TCL1B_HUMAN
ID TCL1B_HUMAN Reviewed; 128 AA.
AC O95988; A6NEK7; Q6IAR7; Q9UBQ4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=T-cell leukemia/lymphoma protein 1B;
DE AltName: Full=Oncogene TCL-1B;
DE Short=Oncogene TCL1B;
DE AltName: Full=SYN-1;
DE AltName: Full=Syncytiotrophoblast-specific protein;
DE AltName: Full=TCL1/MTCP1-like protein 1;
GN Name=TCL1B; Synonyms=TCL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND VARIANT
RP ARG-93.
RC TISSUE=Placenta;
RX PubMed=10344735;
RA Sugimoto J., Hatakeyama T., Narducci M.G., Russo G., Isobe M.;
RT "Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next
RT to the TCL1 locus.";
RL Cancer Res. 59:2313-2317(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10077617; DOI=10.1073/pnas.96.6.2949;
RA Pekarsky Y., Hallas C., Isobe M., Russo G., Croce C.M.;
RT "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:2949-2951(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Jiang B., Mendelson C.R.;
RT "A syncytiotrophoblast-specific gene Syn-1 cloned from human
RT syncytiotrophoblast subtracted cDNA library.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-93.
RC TISSUE=Lymphoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION, AND INTERACTION WITH AKT1 AND AKT2.
RX PubMed=10983986; DOI=10.1016/s1097-2765(00)00039-3;
RA Laine J., Kuenstle G., Obata T., Sha M., Noguchi M.;
RT "The protooncogene TCL1 is an Akt kinase coactivator.";
RL Mol. Cell 6:395-407(2000).
RN [9]
RP LACK OF INTERACTION WITH AKT3.
RX PubMed=11707444; DOI=10.1074/jbc.m107069200;
RA Laine J., Kuenstle G., Obata T., Noguchi M.;
RT "Differential regulation of Akt kinase isoforms by the members of the TCL1
RT oncogene family.";
RL J. Biol. Chem. 277:3743-3751(2002).
CC -!- FUNCTION: Enhances the phosphorylation and activation of AKT1 and AKT2.
CC {ECO:0000269|PubMed:10983986}.
CC -!- SUBUNIT: Interacts with AKT1 and AKT2 (via PH domain). Does not
CC interact with AKT3. {ECO:0000269|PubMed:10983986}.
CC -!- INTERACTION:
CC O95988; O95429: BAG4; NbExp=3; IntAct=EBI-727338, EBI-2949658;
CC O95988; Q5VUJ9-2: EFCAB2; NbExp=3; IntAct=EBI-727338, EBI-13317131;
CC O95988; O76003: GLRX3; NbExp=5; IntAct=EBI-727338, EBI-374781;
CC O95988; O15116: LSM1; NbExp=3; IntAct=EBI-727338, EBI-347619;
CC O95988; Q9Y4Y9: LSM5; NbExp=3; IntAct=EBI-727338, EBI-373007;
CC O95988; Q9UK45: LSM7; NbExp=3; IntAct=EBI-727338, EBI-348372;
CC O95988; Q9P0L2: MARK1; NbExp=5; IntAct=EBI-727338, EBI-968587;
CC O95988; Q99687-3: MEIS3; NbExp=3; IntAct=EBI-727338, EBI-18582591;
CC O95988; Q13064: MKRN3; NbExp=6; IntAct=EBI-727338, EBI-2340269;
CC O95988; Q9HB20: PLEKHA3; NbExp=3; IntAct=EBI-727338, EBI-11079894;
CC O95988; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-727338, EBI-302345;
CC O95988; P62308: SNRPG; NbExp=3; IntAct=EBI-727338, EBI-624585;
CC O95988; Q9Y3S2: ZNF330; NbExp=6; IntAct=EBI-727338, EBI-373456;
CC -!- TISSUE SPECIFICITY: Expressed in a variety of tissues including
CC placenta and testis. {ECO:0000269|PubMed:10077617,
CC ECO:0000269|PubMed:10344735}.
CC -!- MISCELLANEOUS: Activated in chronic T-cell leukemias (T-CLL) carrying
CC rearrangements of the 14q32.1 region.
CC -!- SIMILARITY: Belongs to the TCL1 family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/TCL1BID354ch14q32.html";
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DR EMBL; AB018563; BAA76712.1; -; mRNA.
DR EMBL; AB025274; BAA82476.1; -; Genomic_DNA.
