ID   TCP1L_PANTR             Reviewed;         217 AA.
AC   Q68US1;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=T-complex protein 10A homolog 1;
DE            Short=T-complex protein 10A-1;
DE            Short=TCP10A-1;
DE   AltName: Full=TCP10-like;
GN   Name=TCP10L;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164055; DOI=10.1038/nature02564;
RA   Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A., Kuroki Y.,
RA   Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M., Taenzer S.,
RA   Galgoczy P., Platzer M., Scharfe M., Nordsiek G., Bloecker H., Hellmann I.,
RA   Khaitovich P., Paeaebo S., Reinhardt R., Zheng H.-J., Zhang X.-L.,
RA   Zhu G.-F., Wang B.-F., Fu G., Ren S.-X., Zhao G.-P., Chen Z., Lee Y.-S.,
RA   Cheong J.-E., Choi S.-H., Wu K.-M., Liu T.-T., Hsiao K.-J., Tsai S.-F.,
RA   Kim C.-G., Oota S., Kitano T., Kohara Y., Saitou N., Park H.-S.,
RA   Wang S.-Y., Yaspo M.-L., Sakaki Y.;
RT   "DNA sequence and comparative analysis of chimpanzee chromosome 22.";
RL   Nature 429:382-388(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation. Has in vitro
CC       transcription inhibition activity. {ECO:0000250|UniProtKB:Q8TDR4}.
CC   -!- SUBUNIT: Self-associates (via leucine zipper). Interacts (via leucine
CC       zipper) with ZIPK/DAPK3 (via leucine zipper). Interacts with MAD4.
CC       {ECO:0000250|UniProtKB:Q8TDR4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TDR4}.
CC   -!- SIMILARITY: Belongs to the TCP10 family. {ECO:0000305}.
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DR   EMBL; AL954209; CAH18590.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q68US1; -.
DR   SMR; Q68US1; -.
DR   STRING; 9598.ENSPTRP00000055314; -.
DR   InParanoid; Q68US1; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   InterPro; IPR026581; TCP10_fam.
DR   PANTHER; PTHR10331; PTHR10331; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..217
FT                   /note="T-complex protein 10A homolog 1"
FT                   /id="PRO_0000072463"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..96
FT                   /note="Leucine-zipper"
FT   REGION          175..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          69..110
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        180..202
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  24038 MW;  F42E1642DE4945D6 CRC64;
     MLAGQLEARD PKEGTHPEDP CPGAGAVTEK TAVAAEVLTE DCNAGEMPPL QQQVIRLHQE
     LGRQKSLWAD VHGKLRSHID ALREQNMELR EKLRALQLQR WKARKKSAAS PHAGQESHTL
     ALEPAFGKMS PLSADEETIP KYIGRKNQSA TLLGQFSSSK GDPLCLSSPM SLKIERISSW
     KTPPQEKRDK SLSRRRQDRR ATPTGRPTPC AERRGGV