TCP18_ARATH
ID TCP18_ARATH Reviewed; 433 AA.
AC A1YKT1; A0AQW3; Q9LII4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Transcription factor TCP18;
DE AltName: Full=Protein BRANCHED 1;
DE AltName: Full=Protein TEOSINTE BRANCHED 1-LIKE 1;
GN Name=TCP18; Synonyms=BRC1, TBL1; OrderedLocusNames=At3g18550;
GN ORFNames=K24M9.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, INDUCTION, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=17307924; DOI=10.1105/tpc.106.048934;
RA Aguilar-Martinez J.A., Poza-Carrion C., Cubas P.;
RT "Arabidopsis BRANCHED1 acts as an integrator of branching signals within
RT axillary buds.";
RL Plant Cell 19:458-472(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=17452340; DOI=10.1093/pcp/pcm044;
RA Finlayson S.A.;
RT "Arabidopsis TEOSINTE BRANCHED1-LIKE 1 regulates axillary bud outgrowth and
RT is homologous to monocot TEOSINTE BRANCHED1.";
RL Plant Cell Physiol. 48:667-677(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Transcription factor that prevents axillary bud outgrowth and
CC delays early axillary bud development. Indirectly required for the
CC auxin-induced control of apical dominance.
CC {ECO:0000269|PubMed:17307924, ECO:0000269|PubMed:17452340}.
CC -!- INTERACTION:
CC A1YKT1; F4JI72: At4g03250; NbExp=4; IntAct=EBI-15192731, EBI-15192535;
CC A1YKT1; F4K1A8: At5g26749; NbExp=3; IntAct=EBI-15192731, EBI-15191587;
CC A1YKT1; Q9FMC2: BZIP43; NbExp=3; IntAct=EBI-15192731, EBI-1237855;
CC A1YKT1; Q84MC7: PYL9; NbExp=3; IntAct=EBI-15192731, EBI-2349513;
CC A1YKT1; F4K5X6: RVE2; NbExp=3; IntAct=EBI-15192731, EBI-15194007;
CC A1YKT1; Q6X7J9: WOX4; NbExp=3; IntAct=EBI-15192731, EBI-4459694;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00701,
CC ECO:0000269|PubMed:17307924}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A1YKT1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1YKT1-2; Sequence=VSP_033117;
CC -!- TISSUE SPECIFICITY: Expressed in unelongated axillary buds, and, to a
CC lower extent, in axillary structures such as flowers and siliques.
CC {ECO:0000269|PubMed:17307924, ECO:0000269|PubMed:17452340}.
CC -!- DEVELOPMENTAL STAGE: Detected in axillary mersitems which appears in
CC the axils of leaves after flowering. During bud vegetative development,
CC down-regulated in the outer layers of the meristem, but accumulates
CC transiently in young leaf primordia. In buds bearing flowers,
CC restricted to the provascular tissue underlying the bud. Accumulates in
CC axillary buds, but disappears at the time of bud outgrowth.
CC {ECO:0000269|PubMed:17307924}.
CC -!- INDUCTION: Induced during environmentally induced bud dormancy
CC (planting density). Repressed transiently after shoot apical meristem
CC (SAM) decapitation (release from apical dominance).
CC {ECO:0000269|PubMed:17307924}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB02213.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AM408560; CAL64010.1; -; mRNA.
DR EMBL; EF062581; ABM05498.1; -; mRNA.
DR EMBL; AP001303; BAB02213.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE76115.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76116.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65598.1; -; Genomic_DNA.
DR RefSeq; NP_001118656.1; NM_001125184.1. [A1YKT1-2]
DR RefSeq; NP_001319582.1; NM_001338345.1. [A1YKT1-1]
DR RefSeq; NP_188485.2; NM_112741.3. [A1YKT1-1]
DR AlphaFoldDB; A1YKT1; -.
DR SMR; A1YKT1; -.
DR BioGRID; 6719; 73.
DR IntAct; A1YKT1; 70.
DR STRING; 3702.AT3G18550.1; -.
DR PaxDb; A1YKT1; -.
DR PRIDE; A1YKT1; -.
DR EnsemblPlants; AT3G18550.1; AT3G18550.1; AT3G18550. [A1YKT1-1]
DR EnsemblPlants; AT3G18550.2; AT3G18550.2; AT3G18550. [A1YKT1-2]
DR EnsemblPlants; AT3G18550.4; AT3G18550.4; AT3G18550. [A1YKT1-1]
DR GeneID; 821386; -.
DR Gramene; AT3G18550.1; AT3G18550.1; AT3G18550. [A1YKT1-1]
DR Gramene; AT3G18550.2; AT3G18550.2; AT3G18550. [A1YKT1-2]
DR Gramene; AT3G18550.4; AT3G18550.4; AT3G18550. [A1YKT1-1]
DR KEGG; ath:AT3G18550; -.
DR Araport; AT3G18550; -.
DR TAIR; locus:2086929; AT3G18550.
DR eggNOG; ENOG502QUQ6; Eukaryota.
DR InParanoid; A1YKT1; -.
DR OMA; PCQEETE; -.
DR PRO; PR:A1YKT1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; A1YKT1; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:2000032; P:regulation of secondary shoot formation; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0010223; P:secondary shoot formation; IMP:CACAO.
DR InterPro; IPR017888; CYC/TB1_R_domain.
DR InterPro; IPR017887; TF_TCP_subgr.
DR InterPro; IPR005333; Transcription_factor_TCP.
DR PANTHER; PTHR31072; PTHR31072; 1.
DR Pfam; PF03634; TCP; 1.
DR PROSITE; PS51370; R; 1.
DR PROSITE; PS51369; TCP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..433
FT /note="Transcription factor TCP18"
FT /id="PRO_0000330792"
FT DOMAIN 148..206
FT /note="TCP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00701"
FT DOMAIN 287..304
FT /note="R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00702"
FT REGION 130..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 226..229
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17307924"
FT /id="VSP_033117"
SQ SEQUENCE 433 AA; 49676 MW; E472DD229CAFBC1B CRC64;
MNNNIFSTTT TINDDYMLFP YNDHYSSQPL LPFSPSSSIN DILIHSTSNT SNNHLDHHHQ
FQQPSPFSHF EFAPDCALLT SFHPENNGHD DNQTIPNDNH HPSLHFPLNN TIVEQPTEPS
ETINLIEDSQ RISTSQDPKM KKAKKPSRTD RHSKIKTAKG TRDRRMRLSL DVAKELFGLQ
DMLGFDKASK TVEWLLTQAK PEIIKIATTL SHHGCFSSGD ESHIRPVLGS MDTSSDLCEL
ASMWTVDDRG SNTNTTETRG NKVDGRSMRG KRKRPEPRTP ILKKLSKEER AKARERAKGR
TMEKMMMKMK GRSQLVKVVE EDAHDHGEII KNNNRSQVNR SSFEMTHCED KIEELCKNDR
FAVCNEFIMN KKDHISNESY DLVNYKPNSS FPVINHHRSQ GAANSIEQHQ FTDLHYSFGA
KPRDLMHNYQ NMY
