ID   TCHP_XENLA              Reviewed;         499 AA.
AC   A0AUT1; Q7ZYN5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Trichoplein keratin filament-binding protein;
DE            Short=Protein TCHP;
GN   Name=tchp {ECO:0000250|UniProtKB:Q9BT92};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI24855.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH42932.1}, and
RC   Fat body {ECO:0000312|EMBL:AAI24855.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a 'capping' or 'branching' protein for keratin
CC       filaments in the cell periphery. May regulate K8/K18 filament and
CC       desmosome organization mainly at the apical or peripheral regions of
CC       simple epithelial cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BT92}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCHP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH42932.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 426.; Evidence={ECO:0000305};
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DR   EMBL; BC042932; AAH42932.1; ALT_SEQ; mRNA.
DR   EMBL; BC124854; AAI24855.1; -; mRNA.
DR   RefSeq; NP_001082520.1; NM_001089051.1.
DR   AlphaFoldDB; A0AUT1; -.
DR   SMR; A0AUT1; -.
DR   DNASU; 398528; -.
DR   GeneID; 398528; -.
DR   KEGG; xla:398528; -.
DR   CTD; 398528; -.
DR   Xenbase; XB-GENE-963792; tchp.L.
DR   OMA; QNSHYFR; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 398528; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   InterPro; IPR043596; CFAP53/TCHP.
DR   InterPro; IPR026773; TCHP.
DR   InterPro; IPR043597; TPH_dom.
DR   PANTHER; PTHR31183; PTHR31183; 1.
DR   PANTHER; PTHR31183:SF2; PTHR31183:SF2; 1.
DR   Pfam; PF13868; TPH; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..499
FT                   /note="Trichoplein keratin filament-binding protein"
FT                   /id="PRO_0000292613"
FT   REGION          260..426
FT                   /note="Trichohyalin/plectin homology domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BT92"
FT   COILED          17..143
FT                   /evidence="ECO:0000255"
FT   COILED          169..304
FT                   /evidence="ECO:0000255"
FT   COILED          405..485
FT                   /evidence="ECO:0000255"
FT   CONFLICT        43
FT                   /note="K -> I (in Ref. 1; AAH42932)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   499 AA;  61197 MW;  CA7664BE4E2CA03E CRC64;
     MALPTLPSNW HSRSRVLEQQ IVRQREQEAR LRHQWDQTNQ YFKQSNVCSS KQAQWSSRQS
     YQKSMNAFHQ EKQKEEKKKT LEYRREQLRK LLQEERDLLE EELKELRCNK EHNVSDMRQR
     TEELKSAREE RQKQLAEELL YEQWKKNNVK LREVESSLFK KHVVDAWGEQ ITARNQEKEE
     EDMEKKRLEN EYELARREAI ERMKRDKEKR QQQEEELARV LKWQMEELKL KDLEAKKLKK
     EQEDLLRQQW EIEELEEERR KMEQCRKKTE LSHFLSRQYN AQMKRRAQQV QEELEMDKKI
     LSALISKEDE DQHLQSARRE QAIADVAWMK HVIEEQLHLE RQREAELDTL FREEAKQVWA
     KRETEWERER NARNRLMKEV LAGRQMQIQE RIERNQLAQA ESVMNRERLL RQLEEARQFT
     SREKKQEEEQ KTARRTELEA QIAEQLLKGK EAIVQQEEEE KEFKLAEDLE NDLLQQEAEI
     MTQRGYQKKT YSRPRTAWS