DR EMBL; AF110465; AAD16996.1; -; Genomic_DNA.
DR EMBL; AF110466; AAD16997.1; -; mRNA.
DR EMBL; AF137027; AAD30130.1; -; mRNA.
DR EMBL; CR457087; CAG33368.1; -; mRNA.
DR EMBL; AL133467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471061; EAW81619.1; -; Genomic_DNA.
DR EMBL; BC041616; AAH41616.1; -; mRNA.
DR EMBL; BC051000; AAH51000.1; -; mRNA.
DR CCDS; CCDS32151.1; -.
DR RefSeq; NP_004909.1; NM_004918.3.
DR AlphaFoldDB; O95988; -.
DR SMR; O95988; -.
DR BioGRID; 114983; 46.
DR IntAct; O95988; 35.
DR STRING; 9606.ENSP00000343223; -.
DR iPTMnet; O95988; -.
DR PhosphoSitePlus; O95988; -.
DR BioMuta; TCL1B; -.
DR MassIVE; O95988; -.
DR PaxDb; O95988; -.
DR PeptideAtlas; O95988; -.
DR PRIDE; O95988; -.
DR ProteomicsDB; 51164; -.
DR Antibodypedia; 27286; 62 antibodies from 21 providers.
DR DNASU; 9623; -.
DR Ensembl; ENST00000340722.8; ENSP00000343223.6; ENSG00000213231.13.
DR GeneID; 9623; -.
DR KEGG; hsa:9623; -.
DR MANE-Select; ENST00000340722.8; ENSP00000343223.6; NM_004918.4; NP_004909.1.
DR UCSC; uc001yez.3; human.
DR CTD; 9623; -.
DR DisGeNET; 9623; -.
DR GeneCards; TCL1B; -.
DR HGNC; HGNC:11649; TCL1B.
DR HPA; ENSG00000213231; Tissue enhanced (bone marrow, lymphoid tissue, testis).
DR MIM; 603769; gene.
DR neXtProt; NX_O95988; -.
DR OpenTargets; ENSG00000213231; -.
DR PharmGKB; PA36401; -.
DR VEuPathDB; HostDB:ENSG00000213231; -.
DR eggNOG; ENOG502TEDJ; Eukaryota.
DR GeneTree; ENSGT00390000006885; -.
DR HOGENOM; CLU_168379_0_1_1; -.
DR InParanoid; O95988; -.
DR OMA; SPSHREW; -.
DR OrthoDB; 1544538at2759; -.
DR PhylomeDB; O95988; -.
DR TreeFam; TF340217; -.
DR PathwayCommons; O95988; -.
DR SignaLink; O95988; -.
DR SIGNOR; O95988; -.
DR BioGRID-ORCS; 9623; 19 hits in 1063 CRISPR screens.
DR ChiTaRS; TCL1B; human.
DR GeneWiki; TCL1B; -.
DR GenomeRNAi; 9623; -.
DR Pharos; O95988; Tbio.
DR PRO; PR:O95988; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; O95988; protein.
DR Bgee; ENSG00000213231; Expressed in granulocyte and 35 other tissues.
DR ExpressionAtlas; O95988; baseline and differential.
DR Genevisible; O95988; HS.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IDA:UniProtKB.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IDA:UniProtKB.
DR Gene3D; 2.40.15.10; -; 1.
DR InterPro; IPR004832; TCL1_MTCP1.
DR InterPro; IPR036672; TCL1_MTCP1_sf.
DR PANTHER; PTHR14060; PTHR14060; 1.
DR Pfam; PF01840; TCL1_MTCP1; 1.
DR SUPFAM; SSF50904; SSF50904; 1.
PE 1: Evidence at protein level;
KW Chromosomal rearrangement; Proto-oncogene; Reference proteome.
FT CHAIN 1..128
FT /note="T-cell leukemia/lymphoma protein 1B"
FT /id="PRO_0000184490"
FT VARIANT 93
FT /note="G -> R (in dbSNP:rs1064017)"
FT /evidence="ECO:0000269|PubMed:10344735,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_020467"
SQ SEQUENCE 128 AA; 14846 MW; 6BA2CF3F40F78B4D CRC64;
MASEASVRLG VPPGRLWIQR PGIYEDEEGR TWVTVVVRFN PSRREWARAS QGSRYEPSIT
VHLWQMAVHT RELLSSGQMP FSQLPAVWQL YPGRKYRAAD SSFWEIADHG QIDSMEQLVL
TYQPERKD
