ID   TCMR_STRGA              Reviewed;         226 AA.
AC   P39885;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=HTH-type transcriptional regulator TcmR;
DE   AltName: Full=Tetracenomycin C transcriptional repressor;
GN   Name=tcmR;
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RX   PubMed=1592819; DOI=10.1128/jb.174.11.3651-3658.1992;
RA   Guilfoile P.G., Hutchinson C.R.;
RT   "Sequence and transcriptional analysis of the Streptomyces glaucescens
RT   tcmAR tetracenomycin C resistance and repressor gene loci.";
RL   J. Bacteriol. 174:3651-3658(1992).
RN   [2]
RP   FUNCTION.
RC   STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RX   PubMed=1592820; DOI=10.1128/jb.174.11.3659-3666.1992;
RA   Guilfoile P.G., Hutchinson C.R.;
RT   "The Streptomyces glaucescens TcmR protein represses transcription of the
RT   divergently oriented tcmR and tcmA genes by binding to an intergenic
RT   operator region.";
RL   J. Bacteriol. 174:3659-3666(1992).
CC   -!- FUNCTION: Represses transcription of the divergently oriented tcmR and
CC       tcmA (tetracenomycin C resistance and export) genes by binding to an
CC       intergenic operator region. This binding is inhibited by tetracenomycin
CC       C. {ECO:0000269|PubMed:1592820}.
CC   -!- PATHWAY: Antibiotic biosynthesis; tetracenomycin C biosynthesis.
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DR   EMBL; M80674; AAA67508.1; ALT_SEQ; Genomic_DNA.
DR   PIR; S27686; S27686.
DR   RefSeq; WP_052413891.1; NZ_CP009438.1.
DR   AlphaFoldDB; P39885; -.
DR   SMR; P39885; -.
DR   STRING; 1907.SGLAU_26320; -.
DR   PRIDE; P39885; -.
DR   eggNOG; COG1309; Bacteria.
DR   OMA; WTERYLA; -.
DR   OrthoDB; 1437290at2; -.
DR   UniPathway; UPA00174; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR041347; MftR_C.
DR   Pfam; PF17754; TetR_C_14; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..226
FT                   /note="HTH-type transcriptional regulator TcmR"
FT                   /id="PRO_0000070611"
FT   DOMAIN          26..86
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        49..68
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25377 MW;  389C426A9054060C CRC64;
     MDSAETDTPS TRSTPNGPGL RQRKLRRTRD QLIREALELF LAQGYEHTTV EQIAEAVEVH
     PRTFFRHFAS KEEVALTPIS AIDEAFLAAL EVRPAGENPL QAMSGAFRAV LGRVRDGELE
     GVDGALHMAM MRLVERTPGL LAEYLRRSEE MEGRLARIIA AREGVDLDDD FRPRFIVAVF
     KAVGRVVSRE WYLRADTDLE ALSVAFESAL DSLRPELFAD WRRPGA