TCP24_ARATH
ID TCP24_ARATH Reviewed; 324 AA.
AC Q9C758;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transcription factor TCP24;
GN Name=TCP24; OrderedLocusNames=At1g30210; ORFNames=F12P21.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17307924; DOI=10.1105/tpc.106.048934;
RA Aguilar-Martinez J.A., Poza-Carrion C., Cubas P.;
RT "Arabidopsis BRANCHED1 acts as an integrator of branching signals within
RT axillary buds.";
RL Plant Cell 19:458-472(2007).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17307931; DOI=10.1105/tpc.106.044792;
RA Koyama T., Furutani M., Tasaka M., Ohme-Takagi M.;
RT "TCP transcription factors control the morphology of shoot lateral organs
RT via negative regulation of the expression of boundary-specific genes in
RT Arabidopsis.";
RL Plant Cell 19:473-484(2007).
RN [6]
RP FUNCTION, AND IDENTIFICATION IN ABAP1-TCP24 COMPLEX.
RX PubMed=18818695; DOI=10.1038/emboj.2008.191;
RA Masuda H.P., Cabral L.M., De Veylder L., Tanurdzic M.,
RA de Almeida Engler J., Geelen D., Inze D., Martienssen R.A., Ferreira P.C.,
RA Hemerly A.S.;
RT "ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication
RT and transcription.";
RL EMBO J. 27:2746-2756(2008).
RN [7]
RP INTERACTION WITH SPL.
RX PubMed=25527103; DOI=10.1016/j.jgg.2014.08.009;
RA Chen G.H., Sun J.Y., Liu M., Liu J., Yang W.C.;
RT "SPOROCYTELESS is a novel embryophyte-specific transcription repressor that
RT interacts with TPL and TCP proteins in Arabidopsis.";
RL J. Genet. Genomics 41:617-625(2014).
RN [8]
RP FUNCTION, INTERACTION WITH SPL, AND DEVELOPMENTAL STAGE.
RX PubMed=25378179; DOI=10.1038/cr.2014.145;
RA Wei B., Zhang J., Pang C., Yu H., Guo D., Jiang H., Ding M., Chen Z.,
RA Tao Q., Gu H., Qu L.J., Qin G.;
RT "The molecular mechanism of sporocyteless/nozzle in controlling Arabidopsis
RT ovule development.";
RL Cell Res. 25:121-134(2015).
CC -!- FUNCTION: Plays a pivotal role in the control of morphogenesis of shoot
CC organs by negatively regulating the expression of boundary-specific
CC genes such as CUC genes, probably through the induction of miRNA (e.g.
CC miR164). In association with ABAP1, exerts a negative role in cell
CC proliferation in leaves, possibly by inhibiting mitotic DNA
CC replication. Participates in ovule develpment (PubMed:25378179).
CC {ECO:0000269|PubMed:17307931, ECO:0000269|PubMed:18818695,
CC ECO:0000269|PubMed:25378179}.
CC -!- SUBUNIT: Forms a heterodimeric complex with ABAP1 (PubMed:18818695).
CC Interacts with SPL (PubMed:25527103, PubMed:25378179).
CC {ECO:0000269|PubMed:18818695, ECO:0000269|PubMed:25378179,
CC ECO:0000269|PubMed:25527103}.
CC -!- INTERACTION:
CC Q9C758; B7U179: ABAP1; NbExp=4; IntAct=EBI-8079833, EBI-541722;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in cotyledons, particularly in the
CC vascular region, in leaves, roots, stems, buds, flowers and siliques.
CC {ECO:0000269|PubMed:17307931}.
CC -!- DEVELOPMENTAL STAGE: Expressed during ovule development
CC (PubMed:25378179). {ECO:0000269|PubMed:25378179}.
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DR EMBL; AC073506; AAG50562.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31192.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31193.1; -; Genomic_DNA.
DR EMBL; AY035008; AAK59513.1; -; mRNA.
DR EMBL; AY057672; AAL15303.1; -; mRNA.
DR EMBL; AY113898; AAM44946.1; -; mRNA.
DR PIR; C86426; C86426.
DR RefSeq; NP_564351.1; NM_102760.3.
DR RefSeq; NP_849730.1; NM_179399.3.
DR AlphaFoldDB; Q9C758; -.
DR SMR; Q9C758; -.
DR BioGRID; 25136; 18.
DR IntAct; Q9C758; 2.
DR MINT; Q9C758; -.
DR STRING; 3702.AT1G30210.1; -.
DR PaxDb; Q9C758; -.
DR PRIDE; Q9C758; -.
DR ProteomicsDB; 234149; -.
DR EnsemblPlants; AT1G30210.1; AT1G30210.1; AT1G30210.
DR EnsemblPlants; AT1G30210.2; AT1G30210.2; AT1G30210.
DR GeneID; 839901; -.
DR Gramene; AT1G30210.1; AT1G30210.1; AT1G30210.
DR Gramene; AT1G30210.2; AT1G30210.2; AT1G30210.
DR KEGG; ath:AT1G30210; -.
DR Araport; AT1G30210; -.
DR TAIR; locus:2009797; AT1G30210.
DR eggNOG; ENOG502QQFU; Eukaryota.
DR HOGENOM; CLU_036572_0_0_1; -.
DR InParanoid; Q9C758; -.
DR OMA; QETDIAH; -.
DR OrthoDB; 1110972at2759; -.
DR PhylomeDB; Q9C758; -.
DR PRO; PR:Q9C758; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C758; baseline and differential.
DR Genevisible; Q9C758; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IPI:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IGI:UniProtKB.
DR GO; GO:2000032; P:regulation of secondary shoot formation; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR017888; CYC/TB1_R_domain.
DR InterPro; IPR017887; TF_TCP_subgr.
DR InterPro; IPR005333; Transcription_factor_TCP.
DR PANTHER; PTHR31072; PTHR31072; 1.
DR Pfam; PF03634; TCP; 1.
DR PROSITE; PS51370; R; 1.
DR PROSITE; PS51369; TCP; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..324
FT /note="Transcription factor TCP24"
FT /id="PRO_0000330798"
FT DOMAIN 50..108
FT /note="TCP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00701"
FT DOMAIN 144..162
FT /note="R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00702"
FT REGION 122..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 36377 MW; 0AE0E392AC993A82 CRC64;
MEVDEDIELQ KHQEQQSRKL QRFSEDNTGL MRNWNNPSSR IIRVSRASGG KDRHSKVLTS
KGLRDRRIRL SVATAIQFYD LQDRLGFDQP SKAVEWLINA ASDSITDLPL LNTNFDHLDQ
NQNQTKSACS SGTSESSLLS LSRTEIRGKA RERARERTAK DRDKDLQNAH SSFTQLLTGG
FDQQPSNRNW TGGSDCFNPV QLQIPNSSSQ EPMNHPFSFV PDYNFGISSS SSAINGGYSS
RGTLQSNSQS LFLNNNNNIT QRSSISSSSS SSSPMDSQSI SFFMATPPPL DHHNHQLPET
FDGRLYLYYG EGNRSSDDKA KERR