ID   TCIM_BOVIN              Reviewed;         106 AA.
AC   Q5E969; Q3ZBI1;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Transcriptional and immune response regulator;
GN   Name=TCIM; Synonyms=TC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to be involved in the regulation of cell growth an
CC       differentiation, may play different and opposite roles depending on the
CC       tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving
CC       antagonistic activity of CBY1. Enhances the proliferation of follicular
CC       dendritic cells. Plays a role in the mitogen-activated MAPK2/3
CC       signaling pathway, positively regulates G1-to-S-phase transition of the
CC       cell cycle. In endothelial cells, enhances key inflammatory mediators
CC       and inflammatory response through the modulation of NF-kappaB
CC       transcriptional regulatory activity. Involved in the regulation of heat
CC       shock response, seems to play a positive feedback with HSF1 to modulate
CC       heat-shock downstream gene expression (By similarity). Plays a role in
CC       the regulation of hematopoiesis even if the mechanisms are unknown (By
CC       similarity). In cancers such as thyroid or lung cancer, it has been
CC       described as promoter of cell proliferation, G1-to-S-phase transition
CC       and inhibitor of apoptosis. However, it negatively regulates self-
CC       renewal of liver cancer cells via suppresion of NOTCH2 signaling (By
CC       similarity). {ECO:0000250|UniProtKB:Q9D915,
CC       ECO:0000250|UniProtKB:Q9NR00}.
CC   -!- SUBUNIT: Monomer. Interacts with NOTCH2 (via ANK repeats), the
CC       interaction inhibits the nuclear translocation of NOTCH2 N2ICD.
CC       Interacts (C-terminus) with CBY1 (C-terminus), TCIM competes with
CC       CTNNB1 for the interaction with CBY1. {ECO:0000250|UniProtKB:Q9NR00}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NR00}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NR00}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q9NR00}. Nucleus {ECO:0000250|UniProtKB:Q9NR00}.
CC       Note=Localizes in nucleus speckles in presence of CBY1. Translocates to
CC       the nucleus upon cellular stress such as H(2)O(2).
CC       {ECO:0000250|UniProtKB:Q9NR00}.
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DR   EMBL; BT021051; AAX09068.1; -; mRNA.
DR   EMBL; BC103283; AAI03284.1; -; mRNA.
DR   RefSeq; NP_001030567.1; NM_001035490.2.
DR   AlphaFoldDB; Q5E969; -.
DR   SMR; Q5E969; -.
DR   STRING; 9913.ENSBTAP00000044556; -.
DR   PaxDb; Q5E969; -.
DR   Ensembl; ENSBTAT00000047341; ENSBTAP00000044556; ENSBTAG00000033304.
DR   GeneID; 617047; -.
DR   KEGG; bta:617047; -.
DR   CTD; 56892; -.
DR   VEuPathDB; HostDB:ENSBTAG00000033304; -.
DR   VGNC; VGNC:49157; TCIM.
DR   eggNOG; ENOG502S1N0; Eukaryota.
DR   GeneTree; ENSGT00390000003458; -.
DR   HOGENOM; CLU_172922_0_0_1; -.
DR   InParanoid; Q5E969; -.
DR   OMA; ILDTDQD; -.
DR   OrthoDB; 1548471at2759; -.
DR   TreeFam; TF338287; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000033304; Expressed in bone marrow and 101 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016607; C:nuclear speck; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005112; F:Notch binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0034605; P:cellular response to heat; ISS:UniProtKB.
DR   GO; GO:0002264; P:endothelial cell activation involved in immune response; ISS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISS:UniProtKB.
DR   GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISS:UniProtKB.
DR   GO; GO:0010739; P:positive regulation of protein kinase A signaling; IEA:Ensembl.
DR   GO; GO:1900020; P:positive regulation of protein kinase C activity; IEA:Ensembl.
DR   GO; GO:1902806; P:regulation of cell cycle G1/S phase transition; ISS:UniProtKB.
DR   GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; ISS:UniProtKB.
DR   GO; GO:1903706; P:regulation of hemopoiesis; IEA:Ensembl.
DR   InterPro; IPR020282; Avpi1/C8orf4_dom.
DR   InterPro; IPR039580; Tcim.
DR   PANTHER; PTHR32358; PTHR32358; 1.
DR   Pfam; PF15063; TC1; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..106
FT                   /note="Transcriptional and immune response regulator"
FT                   /id="PRO_0000089604"
SQ   SEQUENCE   106 AA;  12278 MW;  5BC75154D3EAB8CF CRC64;
     MKAKPSHPAF SMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENIDQEALQR LFRNSGDKKA
     EERAKIIFAI DQDLEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH