ID   TCL1_ARATH              Reviewed;          84 AA.
AC   D3GKW6;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=MYB-like transcription factor TCL1;
DE   AltName: Full=Protein TRICHOMELESS 1;
GN   Name=TCL1; OrderedLocusNames=At2g30432; ORFNames=T6B20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Can-0, cv. Columbia, cv. Landsberg erecta, cv. Oy-0, and
RC   cv. Wassilewskija;
RX   PubMed=19818620; DOI=10.1016/j.cub.2009.08.057;
RA   Hilscher J., Schlotterer C., Hauser M.T.;
RT   "A single amino acid replacement in ETC2 shapes trichome patterning in
RT   natural Arabidopsis populations.";
RL   Curr. Biol. 19:1747-1751(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16463100; DOI=10.1007/s11103-005-2564-9;
RA   Alexandrov N.N., Troukhan M.E., Brover V.V., Tatarinova T., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Features of Arabidopsis genes and genome discovered using full-length
RT   cDNAs.";
RL   Plant Mol. Biol. 60:69-85(2006).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17933793; DOI=10.1242/dev.009597;
RA   Wang S., Kwak S.H., Zeng Q., Ellis B.E., Chen X.Y., Schiefelbein J.,
RA   Chen J.G.;
RT   "TRICHOMELESS1 regulates trichome patterning by suppressing GLABRA1 in
RT   Arabidopsis.";
RL   Development 134:3873-3882(2007).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=20622149; DOI=10.1105/tpc.109.072579;
RA   Yu N., Cai W.J., Wang S., Shan C.M., Wang L.J., Chen X.Y.;
RT   "Temporal control of trichome distribution by microRNA156-targeted SPL
RT   genes in Arabidopsis thaliana.";
RL   Plant Cell 22:2322-2335(2010).
CC   -!- FUNCTION: MYB-type transcription factor involved in trichome cell
CC       specification. Acts as a negative regulator of trichome patterning and
CC       formation by direct binding to the cis-acting regulatory elements of
CC       GL1, thus suppressing the expression of GL1.
CC       {ECO:0000269|PubMed:17933793}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17933793}.
CC   -!- TISSUE SPECIFICITY: Expressed in inflorescences and trichomes of
CC       rosette and cauline leaves. {ECO:0000269|PubMed:20622149}.
CC   -!- DISRUPTION PHENOTYPE: Trichome formation on inflorescence stems and
CC       pedicels. {ECO:0000269|PubMed:17933793}.
CC   -!- MISCELLANEOUS: Plants over-expressing TCL1 does not have any trichomes
CC       on rosette leaves, inflorescence stems, cauline leaves or floral
CC       organs. {ECO:0000305|PubMed:17933793}.
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DR   EMBL; FJ972668; ADC36198.1; -; Genomic_DNA.
DR   EMBL; FJ972671; ADC36201.1; -; Genomic_DNA.
DR   EMBL; FJ972672; ADC36202.1; -; Genomic_DNA.
DR   EMBL; FJ972673; ADC36203.1; -; Genomic_DNA.
DR   EMBL; FJ972674; ADC36204.1; -; Genomic_DNA.
DR   EMBL; FJ972675; ADC36205.1; -; Genomic_DNA.
DR   EMBL; U93215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002685; AEC08388.1; -; Genomic_DNA.
DR   EMBL; DQ108777; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001031445.1; NM_001036368.3.
DR   AlphaFoldDB; D3GKW6; -.
DR   SMR; D3GKW6; -.
DR   BioGRID; 528882; 14.
DR   IntAct; D3GKW6; 14.
DR   STRING; 3702.AT2G30432.1; -.
DR   iPTMnet; D3GKW6; -.
DR   PaxDb; D3GKW6; -.
DR   PRIDE; D3GKW6; -.
DR   EnsemblPlants; AT2G30432.1; AT2G30432.1; AT2G30432.
DR   GeneID; 3768521; -.
DR   Gramene; AT2G30432.1; AT2G30432.1; AT2G30432.
DR   KEGG; ath:AT2G30432; -.
DR   Araport; AT2G30432; -.
DR   TAIR; locus:1009023162; AT2G30432.
DR   eggNOG; ENOG502S4DP; Eukaryota.
DR   HOGENOM; CLU_178021_1_0_1; -.
DR   InParanoid; D3GKW6; -.
DR   OMA; KQPKFTH; -.
DR   OrthoDB; 1531077at2759; -.
DR   PhylomeDB; D3GKW6; -.
DR   PRO; PR:D3GKW6; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; D3GKW6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0010154; P:fruit development; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   GO; GO:2000039; P:regulation of trichome morphogenesis; IMP:TAIR.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50090; MYB_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..84
FT                   /note="MYB-like transcription factor TCL1"
FT                   /id="PRO_0000423050"
FT   DOMAIN          36..73
FT                   /note="Myb-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
SQ   SEQUENCE   84 AA;  10494 MW;  51F44986D78F834B CRC64;
     MDNTNRLRRL HCHKQPKFTH SSQEVSSMKW EFINMTEQEE DLIFRMYRLV GDRWDLIARR
     VVGREAKEIE RYWIMRNCDY FSHK