TCF21_XENTR
ID TCF21_XENTR Reviewed; 179 AA.
AC A8E5T6;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Transcription factor 21 {ECO:0000250|UniProtKB:Q6GNB7};
DE Short=TCF-21;
DE AltName: Full=Capsulin {ECO:0000250|UniProtKB:Q6GNB7};
DE AltName: Full=Epicardin {ECO:0000250|UniProtKB:Q6GNB7};
DE AltName: Full=Podocyte-expressed 1 {ECO:0000250|UniProtKB:Q6GNB7};
DE Short=Pod 1 {ECO:0000250|UniProtKB:Q6GNB7};
DE Short=Pod-1 {ECO:0000250|UniProtKB:Q6GNB7};
GN Name=tcf21; Synonyms=pod1 {ECO:0000250|UniProtKB:Q6GNB7};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAI53712.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000312|EMBL:AAI53712.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in epithelial-mesenchymal interactions in kidney and
CC lung morphogenesis that include epithelial differentiation and
CC branching morphogenesis. {ECO:0000250|UniProtKB:O43680}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250|UniProtKB:O43680}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43680,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; BC153711; AAI53712.1; -; mRNA.
DR RefSeq; NP_001103518.1; NM_001110048.1.
DR AlphaFoldDB; A8E5T6; -.
DR SMR; A8E5T6; -.
DR PaxDb; A8E5T6; -.
DR DNASU; 100126209; -.
DR Ensembl; ENSXETT00000000219; ENSXETP00000000219; ENSXETG00000000114.
DR GeneID; 100126209; -.
DR KEGG; xtr:100126209; -.
DR CTD; 6943; -.
DR Xenbase; XB-GENE-484805; tcf21.
DR eggNOG; KOG4029; Eukaryota.
DR HOGENOM; CLU_092663_0_0_1; -.
DR InParanoid; A8E5T6; -.
DR OMA; CEGPCAN; -.
DR OrthoDB; 1374128at2759; -.
DR PhylomeDB; A8E5T6; -.
DR TreeFam; TF350742; -.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000000114; Expressed in mesonephros and 8 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; ISS:UniProtKB.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
DR GO; GO:0014707; P:branchiomeric skeletal muscle development; ISS:UniProtKB.
DR GO; GO:0060435; P:bronchiole development; ISS:UniProtKB.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0060539; P:diaphragm development; ISS:UniProtKB.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
DR GO; GO:0030855; P:epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0048732; P:gland development; ISS:UniProtKB.
DR GO; GO:0032835; P:glomerulus development; ISS:UniProtKB.
DR GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR GO; GO:0048286; P:lung alveolus development; ISS:UniProtKB.
DR GO; GO:0060425; P:lung morphogenesis; ISS:UniProtKB.
DR GO; GO:0060426; P:lung vasculature development; ISS:UniProtKB.
DR GO; GO:0072277; P:metanephric glomerular capillary formation; ISS:UniProtKB.
DR GO; GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
DR GO; GO:0001763; P:morphogenesis of a branching structure; ISS:UniProtKB.
DR GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048608; P:reproductive structure development; ISS:UniProtKB.
DR GO; GO:0060541; P:respiratory system development; ISS:UniProtKB.
DR GO; GO:0060021; P:roof of mouth development; ISS:UniProtKB.
DR GO; GO:0060008; P:Sertoli cell differentiation; ISS:UniProtKB.
DR GO; GO:0007530; P:sex determination; ISS:UniProtKB.
DR GO; GO:0048536; P:spleen development; ISS:UniProtKB.
DR GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
DR GO; GO:0001944; P:vasculature development; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Differentiation; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..179
FT /note="Transcription factor 21"
FT /id="PRO_0000386432"
FT DOMAIN 79..131
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 23..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 19794 MW; E5E556FBE5E42211 CRC64;
MSTGSLSDVE DFQEVEMLEC DGIKLDPNKE FGISNDSNEE SSTCDNGSPK KGRGTSGKRR
KAPSKKSPLG NINQEGKQVQ RNAANARERA RMRVLSKAFS RLKTTLPWVP PDTKLSKLDT
LRLASSYIAH LRQILANDKY ENGYIHPVNL TWPFMVAGKP ENDLKEVVST SRLCGPTAS
