ID   TCF23_BOVIN             Reviewed;         214 AA.
AC   Q2T9Q7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Transcription factor 23;
DE            Short=TCF-23;
GN   Name=TCF23;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits E-box-mediated binding and transactivation of bHLH
CC       factors. Inhibitory effect is similar to that of ID proteins. Inhibits
CC       the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA
CC       binding activity. Seems to play a role in the inhibition of myogenesis
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms inactive heterodimeric complexes with TCF3.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- DOMAIN: Both the bHLH region and the C-terminal portion are essential
CC       for inhibitory function. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC111311; AAI11312.1; -; mRNA.
DR   RefSeq; NP_001033305.1; NM_001038216.2.
DR   AlphaFoldDB; Q2T9Q7; -.
DR   SMR; Q2T9Q7; -.
DR   STRING; 9913.ENSBTAP00000019716; -.
DR   PaxDb; Q2T9Q7; -.
DR   GeneID; 616841; -.
DR   KEGG; bta:616841; -.
DR   CTD; 150921; -.
DR   eggNOG; KOG4029; Eukaryota.
DR   InParanoid; Q2T9Q7; -.
DR   OrthoDB; 1462533at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Myogenesis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..214
FT                   /note="Transcription factor 23"
FT                   /id="PRO_0000315819"
FT   DOMAIN          76..128
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  23439 MW;  DB4C07E0F7C478BF CRC64;
     MSQREARGAR AMPGLGQSPA KATPRLLAGT ERKRSRLSRR GQDLWEESSW SNQRWSRTAP
     NPRGARARSL ARGRSEASPE NAARERSRVR TLRQAFLALQ ATLPAVPPDT KLSKLDVLVL
     ATSYIAHLTR TLGQEMPGPS WPPFLRGLRY LHPLKKWPMR SRLYAGGLGC SGLDSTTASN
     SGQRTKEAEA GPHVSGEPDA LLSTRQLSPA PSDK