TCF25_DICDI
ID TCF25_DICDI Reviewed; 740 AA.
AC Q8T2A4; Q554R8;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Transcription factor 25 homolog;
DE Short=TCF-25;
GN Name=tcf25; ORFNames=DDB_G0274217;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May act as a transcriptional repressor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TCF25 family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70001.1; -; Genomic_DNA.
DR RefSeq; XP_644255.1; XM_639163.1.
DR AlphaFoldDB; Q8T2A4; -.
DR STRING; 44689.DDB0302366; -.
DR PaxDb; Q8T2A4; -.
DR PRIDE; Q8T2A4; -.
DR EnsemblProtists; EAL70001; EAL70001; DDB_G0274217.
DR GeneID; 8619683; -.
DR KEGG; ddi:DDB_G0274217; -.
DR dictyBase; DDB_G0274217; lsrA.
DR eggNOG; KOG2422; Eukaryota.
DR HOGENOM; CLU_375281_0_0_1; -.
DR InParanoid; Q8T2A4; -.
DR OMA; WPPLTKN; -.
DR PhylomeDB; Q8T2A4; -.
DR PRO; PR:Q8T2A4; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0071944; C:cell periphery; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:1990112; C:RQC complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; ISS:dictyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:dictyBase.
DR GO; GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.
DR InterPro; IPR006994; TCF25/Rqc1.
DR PANTHER; PTHR22684; PTHR22684; 1.
DR Pfam; PF04910; Tcf25; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..740
FT /note="Transcription factor 25 homolog"
FT /id="PRO_0000363151"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 54..134
FT /evidence="ECO:0000255"
FT COILED 639..672
FT /evidence="ECO:0000255"
FT COMPBIAS 49..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 85635 MW; 0BD87973F5ECFB83 CRC64;
MSTKALKKKQ HINVQHVNSS SDEGSEKKVV VVVNSVKPKF SMLNLSDEDD DKSDQDENED
KKDSESEESE EEEEEEEIEK EKPQAKEQLS SKQQKQKQQQ QASKKKQAKK KQQQKKKQQQ
QEKDELELNE IEKSSPPIIL SEIEIKDKEF RELFKINTVN LNPDNELKKL FGCKSSDIKG
QKKKSVHHFK KKNYIFVQPK PEWPDVMGGF MVMEICNDDK VPSSPTNATT TTTTTTTTTN
TVSPKLKSQQ QSLDGINYFK IKWGQTYSNI QEEFYLALTT HDPMSLVEII RYHPYHIDSL
LQLGQVCLQT ADYSKAGDFV EMAVFAFENV FHHLFNPLNG NCRFEYRHDQ NKSCFLAIFR
FIQIIGRRAC HRTALELCKI LLTWDYSDPL YVRLIIDYYS IRSKQYRFLV DLFTKLKTIT
PTNQGDLSLL PNFCYSAALA MYHLEREKST TTTSTSTSTS SSKSSSVEES SDILLQKALI
SFPMVLQPLL EKLKTNFSIP KNGKIITLEN DPFFKDDPLE KRIDHLVTLF VERNYQCWQT
PEILDWLKSN VIIVLDKVAA KHPMVKQLSD SIKAEYETVN QEVFDHLVLS EYSDVINRLT
PDIIEAMHAE GFRDILPQRD PNQAPPQHLR RGGIGQGFQI HQRNQQQQRR VQQQLRQLQQ
QQQQNLQHQQ QQPLEPLLQE NPDYTGPANP VLNFLHSLLP WNDPSIQRER QLAATQGTQQ
PAPGFLDDYV DFSDEDENEN
