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TCL2_ARATH
ID   TCL2_ARATH              Reviewed;         100 AA.
AC   B3H4X8;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=MYB-like transcription factor TCL2;
DE   AltName: Full=Protein CAPRICE-like MYB4;
DE   AltName: Full=Protein TRICHOMELESS 2;
GN   Name=TCL2; Synonyms=CPL4; OrderedLocusNames=At2g30424; ORFNames=T6B20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Columbia, cv. Gr-1, cv. Landsberg erecta, and cv. Oy-0;
RX   PubMed=19818620; DOI=10.1016/j.cub.2009.08.057;
RA   Hilscher J., Schlotterer C., Hauser M.T.;
RT   "A single amino acid replacement in ETC2 shapes trichome patterning in
RT   natural Arabidopsis populations.";
RL   Curr. Biol. 19:1747-1751(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   FUNCTION, INTERACTION WITH GL3, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=22168948; DOI=10.1186/1471-2229-11-176;
RA   Gan L., Xia K., Chen J.G., Wang S.;
RT   "Functional characterization of TRICHOMELESS2, a new single-repeat R3 MYB
RT   transcription factor in the regulation of trichome patterning in
RT   Arabidopsis.";
RL   BMC Plant Biol. 11:176-176(2011).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=22489163; DOI=10.3390/ijms13033478;
RA   Tominaga-Wada R., Nukumizu Y.;
RT   "Expression Analysis of an R3-Type MYB Transcription Factor CPC-LIKE MYB4
RT   (TRICHOMELESS2) and CPL4-Related Transcripts in Arabidopsis.";
RL   Int. J. Mol. Sci. 13:3478-3491(2012).
CC   -!- FUNCTION: MYB-type transcription factor involved in trichome cell
CC       specification. Acts as a negative regulator of trichome patterning and
CC       formation. May function by suppressing the expression of GL3.
CC       {ECO:0000269|PubMed:22168948}.
CC   -!- SUBUNIT: Interacts with GL3. {ECO:0000269|PubMed:22168948}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22168948}.
CC   -!- TISSUE SPECIFICITY: Expressed in cotyledons, petioles, rosette leaves,
CC       hydathodes, cauline leaves, stems, pedicels and flower buds.
CC       {ECO:0000269|PubMed:22168948, ECO:0000269|PubMed:22489163}.
CC   -!- MISCELLANEOUS: Plants over-expressing TCL2 does not have any trichomes
CC       on rosette leaves, inflorescence stems, cauline leaves or floral
CC       organs. {ECO:0000305|PubMed:22168948}.
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DR   EMBL; FJ972677; ADC36207.1; -; Genomic_DNA.
DR   EMBL; FJ972679; ADC36209.1; -; Genomic_DNA.
DR   EMBL; FJ972680; ADC36210.1; -; Genomic_DNA.
DR   EMBL; FJ972681; ADC36211.1; -; Genomic_DNA.
DR   EMBL; U93215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002685; AEC08386.1; -; Genomic_DNA.
DR   RefSeq; NP_001118417.1; NM_001124945.2.
DR   AlphaFoldDB; B3H4X8; -.
DR   SMR; B3H4X8; -.
DR   BioGRID; 926895; 7.
DR   IntAct; B3H4X8; 6.
DR   STRING; 3702.AT2G30424.1; -.
DR   PaxDb; B3H4X8; -.
DR   PRIDE; B3H4X8; -.
DR   EnsemblPlants; AT2G30424.1; AT2G30424.1; AT2G30424.
DR   GeneID; 6240858; -.
DR   Gramene; AT2G30424.1; AT2G30424.1; AT2G30424.
DR   KEGG; ath:AT2G30424; -.
DR   Araport; AT2G30424; -.
DR   TAIR; locus:4515102929; AT2G30424.
DR   HOGENOM; CLU_178021_1_0_1; -.
DR   InParanoid; B3H4X8; -.
DR   OMA; KDIERYW; -.
DR   OrthoDB; 1531077at2759; -.
DR   PhylomeDB; B3H4X8; -.
DR   PRO; PR:B3H4X8; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; B3H4X8; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:TAIR.
DR   GO; GO:1900033; P:negative regulation of trichome patterning; IMP:TAIR.
DR   GO; GO:0048629; P:trichome patterning; IMP:TAIR.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..100
FT                   /note="MYB-like transcription factor TCL2"
FT                   /id="PRO_0000423051"
FT   DOMAIN          37..74
FT                   /note="Myb-like"
SQ   SEQUENCE   100 AA;  12219 MW;  DD8B8F3A56D1BA84 CRC64;
     MDNTNRLRHL RSRKQSKFTL GDTAEVNSVK WEFINMTEQE EDLIFRMHRL VGDRWDLIAG
     RVVGREAKDI ERYWIMRNCD HCSHKRRRVH KFYRFSISPP
 
 
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