ID   TCHL1_BOVIN             Reviewed;         872 AA.
AC   A6QP92;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Trichohyalin-like protein 1;
GN   Name=TCHHL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI49209.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC149208; AAI49209.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001193524.1; NM_001206595.1.
DR   AlphaFoldDB; A6QP92; -.
DR   SMR; A6QP92; -.
DR   STRING; 9913.ENSBTAP00000021074; -.
DR   PaxDb; A6QP92; -.
DR   PRIDE; A6QP92; -.
DR   GeneID; 518825; -.
DR   KEGG; bta:518825; -.
DR   CTD; 126637; -.
DR   eggNOG; ENOG502RU01; Eukaryota.
DR   InParanoid; A6QP92; -.
DR   OrthoDB; 769793at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   CDD; cd00213; S-100; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR034325; S-100_dom.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   InterPro; IPR042937; TCHHL1.
DR   PANTHER; PTHR47612; PTHR47612; 1.
DR   Pfam; PF01023; S_100; 1.
DR   SMART; SM01394; S_100; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..872
FT                   /note="Trichohyalin-like protein 1"
FT                   /id="PRO_0000341542"
FT   DOMAIN          46..81
FT                   /note="EF-hand"
FT   REGION          117..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          774..813
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          830..872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..187
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..310
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        512..573
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..695
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        736..756
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        852..872
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   872 AA;  95773 MW;  951F3370B95E80E3 CRC64;
     MPQLLRDILC VIETFHKYAR EDAATLTCTE LKQLIQSEFE DIFQPCAIHA VERNLNLLNI
     DSNGAISFDE FVLAIFSFLN VCYLDTQSLL NSEPRQVSKP EGMPHDMGLQ VTNETDQWTE
     GTSQTQDKVV LPSGTASSTH LSLEERAVEH NRVDPQGHTT AHKLPVETSE HSDSKNQHLK
     GDEQSQKVDQ DVSATGDSRT QRETSKPMAG SEQISSHTKG EGQNKEILQK GDILARKQSG
     TETGGRFGEQ EGSLGILHSP LEETTQRPGG SSEDQEVAGE KGVKGHPKSQ EPSVQGKDEP
     SSEHVDLPKQ AAARKPSQTQ KSAAAKDESR TAETPEPPIQ EKEYETRDLS VQGENRNVSE
     TPMVRVERKG VRGPEVHQTV GQKQIEEKTQ PPALEEPTED KKYHELQESS KEKNAGEDSE
     THELNSEGGE QKDSESEGAI SPGEEARHAE EGTAEALVNS KNAPEAEGTP GTRERIWELT
     TLENQSGEKN KMTTKIHDKL VKEDDGYQGE GSEPVATQND ERSPETPNSL TAEDGDSNSE
     TSDLFVQGDS QSQTNPFRGS VQGSDSNNPE TQKHLALSEE KRVQEAAVLA VRGEDEQVTE
     EHAQEHEGQG SATTGRGPAV EPRGHSDTQV FIVRDENTKS LEPGIPGAPN AGITKQLSVR
     QLPTKKDSRK ELKDQSPSTK KEEDGALEAQ EDLVKSLDEN NAVSQKTCPA TLEEETESPQ
     QLAGEQSLST KEHDPSVSES GLEERMQRDQ ELCLVERGAE HSSPLYEALQ EKMLQQTNVT
     QGEHQNQAQT ASVASPEIRR NQSSASLTND SSDGLVFFID RQALQKYIRE FLPDEDPTGA
     QQISAPQALE DKQGRPQREE LEPQKEASAP KQ