TCF21_DANRE
ID TCF21_DANRE Reviewed; 176 AA.
AC Q32PV5;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Transcription factor 21 {ECO:0000312|EMBL:AAI07969.1};
DE Short=TCF-21;
DE AltName: Full=Capsulin {ECO:0000312|EMBL:ABU95406.1};
DE AltName: Full=Epicardin {ECO:0000303|PubMed:18206866};
DE AltName: Full=MyoRa2 {ECO:0000303|PubMed:19449054};
GN Name=tcf21 {ECO:0000303|PubMed:18206866,
GN ECO:0000312|ZFIN:ZDB-GENE-051113-88};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:ABU95406.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Chang M.-Y., Chen Y.-H.;
RT "Molecular structure of zebrafish capsulin.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:ABU95406.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart {ECO:0000312|EMBL:AAI07969.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=18206866; DOI=10.1016/j.ydbio.2007.10.007;
RA Serluca F.C.;
RT "Development of the proepicardial organ in the zebrafish.";
RL Dev. Biol. 315:18-27(2008).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=18338789; DOI=10.1002/jez.b.21215;
RA Knight R.D., Mebus K., Roehl H.H.;
RT "Mandibular arch muscle identity is regulated by a conserved molecular
RT process during vertebrate development.";
RL J. Exp. Zool. B Mol. Dev. Evol. 310:355-369(2008).
RN [5] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=19449054; DOI=10.1007/s00239-009-9232-7;
RA Wang Y., Chen K., Yao Q., Zheng X., Yang Z.;
RT "Phylogenetic analysis of zebrafish basic helix-loop-helix transcription
RT factors.";
RL J. Mol. Evol. 68:629-640(2009).
CC -!- FUNCTION: Involved in epithelial-mesenchymal interactions in kidney and
CC lung morphogenesis that include epithelial differentiation and
CC branching morphogenesis. {ECO:0000250|UniProtKB:O43680}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250|UniProtKB:O43680}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43680,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in the cranial paraxial mesoderm from 20
CC hpf and subsequently becomes restricted to the pharyngeal mesoderm that
CC will form the muscle. Expression in the proepicardial organ is first
CC seen at 40hpf in a cluster of cells between the myocardium and yolk.
CC Also expressed in the developing arches. Expression begins to surround
CC the heart by day 3 of development, and by 96 hpf, expression is
CC restricted to the outer epicardial layer surrounding the myocardium.
CC {ECO:0000269|PubMed:18206866, ECO:0000269|PubMed:18338789}.
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DR EMBL; EF632300; ABU95406.1; -; mRNA.
DR EMBL; BC107968; AAI07969.1; -; mRNA.
DR RefSeq; NP_001032770.1; NM_001037681.1.
DR AlphaFoldDB; Q32PV5; -.
DR SMR; Q32PV5; -.
DR STRING; 7955.ENSDARP00000053538; -.
DR PaxDb; Q32PV5; -.
DR GeneID; 558148; -.
DR KEGG; dre:558148; -.
DR CTD; 6943; -.
DR ZFIN; ZDB-GENE-051113-88; tcf21.
DR eggNOG; KOG4029; Eukaryota.
DR InParanoid; Q32PV5; -.
DR OrthoDB; 1374128at2759; -.
DR PhylomeDB; Q32PV5; -.
DR PRO; PR:Q32PV5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; ISS:UniProtKB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060840; P:artery development; IGI:ZFIN.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0014707; P:branchiomeric skeletal muscle development; IMP:ZFIN.
DR GO; GO:0060435; P:bronchiole development; ISS:UniProtKB.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0060539; P:diaphragm development; ISS:UniProtKB.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0048732; P:gland development; ISS:UniProtKB.
DR GO; GO:0032835; P:glomerulus development; ISS:UniProtKB.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0048286; P:lung alveolus development; ISS:UniProtKB.
DR GO; GO:0060425; P:lung morphogenesis; ISS:UniProtKB.
DR GO; GO:0060426; P:lung vasculature development; ISS:UniProtKB.
DR GO; GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
DR GO; GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
DR GO; GO:0001763; P:morphogenesis of a branching structure; ISS:UniProtKB.
DR GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048608; P:reproductive structure development; ISS:UniProtKB.
DR GO; GO:0060541; P:respiratory system development; ISS:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; ISS:UniProtKB.
DR GO; GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB.
DR GO; GO:0007530; P:sex determination; ISS:UniProtKB.
DR GO; GO:0007519; P:skeletal muscle tissue development; IMP:ZFIN.
DR GO; GO:0048536; P:spleen development; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR GO; GO:0001944; P:vasculature development; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Differentiation; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..176
FT /note="Transcription factor 21"
FT /id="PRO_0000386430"
FT DOMAIN 76..128
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 176 AA; 19346 MW; AD05C77D86290C55 CRC64;
MSTGSISDVD EFHESELLDG LPKFGSGKDP GTSNESTEDS SNCEGASVSE CTGKRRKSAN
MRRSAPNGVA QEGKQVQRNA ANARERARMR VLSKAFSRLK TTLPWVPPDT KLSKLDTLRL
ASSYIAHLRQ ILANDKYENG YIHPVNLTWP FMVAGKPENE LKEMLNSTRL CGTTAS
