TCF21_XENLA
ID TCF21_XENLA Reviewed; 179 AA.
AC Q6GNB7;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Transcription factor 21 {ECO:0000312|EMBL:AAT74527.1};
DE Short=TCF-21;
DE AltName: Full=Capsulin {ECO:0000303|Ref.1};
DE AltName: Full=Epicardin {ECO:0000303|Ref.1};
DE AltName: Full=Podocyte-expressed 1 {ECO:0000303|PubMed:15744669};
DE Short=Pod 1 {ECO:0000303|PubMed:15744669};
DE Short=Pod-1 {ECO:0000303|PubMed:15744669};
GN Name=tcf21; Synonyms=pod1 {ECO:0000303|PubMed:15744669};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000312|EMBL:AAT74527.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney {ECO:0000312|EMBL:AAT74527.1};
RA Eid S.R., Braendli A.W.;
RT "Essential function of the basic helix-loop-helix transcription factor
RT Tcf21 (capsulin/epicardin/Pod1) for Xenopus pronephric kidney
RT organogenesis.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAT74527.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000312|EMBL:AAH73597.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15744669; DOI=10.1387/ijdb.051982ss;
RA Simrick S., Masse K., Jones E.A.;
RT "Developmental expression of Pod 1 in Xenopus laevis.";
RL Int. J. Dev. Biol. 49:59-63(2005).
CC -!- FUNCTION: Involved in epithelial-mesenchymal interactions in kidney and
CC lung morphogenesis that include epithelial differentiation and
CC branching morphogenesis. {ECO:0000250|UniProtKB:O43680}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250|UniProtKB:O43680}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43680,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: At the start of neurulation (stage 13), expressed
CC in the pronephros. At tailbud stage (stage 25-28), expression is high
CC in the anterior-most branchial arch and pronephric glomus. At stage 40,
CC staining persists in the glomus and in the epicardium region of the
CC heart, and at stage 42, expression is higher in the glomus than in the
CC kidney tubule or duct. In adults, expression is highest in the rectum
CC and the spleen, with significant expression in the duodenum, heart,
CC kidney, lungs, pancreas, skin, liver and muscle.
CC {ECO:0000269|PubMed:15744669}.
CC -!- DEVELOPMENTAL STAGE: Expression begins at the start of neurulation
CC (stage 13), followed by a gradual increase in expression from stages
CC 16.5 to 26.5, after which expression levels are maintained through to
CC stage 35. {ECO:0000269|PubMed:15744669}.
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DR EMBL; AY660871; AAT74527.1; -; mRNA.
DR EMBL; BC073597; AAH73597.1; -; mRNA.
DR RefSeq; NP_001085957.1; NM_001092488.1.
DR AlphaFoldDB; Q6GNB7; -.
DR SMR; Q6GNB7; -.
DR DNASU; 444386; -.
DR GeneID; 444386; -.
DR KEGG; xla:444386; -.
DR CTD; 444386; -.
DR Xenbase; XB-GENE-484809; tcf21.L.
DR OMA; CEGPCAN; -.
DR OrthoDB; 1374128at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 444386; Expressed in spleen and 10 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; ISS:UniProtKB.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0014707; P:branchiomeric skeletal muscle development; ISS:UniProtKB.
DR GO; GO:0060435; P:bronchiole development; ISS:UniProtKB.
DR GO; GO:0060539; P:diaphragm development; ISS:UniProtKB.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0048732; P:gland development; ISS:UniProtKB.
DR GO; GO:0032835; P:glomerulus development; ISS:UniProtKB.
DR GO; GO:0072013; P:glomus development; IMP:UniProtKB.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0048286; P:lung alveolus development; ISS:UniProtKB.
DR GO; GO:0060425; P:lung morphogenesis; ISS:UniProtKB.
DR GO; GO:0060426; P:lung vasculature development; ISS:UniProtKB.
DR GO; GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
DR GO; GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
DR GO; GO:0001763; P:morphogenesis of a branching structure; ISS:UniProtKB.
DR GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048608; P:reproductive structure development; ISS:UniProtKB.
DR GO; GO:0060541; P:respiratory system development; ISS:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; ISS:UniProtKB.
DR GO; GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB.
DR GO; GO:0007530; P:sex determination; ISS:UniProtKB.
DR GO; GO:0048536; P:spleen development; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR GO; GO:0001944; P:vasculature development; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Differentiation; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..179
FT /note="Transcription factor 21"
FT /id="PRO_0000386431"
FT DOMAIN 79..131
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 20..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 19789 MW; 507AFB8B7777D62B CRC64;
MSTGSLSDVE DFQDMEMLEC DGIKLDPNKE FGISNDSNEE SSTCDNGSPK KGRGTSGKRR
KASSKKSPLG TINQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT
LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ENDLKEVVST SRLCGPTAS
