M., Chardon P.;
RT   "A first map of the porcine major histocompatibility complex class I
RT   region.";
RL   Tissue Antigens 51:183-194(1998).
CC   -!- FUNCTION: Potential trans-activating factor that could play an
CC       important role in the transcription of genes required for the later
CC       stages of cell cycle progression. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AJ251914; CAB63863.1; -; Genomic_DNA.
DR   EMBL; Z97401; CAB10689.1; -; Genomic_DNA.
DR   RefSeq; NP_001161063.1; NM_001167591.1.
DR   RefSeq; XP_005665811.1; XM_005665754.2.
DR   AlphaFoldDB; Q9TSV4; -.
DR   SMR; Q9TSV4; -.
DR   STRING; 9823.ENSSSCP00000030891; -.
DR   PaxDb; Q9TSV4; -.
DR   PRIDE; Q9TSV4; -.
DR   Ensembl; ENSSSCT00070048510; ENSSSCP00070040962; ENSSSCG00070024292.
DR   GeneID; 100152381; -.
DR   KEGG; ssc:100152381; -.
DR   CTD; 6941; -.
DR   eggNOG; ENOG502RHCY; Eukaryota.
DR   HOGENOM; CLU_041089_0_0_1; -.
DR   InParanoid; Q9TSV4; -.
DR   OMA; SGAGCTY; -.
DR   OrthoDB; 1106192at2759; -.
DR   TreeFam; TF334697; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 7.
DR   Genevisible; Q9TSV4; SS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   CDD; cd00060; FHA; 1.
DR   CDD; cd15609; PHD_TCF19; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR042803; TCF19.
DR   InterPro; IPR039095; TCF19_PHD.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR15464; PTHR15464; 2.
DR   Pfam; PF00498; FHA; 1.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00249; PHD; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50006; FHA_DOMAIN; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..346
FT                   /note="Transcription factor 19"
FT                   /id="PRO_0000059329"
FT   DOMAIN          31..88
FT                   /note="FHA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00086"
FT   ZN_FING         297..340
FT                   /note="PHD-type"
FT   REGION          136..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..243
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         78
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y242"
SQ   SEQUENCE   346 AA;  37539 MW;  DEAFECB18BFE5964 CRC64;
     MLPCFQLLRI GGGRGVDLYT FHPPSGAGCT YRLGCRADLC DVALRPQQEP GFISEVHAEL
     HAERRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYMF
     QQVRVKPQDF AAITIPRSRG EEGETRAGFR PMLPSQGAPQ RPLSTLSPTP KATLILNSIG
     SLSKLHLQPL TFSRSGSGPQ NPPVSTTPGE VRTTPSAPPP RNRRKSAHRV LAELDDEREA
     PESLPPVLIE PRKKLLRVEK TPPTPSGNRR GRPRKHPVSI PRAPPAAGGG EPCAAPCCCL
     PQEETVAWVQ CDGCDTWFHV ACVGCSIQAA KEADFRCPGC RVGIQS