ID   TCMP_STRGA              Reviewed;         270 AA.
AC   P39887;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Tetracenomycin polyketide synthesis O-methyltransferase TcmP;
DE            EC=2.1.1.-;
GN   Name=tcmP;
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RX   PubMed=8509339; DOI=10.1128/jb.175.12.3876-3886.1993;
RA   Decker H., Motamedi H., Hutchinson C.R.;
RT   "Nucleotide sequences and heterologous expression of tcmG and tcmP,
RT   biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.";
RL   J. Bacteriol. 175:3876-3886(1993).
CC   -!- FUNCTION: O-methyltransferase that catalyzes the methylation of the C-9
CC       carboxy group of tetracenomycin E (TCM E) to yield TCM A2. Catalyzes as
CC       well the following side reactions: methylation of 8-O-methyl-TCM D3 to
CC       9-carboxymethyl-8-O-methyl-TCM D3; and of TCM B3 to 9-carboxymethyl-TCM
CC       B3.
CC   -!- PATHWAY: Antibiotic biosynthesis; tetracenomycin C biosynthesis.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA67510.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M80674; AAA67510.1; ALT_INIT; Genomic_DNA.
DR   PIR; S27688; C47127.
DR   RefSeq; WP_043504907.1; NZ_CP009438.1.
DR   AlphaFoldDB; P39887; -.
DR   SMR; P39887; -.
DR   STRING; 1907.SGLAU_26330; -.
DR   PRIDE; P39887; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; WGSVEWT; -.
DR   OrthoDB; 847145at2; -.
DR   BioCyc; MetaCyc:MON-18606; -.
DR   UniPathway; UPA00174; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016874; TcmP-like.
DR   Pfam; PF04072; LCM; 1.
DR   PIRSF; PIRSF028177; Polyketide_synth_Omtfrase_TcmP; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Methyltransferase; Transferase.
FT   CHAIN           1..270
FT                   /note="Tetracenomycin polyketide synthesis O-
FT                   methyltransferase TcmP"
FT                   /id="PRO_0000072458"
SQ   SEQUENCE   270 AA;  30886 MW;  53D14779B2265F83 CRC64;
     MGETIRLTGV HETLLATLQA RALDNRQPRP VLGDATAEEL LRRIDYDFSR IRTATKDMRI
     VTFRARKLDE WAGRFLAVHP DAVVLHLACG LDSRAFRMDV PDTVEWIDVD VPDVIELRSR
     LYPERDGYRM IGASVTTEDW LDTVPRNRPA LVVAEGLTPY LREADGEEML RRVIRHLPTG
     AVMFDAVLPW TLRFAKYSQL LRATGATFGW GIGNPRSLES RVPGLRFQEQ WSMLDSPFLA
     DARPVEKWVG AGMRSIPQLR FAHRLLRYTF