ID   TCF24_HUMAN             Reviewed;         167 AA.
AC   Q7RTU0; H3BPR9;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 3.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Transcription factor 24;
DE            Short=TCF-24;
GN   Name=TCF24;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14516699; DOI=10.1016/s0925-4773(03)00130-8;
RA   McLellan A.S., Langlands K., Kealey T.;
RT   "Exhaustive identification of human class II basic helix-loop-helix
RT   proteins by virtual library screening.";
RL   Mech. Dev. 119:S285-S291(2002).
CC   -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q7RTU0; Q8TD91-2: MAGEC3; NbExp=3; IntAct=EBI-18239606, EBI-10694180;
CC       Q7RTU0; P15884-3: TCF4; NbExp=3; IntAct=EBI-18239606, EBI-13636688;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA00306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC110998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK000144; DAA00306.1; ALT_SEQ; Genomic_DNA.
DR   CCDS; CCDS59103.1; -.
DR   RefSeq; NP_001180431.1; NM_001193502.1.
DR   RefSeq; XP_016868429.1; XM_017012940.1.
DR   AlphaFoldDB; Q7RTU0; -.
DR   SMR; Q7RTU0; -.
DR   BioGRID; 934215; 4.
DR   IntAct; Q7RTU0; 3.
DR   STRING; 9606.ENSP00000455444; -.
DR   iPTMnet; Q7RTU0; -.
DR   PhosphoSitePlus; Q7RTU0; -.
DR   BioMuta; TCF24; -.
DR   DMDM; 408360247; -.
DR   MassIVE; Q7RTU0; -.
DR   PaxDb; Q7RTU0; -.
DR   PeptideAtlas; Q7RTU0; -.
DR   PRIDE; Q7RTU0; -.
DR   Antibodypedia; 77224; 3 antibodies from 1 providers.
DR   DNASU; 100129654; -.
DR   Ensembl; ENST00000563496.2; ENSP00000455444.1; ENSG00000261787.2.
DR   GeneID; 100129654; -.
DR   KEGG; hsa:100129654; -.
DR   MANE-Select; ENST00000563496.2; ENSP00000455444.1; NM_001193502.2; NP_001180431.1.
DR   UCSC; uc022avl.1; human.
DR   CTD; 100129654; -.
DR   DisGeNET; 100129654; -.
DR   GeneCards; TCF24; -.
DR   HGNC; HGNC:32275; TCF24.
DR   HPA; ENSG00000261787; Tissue enhanced (kidney, testis).
DR   neXtProt; NX_Q7RTU0; -.
DR   OpenTargets; ENSG00000261787; -.
DR   VEuPathDB; HostDB:ENSG00000261787; -.
DR   eggNOG; KOG4029; Eukaryota.
DR   GeneTree; ENSGT00940000162447; -.
DR   HOGENOM; CLU_101416_3_0_1; -.
DR   InParanoid; Q7RTU0; -.
DR   OMA; HDNTPTD; -.
DR   OrthoDB; 1462533at2759; -.
DR   PhylomeDB; Q7RTU0; -.
DR   TreeFam; TF350742; -.
DR   PathwayCommons; Q7RTU0; -.
DR   SignaLink; Q7RTU0; -.
DR   BioGRID-ORCS; 100129654; 18 hits in 1075 CRISPR screens.
DR   GenomeRNAi; 100129654; -.
DR   Pharos; Q7RTU0; Tdark.
DR   PRO; PR:Q7RTU0; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q7RTU0; protein.
DR   Bgee; ENSG00000261787; Expressed in right uterine tube and 44 other tissues.
DR   Genevisible; Q7RTU0; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..167
FT                   /note="Transcription factor 24"
FT                   /id="PRO_0000405315"
FT   DOMAIN          49..101
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   167 AA;  17516 MW;  B1637A24221E6A59 CRC64;
     MDRGRPAGSP LSASAEPAPL AAAIRDSRPG RTGPGPAGPG GGSRSGSGRP AAANAARERS
     RVQTLRHAFL ELQRTLPSVP PDTKLSKLDV LLLATTYIAH LTRSLQDDAE APADAGLGAL
     RGDGYLHPVK KWPMRSRLYI GATGQFLKHS VSGEKTNHDN TPTDSQP