ID   TCMPB_STRMU             Reviewed;         301 AA.
AC   Q8DUY3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Putative two-component membrane permease complex subunit SMU_747c;
GN   OrderedLocusNames=SMU_747c;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
RN   [2]
RP   FUNCTION, SUBUNIT, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=24142257; DOI=10.1128/jb.00960-13;
RA   Krol J.E., Biswas S., King C., Biswas I.;
RT   "SMU.746-SMU.747, a putative membrane permease complex, is involved in
RT   aciduricity, acidogenesis, and biofilm formation in Streptococcus mutans.";
RL   J. Bacteriol. 196:129-139(2014).
CC   -!- FUNCTION: Could be part of a two-component membrane permease system
CC       responsible for amino acid transport under low pH. Involved in
CC       acidogenesis, biofilm formation and low-pH survival.
CC       {ECO:0000269|PubMed:24142257}.
CC   -!- SUBUNIT: Interacts with SMU_746c. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: SMU_746c-SMU_747c deletion affects biofilm
CC       formation in a medium- and pH-dependent manner. Mutants show a reduced
CC       ability to grow in acidified medium, but they survive both short-term
CC       or long-term acid stress. Mutants have lower glycolytic activity.
CC       Deletion does not affect membrane proton permeability.
CC       {ECO:0000269|PubMed:24142257}.
CC   -!- SIMILARITY: Belongs to the UPF0718 family. {ECO:0000305}.
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DR   EMBL; AE014133; AAN58471.1; -; Genomic_DNA.
DR   RefSeq; NP_721165.1; NC_004350.2.
DR   RefSeq; WP_002263631.1; NC_004350.2.
DR   AlphaFoldDB; Q8DUY3; -.
DR   STRING; 210007.SMU_747c; -.
DR   DNASU; 1029471; -.
DR   EnsemblBacteria; AAN58471; AAN58471; SMU_747c.
DR   KEGG; smu:SMU_747c; -.
DR   PATRIC; fig|210007.7.peg.661; -.
DR   eggNOG; COG0701; Bacteria.
DR   HOGENOM; CLU_039914_2_0_9; -.
DR   OMA; IPMYICA; -.
DR   PhylomeDB; Q8DUY3; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005524; DUF318.
DR   Pfam; PF03773; ArsP_1; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..301
FT                   /note="Putative two-component membrane permease complex
FT                   subunit SMU_747c"
FT                   /id="PRO_0000426729"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   301 AA;  33274 MW;  E4C0A39AFA683F3E CRC64;
     MAIFNHLPSS VLQCLAIFLS IIIEALPFIL LGAILSGFIE VYLTPDIVQK YLPKNKIGRI
     LFGTFVGFIF PSCECGIVPI VNRFLEKKVP SYTAIPFLAT APIINPIVLF ATFSAFGNSW
     RFVFLRLFGA IIVAISLGIL LGFIVDEHII KESAKPCHFH DYSHKKAYQK IFYALAHAVD
     ELFDTGRYLI FGSFVAASMQ IYVPTRILTS IGHNPLTAIL IMMLLAFILS LCSEADAFIG
     TSLLATFGVA PVVAFLLIGP MVDIKNLMMM KNAFKTKFIL QFVGTSSLII IIYCLIVGVM
     Q