TCP21_ARATH
ID TCP21_ARATH Reviewed; 239 AA.
AC Q9FTA2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transcription factor TCP21;
DE AltName: Full=Protein CCA1 HIKING EXPEDITION;
DE AltName: Full=Protein CHE;
GN Name=TCP21; Synonyms=CHE; OrderedLocusNames=At5g08330; ORFNames=F8L15.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17307924; DOI=10.1105/tpc.106.048934;
RA Aguilar-Martinez J.A., Poza-Carrion C., Cubas P.;
RT "Arabidopsis BRANCHED1 acts as an integrator of branching signals within
RT axillary buds.";
RL Plant Cell 19:458-472(2007).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH APRR1,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=19286557; DOI=10.1126/science.1167206;
RA Pruneda-Paz J.L., Breton G., Para A., Kay S.A.;
RT "A functional genomics approach reveals CHE as a component of the
RT Arabidopsis circadian clock.";
RL Science 323:1481-1485(2009).
RN [6]
RP INTERACTION WITH SPL.
RX PubMed=25527103; DOI=10.1016/j.jgg.2014.08.009;
RA Chen G.H., Sun J.Y., Liu M., Liu J., Yang W.C.;
RT "SPOROCYTELESS is a novel embryophyte-specific transcription repressor that
RT interacts with TPL and TCP proteins in Arabidopsis.";
RL J. Genet. Genomics 41:617-625(2014).
CC -!- FUNCTION: Transcription factor involved in the regulation of the
CC circadian clock. Acts as a repressor of CCA1 by binding to its
CC promoter. No binding to the LHY promoter.
CC {ECO:0000269|PubMed:19286557}.
CC -!- SUBUNIT: Interacts (via N-terminus) with APRR1/TOC1 (PubMed:19286557).
CC Interacts with SPL (PubMed:25527103). {ECO:0000269|PubMed:19286557,
CC ECO:0000269|PubMed:25527103}.
CC -!- INTERACTION:
CC Q9FTA2; Q9SLA1: At2g25620; NbExp=3; IntAct=EBI-4426168, EBI-15193303;
CC Q9FTA2; Q8S307: BZR1; NbExp=5; IntAct=EBI-4426168, EBI-1803261;
CC Q9FTA2; O80340: ERF4; NbExp=5; IntAct=EBI-4426168, EBI-966009;
CC Q9FTA2; Q9MAI5: ERF8; NbExp=3; IntAct=EBI-4426168, EBI-2000137;
CC Q9FTA2; Q38828: IAA10; NbExp=3; IntAct=EBI-4426168, EBI-3946434;
CC Q9FTA2; A0A2H1ZEF6: IAA15; NbExp=3; IntAct=EBI-4426168, EBI-25524519;
CC Q9FTA2; O24407: IAA16; NbExp=3; IntAct=EBI-4426168, EBI-632231;
CC Q9FTA2; P93830: IAA17; NbExp=3; IntAct=EBI-4426168, EBI-632243;
CC Q9FTA2; P33077: IAA4; NbExp=3; IntAct=EBI-4426168, EBI-632187;
CC Q9FTA2; Q9LUA3: NIMIN-2; NbExp=3; IntAct=EBI-4426168, EBI-541107;
CC Q9FTA2; Q9FNZ4: NIMIN-3; NbExp=3; IntAct=EBI-4426168, EBI-541115;
CC Q9FTA2; Q84MC7: PYL9; NbExp=3; IntAct=EBI-4426168, EBI-2349513;
CC Q9FTA2; Q93Z00: TCP14; NbExp=3; IntAct=EBI-4426168, EBI-4424563;
CC Q9FTA2; Q9LT89: TCP19; NbExp=3; IntAct=EBI-4426168, EBI-4426178;
CC Q9FTA2; Q9C518: TCP8; NbExp=3; IntAct=EBI-4426168, EBI-3134124;
CC Q9FTA2; O64647: TCP9; NbExp=3; IntAct=EBI-4426168, EBI-9838721;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00701,
CC ECO:0000269|PubMed:19286557}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves, roots, and stems.
CC {ECO:0000269|PubMed:19286557}.
CC -!- DISRUPTION PHENOTYPE: No effect on the period length or phase of the
CC circadian clock. {ECO:0000269|PubMed:19286557}.
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DR EMBL; AL392174; CAC08333.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91284.1; -; Genomic_DNA.
DR EMBL; AF412074; AAL06527.1; -; mRNA.
DR EMBL; AY072620; AAL62011.1; -; mRNA.
DR RefSeq; NP_196450.1; NM_120916.3.
DR AlphaFoldDB; Q9FTA2; -.
DR BioGRID; 16008; 130.
DR IntAct; Q9FTA2; 118.
DR STRING; 3702.AT5G08330.1; -.
DR PaxDb; Q9FTA2; -.
DR PRIDE; Q9FTA2; -.
DR ProteomicsDB; 234202; -.
DR EnsemblPlants; AT5G08330.1; AT5G08330.1; AT5G08330.
DR GeneID; 830730; -.
DR Gramene; AT5G08330.1; AT5G08330.1; AT5G08330.
DR KEGG; ath:AT5G08330; -.
DR Araport; AT5G08330; -.
DR TAIR; locus:2150803; AT5G08330.
DR eggNOG; ENOG502QSSR; Eukaryota.
DR HOGENOM; CLU_100757_0_0_1; -.
DR InParanoid; Q9FTA2; -.
DR OMA; TLFVRHQ; -.
DR OrthoDB; 1328785at2759; -.
DR PhylomeDB; Q9FTA2; -.
DR PRO; PR:Q9FTA2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FTA2; baseline and differential.
DR Genevisible; Q9FTA2; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IMP:UniProtKB.
DR GO; GO:0042753; P:positive regulation of circadian rhythm; IMP:TAIR.
DR GO; GO:0042752; P:regulation of circadian rhythm; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR InterPro; IPR017887; TF_TCP_subgr.
DR InterPro; IPR005333; Transcription_factor_TCP.
DR PANTHER; PTHR31072; PTHR31072; 1.
DR Pfam; PF03634; TCP; 1.
DR PROSITE; PS51369; TCP; 1.
PE 1: Evidence at protein level;
KW Biological rhythms; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..239
FT /note="Transcription factor TCP21"
FT /id="PRO_0000330795"
FT DOMAIN 31..85
FT /note="TCP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00701"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 24752 MW; C0AF9BBF8A841565 CRC64;
MADNDGAVSN GIIVEQTSNK GPLNAVKKPP SKDRHSKVDG RGRRIRMPII CAARVFQLTR
ELGHKSDGQT IEWLLRQAEP SIIAATGTGT TPASFSTASL STSSPFTLGK RVVRAEEGES
GGGGGGGLTV GHTMGTSLMG GGGSGGFWAV PARPDFGQVW SFATGAPPEM VFAQQQQPAT
LFVRHQQQQQ ASAAAAAAMG EASAARVGNY LPGHHLNLLA SLSGGANGSG RREDDHEPR
