ID   TCO2_PONAB              Reviewed;         427 AA.
AC   Q5REL7;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Transcobalamin-2;
DE            Short=TC-2;
DE   AltName: Full=Transcobalamin II;
DE            Short=TC II;
DE            Short=TCII;
DE   Flags: Precursor;
GN   Name=TCN2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Primary vitamin B12-binding and transport protein. Delivers
CC       cobalamin to cells. {ECO:0000250|UniProtKB:P20062}.
CC   -!- SUBUNIT: Interacts with CD320 (via LDL-receptor class A domains).
CC       {ECO:0000250|UniProtKB:P20062}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P20062}.
CC   -!- SIMILARITY: Belongs to the eukaryotic cobalamin transport proteins
CC       family. {ECO:0000305}.
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DR   EMBL; CR857507; CAH89790.1; -; mRNA.
DR   RefSeq; NP_001124823.1; NM_001131351.1.
DR   AlphaFoldDB; Q5REL7; -.
DR   SMR; Q5REL7; -.
DR   STRING; 9601.ENSPPYP00000013071; -.
DR   GeneID; 100171681; -.
DR   KEGG; pon:100171681; -.
DR   CTD; 6948; -.
DR   eggNOG; ENOG502QSED; Eukaryota.
DR   InParanoid; Q5REL7; -.
DR   OrthoDB; 1233171at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0031419; F:cobalamin binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0015889; P:cobalamin transport; ISS:UniProtKB.
DR   GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002157; Cbl-bd_prot.
DR   Pfam; PF01122; Cobalamin_bind; 1.
DR   PROSITE; PS00468; COBALAMIN_BINDING; 1.
PE   2: Evidence at transcript level;
KW   Cobalt; Cobalt transport; Disulfide bond; Ion transport; Metal-binding;
KW   Reference proteome; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..427
FT                   /note="Transcobalamin-2"
FT                   /id="PRO_0000005566"
FT   BINDING         104
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /evidence="ECO:0000250"
FT   BINDING         152..156
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /evidence="ECO:0000250"
FT   BINDING         190..194
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /evidence="ECO:0000250"
FT   BINDING         190
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /ligand_part="Co"
FT                   /ligand_part_id="ChEBI:CHEBI:27638"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
FT   BINDING         242
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /evidence="ECO:0000250"
FT   BINDING         245
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /evidence="ECO:0000250"
FT   BINDING         291
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /evidence="ECO:0000250"
FT   BINDING         395..397
FT                   /ligand="cob(II)alamin"
FT                   /ligand_id="ChEBI:CHEBI:16304"
FT                   /evidence="ECO:0000250"
FT   DISULFID        21..267
FT                   /evidence="ECO:0000250"
FT   DISULFID        116..309
FT                   /evidence="ECO:0000250"
FT   DISULFID        165..205
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   427 AA;  47391 MW;  273EF51BCCCFA6A4 CRC64;
     MRHLGALLFL LGVLGALAEI CEIPEVDSHL VEKLGQHLLP WMDRLSLEHL NPSIYVDLRL
     SSLQAGTKEE LYLHSLKLGY QQCLLGSAFS EDDGDCQGKP SMGQLALYLL ALRANCEFVR
     GHKGDKLVSQ LKRFLEDEKR AIGHDHKGHP HTSYYQYGLG ILALCLHQKR VHDSVVDKLL
     YALEPFHQGH HSVDTAAMAG LAFTCLKRSN FNPGRRQRIT MAVRTVREKI LKAQTPEGHF
     GNVYSTPLAL QFLMTSPMPG AELGTACLKA RVALFASLQD GAFQNALMIS QLLPVLNHKT
     YIDLIFPDCL APRVMLEPAA ETIPQAQEII SVTLQVLSLL PPYRQSISVL AGSTVEDVLK
     KAHELGGFTY ETQASLSGPY LISVMGKAAG EREFWQLLRD PNTPLLQGIA DYRPKDGETI
     ELRLVSW