TCHL1_MOUSE
ID TCHL1_MOUSE Reviewed; 638 AA.
AC Q9D3P1; F8VQ46;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Trichohyalin-like protein 1;
GN Name=Tchhl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR EMBL; AK017244; BAB30648.1; -; mRNA.
DR EMBL; AC123859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS17582.1; -.
DR RefSeq; NP_082038.2; NM_027762.3.
DR AlphaFoldDB; Q9D3P1; -.
DR SMR; Q9D3P1; -.
DR BioGRID; 214638; 2.
DR STRING; 10090.ENSMUSP00000029516; -.
DR iPTMnet; Q9D3P1; -.
DR PhosphoSitePlus; Q9D3P1; -.
DR PaxDb; Q9D3P1; -.
DR PRIDE; Q9D3P1; -.
DR ProteomicsDB; 263090; -.
DR Antibodypedia; 34081; 110 antibodies from 25 providers.
DR DNASU; 71325; -.
DR Ensembl; ENSMUST00000029516; ENSMUSP00000029516; ENSMUSG00000027908.
DR GeneID; 71325; -.
DR KEGG; mmu:71325; -.
DR UCSC; uc008qfi.1; mouse.
DR CTD; 126637; -.
DR MGI; MGI:1918575; Tchhl1.
DR VEuPathDB; HostDB:ENSMUSG00000027908; -.
DR eggNOG; ENOG502RU01; Eukaryota.
DR GeneTree; ENSGT00940000162966; -.
DR HOGENOM; CLU_017117_1_0_1; -.
DR InParanoid; Q9D3P1; -.
DR OMA; DYGRTSE; -.
DR OrthoDB; 769793at2759; -.
DR TreeFam; TF337503; -.
DR BioGRID-ORCS; 71325; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9D3P1; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9D3P1; protein.
DR Bgee; ENSMUSG00000027908; Expressed in lip and 24 other tissues.
DR Genevisible; Q9D3P1; MM.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR CDD; cd00213; S-100; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR042937; TCHHL1.
DR PANTHER; PTHR47612; PTHR47612; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..638
FT /note="Trichohyalin-like protein 1"
FT /id="PRO_0000341544"
FT DOMAIN 49..84
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 134..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 24
FT /note="G -> V (in Ref. 1; BAB30648)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="K -> Q (in Ref. 1; BAB30648)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 638 AA; 70707 MW; 120A135A9CFD1875 CRC64;
MPRLLRGVFC VVEIFHKYAI EDGGNQATLT RTELRQLLEG EIGDFLQPHV FHAVERKLNL
LNFDRDGTIS FEEFVLAIFS LLNPSYFDIS LLNSEPRLMS KSEKIDAVDL GAIGGNIQQV
VGVGPTQERL IFPSEMASSG QPSNEEGEVG DEPMVSPCED IKTHSLPRNV SEPNDPENQQ
PKEDAQEVAQ NVPATEYDGV QFKRNTVVEV PKQSTSPTQE IPRERSKPSR RLSDTKISDH
MIQRPTEDEE HTSTTQDPFL QKRDKATGSE NTDLSVVAAT RKSSQTQEIF EPMDDTKLSE
AQETGKDAGR IPPETNLEEP KADAKVAESH GLPAQEREHN TRDQSVQSRS RNVSETSSRG
EQEGEWKEHE RITLSPTADA ETQDEKCQEF PGSWRENDAK KDSAAKDPSS EEGNQNLPEI
KEDSVSGKEA RHSEEDTVYA FEINKNSPAA EETLETRERS QELAPLEKQS QRKKHRATRI
QDKPVRKEDH NEGEDSELSL TQSDEGFCEI PNSLAPEVGK SSSEIAEPHV PEDSQSQIDH
HGDAKQESHT NNPDPQKQGA PGESSREQEA VVLSIQEDGQ LPEGQEQSAR DGLHDGLSSR
TKGGPGAAVE PSEGEEVQEA TAGRENRKAL EAESLEAQ
