TCMPA_STRMU
ID TCMPA_STRMU Reviewed; 271 AA.
AC Q8DUY4;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Putative two-component membrane permease complex subunit SMU_746c;
GN OrderedLocusNames=SMU_746c;
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159;
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
RN [2]
RP FUNCTION, SUBUNIT, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 700610 / UA159;
RX PubMed=24142257; DOI=10.1128/jb.00960-13;
RA Krol J.E., Biswas S., King C., Biswas I.;
RT "SMU.746-SMU.747, a putative membrane permease complex, is involved in
RT aciduricity, acidogenesis, and biofilm formation in Streptococcus mutans.";
RL J. Bacteriol. 196:129-139(2014).
CC -!- FUNCTION: Could be part of a two-component membrane permease system
CC responsible for amino acid transport under low pH. Involved in
CC acidogenesis, biofilm formation and low-pH survival.
CC {ECO:0000269|PubMed:24142257}.
CC -!- SUBUNIT: Interacts with SMU_747c. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: SMU_746c-SMU_747c deletion affects biofilm
CC formation in a medium- and pH-dependent manner. Mutants show a reduced
CC ability to grow in acidified medium, but they survive both short-term
CC or long-term acid stress. Mutants have lower glycolytic activity.
CC Deletion does not affect membrane proton permeability.
CC {ECO:0000269|PubMed:24142257}.
CC -!- SIMILARITY: Belongs to the UPF0703 family. {ECO:0000305}.
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DR EMBL; AE014133; AAN58470.1; -; Genomic_DNA.
DR RefSeq; NP_721164.1; NC_004350.2.
DR RefSeq; WP_002263632.1; NC_004350.2.
DR AlphaFoldDB; Q8DUY4; -.
DR SMR; Q8DUY4; -.
DR STRING; 210007.SMU_746c; -.
DR PRIDE; Q8DUY4; -.
DR EnsemblBacteria; AAN58470; AAN58470; SMU_746c.
DR GeneID; 66817807; -.
DR KEGG; smu:SMU_746c; -.
DR PATRIC; fig|210007.7.peg.660; -.
DR eggNOG; COG3689; Bacteria.
DR HOGENOM; CLU_070027_1_0_9; -.
DR OMA; YINMKYS; -.
DR PhylomeDB; Q8DUY4; -.
DR Proteomes; UP000002512; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015402; DUF1980.
DR PANTHER; PTHR40047; PTHR40047; 1.
DR Pfam; PF09323; DUF1980; 1.
DR TIGRFAMs; TIGR03943; TIGR03943; 1.
PE 1: Evidence at protein level;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..271
FT /note="Putative two-component membrane permease complex
FT subunit SMU_746c"
FT /id="PRO_0000426728"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 271 AA; 30839 MW; 52EB6D559B12B9AF CRC64;
MIRFLILAGY FELGMYLQLS GKLDRYINSH YSYLAYISMA LSFILALVQL TIWMKRLKMH
SHLSGKAAKF FSPIILAIPV FIGLLVPTVP LDSTTVSAKG YHFPLAAGST TSGTSSDGTR
VQYLKPDTSL YFTKSAYQKE MRATLKKYKG SGKLQITTQN YMEVMEIIYL FPDEFKNRQI
EYVGFIYNDP KDKNSQFLFR FGIIHCIADS GVYGLLTTGG QTHYQNNTWV TVSGKLAIEY
NQNLKQTLPV LHISQSSQTM QPKNPYVYRV F