ID   TCL2_CAEEL              Reviewed;         435 AA.
AC   Q9N428;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=T-cell defective protein 2;
GN   Name=tcl-2; ORFNames=Y38C1AA.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=12679102; DOI=10.1016/s0012-1606(02)00128-8;
RA   Zhao X., Sawa H., Herman M.A.;
RT   "tcl-2 encodes a novel protein that acts synergistically with Wnt signaling
RT   pathways in C. elegans.";
RL   Dev. Biol. 256:276-289(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: May act synergistically with the Wnt pathways to control T-
CC       cell fate specification, gonad development, and P12 cell fate
CC       specification. Required for the distribution of pop-1 and tlp-1
CC       proteins. {ECO:0000269|PubMed:12679102}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12679102}. Cytoplasm
CC       {ECO:0000269|PubMed:12679102}. Note=Cytoplasmic in neurons and nuclear
CC       in T-cells.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in the cytoplasm of the pharynx
CC       muscle cells and several head neurons, probably the IL1s or IL2s,
CC       throughout development. Also expressed in some other unidentified
CC       neurons in the tail region. Weakly expressed in the nuclei of the T-
CC       cells and the T-cell daughters. Not expressed in gonads and in P12
CC       cell. {ECO:0000269|PubMed:12679102}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY145133; AAN52916.1; -; mRNA.
DR   EMBL; FO081257; CCD70248.1; -; Genomic_DNA.
DR   RefSeq; NP_499875.2; NM_067474.5.
DR   AlphaFoldDB; Q9N428; -.
DR   SMR; Q9N428; -.
DR   BioGRID; 41995; 1.
DR   DIP; DIP-26644N; -.
DR   IntAct; Q9N428; 1.
DR   STRING; 6239.Y38C1AA.4a; -.
DR   PaxDb; Q9N428; -.
DR   EnsemblMetazoa; Y38C1AA.4a.1; Y38C1AA.4a.1; WBGene00006561.
DR   GeneID; 176832; -.
DR   KEGG; cel:CELE_Y38C1AA.4; -.
DR   UCSC; Y38C1AA.4; c. elegans.
DR   CTD; 176832; -.
DR   WormBase; Y38C1AA.4a; CE31644; WBGene00006561; tcl-2.
DR   eggNOG; ENOG502TG4Y; Eukaryota.
DR   InParanoid; Q9N428; -.
DR   OMA; WLVISTG; -.
DR   OrthoDB; 1170426at2759; -.
DR   PRO; PR:Q9N428; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00006561; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q9N428; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0008356; P:asymmetric cell division; IMP:WormBase.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..435
FT                   /note="T-cell defective protein 2"
FT                   /id="PRO_0000072450"
FT   REGION          65..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          322..352
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        131..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  48289 MW;  2C4A74AB66DCDF50 CRC64;
     MFSPDTNSEF YDDFYTKYNT NMAPTTSTFN AQPRLSLDSG LGLTNDSFYS TDLNETHLMD
     ISAGNASTSF QSQPPPQLES SPPTKWARIR TPPNRKKKIS HEGPNQEALP PGFNLFSPPS
     RKKIKTAFSS PPPKSMKTPD SLRKSIRISS PSPFKVTFSK TPLKLSNNEN VTGIHIGRSG
     TYYNKQVTGS ASKRCLLPSK PDGFTFLGSP GNSDVLDFPL QTTFEGFGDL DTPAKINAAL
     EVNNDDSMDY YQYAGMIETS SSLATYTNST GPLVENHARN LKSVPISRTA SRNLMKISRK
     SVEEPVPEPQ AVHVEPVIEK PTKISAKKEK EQKKSAAKEA ALKEAKEKEM RIWKLAPFET
     PKKEVPLYSG RWLVISTGRT LAQQELFSDA KSFFKANPPP APRAPQAPEL ASGPRRIPTI
     QRVTLFKHRY RSPRD