TCP3_ARATH
ID TCP3_ARATH Reviewed; 391 AA.
AC Q9MAH8; O81369;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transcription factor TCP3;
GN Name=TCP3; OrderedLocusNames=At1g53230; ORFNames=F12M16.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-391.
RA Doebley J., Lauter N., Stec A.;
RT "Arabidopsis EST (Accession T45419) with homology to teosinte branched.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP DEVELOPMENTAL STAGE.
RX PubMed=10363373; DOI=10.1046/j.1365-313x.1999.00444.x;
RA Cubas P., Lauter N., Doebley J., Coen E.;
RT "The TCP domain: a motif found in proteins regulating plant growth and
RT development.";
RL Plant J. 18:215-222(1999).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17307924; DOI=10.1105/tpc.106.048934;
RA Aguilar-Martinez J.A., Poza-Carrion C., Cubas P.;
RT "Arabidopsis BRANCHED1 acts as an integrator of branching signals within
RT axillary buds.";
RL Plant Cell 19:458-472(2007).
RN [7]
RP FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=17307931; DOI=10.1105/tpc.106.044792;
RA Koyama T., Furutani M., Tasaka M., Ohme-Takagi M.;
RT "TCP transcription factors control the morphology of shoot lateral organs
RT via negative regulation of the expression of boundary-specific genes in
RT Arabidopsis.";
RL Plant Cell 19:473-484(2007).
RN [8]
RP INTERACTION WITH SPL.
RX PubMed=25527103; DOI=10.1016/j.jgg.2014.08.009;
RA Chen G.H., Sun J.Y., Liu M., Liu J., Yang W.C.;
RT "SPOROCYTELESS is a novel embryophyte-specific transcription repressor that
RT interacts with TPL and TCP proteins in Arabidopsis.";
RL J. Genet. Genomics 41:617-625(2014).
RN [9]
RP FUNCTION, INTERACTION WITH SPL, AND DEVELOPMENTAL STAGE.
RX PubMed=25378179; DOI=10.1038/cr.2014.145;
RA Wei B., Zhang J., Pang C., Yu H., Guo D., Jiang H., Ding M., Chen Z.,
RA Tao Q., Gu H., Qu L.J., Qin G.;
RT "The molecular mechanism of sporocyteless/nozzle in controlling Arabidopsis
RT ovule development.";
RL Cell Res. 25:121-134(2015).
RN [10]
RP INTERACTION WITH KIN10; KIN11 AND FLZ3.
RX DOI=10.1016/j.cpb.2015.10.004;
RA Nietzsche M., Landgraf R., Tohge T., Boernke F.;
RT "A protein-protein interaction network linking the energy-sensor kinase
RT SnRK1 to multiple signaling pathways in Arabidopsis thaliana.";
RL Curr. Plant Biol. 5:36-44(2016).
CC -!- FUNCTION: Plays a pivotal role in the control of morphogenesis of shoot
CC organs by negatively regulating the expression of boundary-specific
CC genes such as CUC genes, probably through the induction of miRNA (e.g.
CC miR164). Participates in ovule develpment (PubMed:25378179).
CC {ECO:0000269|PubMed:17307931, ECO:0000269|PubMed:25378179}.
CC -!- SUBUNIT: Interacts with SPL. Interacts with KIN10; KIN11 and FLZ3
CC (Ref.10). {ECO:0000269|PubMed:25378179, ECO:0000269|PubMed:25527103,
CC ECO:0000269|Ref.10}.
CC -!- INTERACTION:
CC Q9MAH8; O80366: ARR9; NbExp=3; IntAct=EBI-25522447, EBI-1100950;
CC Q9MAH8; Q9ZT48: ATE1; NbExp=3; IntAct=EBI-25522447, EBI-25522944;
CC Q9MAH8; Q8S307: BZR1; NbExp=3; IntAct=EBI-25522447, EBI-1803261;
CC Q9MAH8; Q9C5I3: ERF11; NbExp=3; IntAct=EBI-25522447, EBI-25523668;
CC Q9MAH8; Q94ID6: ERF12; NbExp=3; IntAct=EBI-25522447, EBI-4446727;
CC Q9MAH8; O80340: ERF4; NbExp=3; IntAct=EBI-25522447, EBI-966009;
CC Q9MAH8; Q9MAI5: ERF8; NbExp=3; IntAct=EBI-25522447, EBI-2000137;
CC Q9MAH8; Q9FE67: ERF9; NbExp=3; IntAct=EBI-25522447, EBI-4431933;
CC Q9MAH8; Q9LRH6: GATA25; NbExp=3; IntAct=EBI-25522447, EBI-2460434;
CC Q9MAH8; Q38828: IAA10; NbExp=3; IntAct=EBI-25522447, EBI-3946434;
CC Q9MAH8; A0A2H1ZEF6: IAA15; NbExp=3; IntAct=EBI-25522447, EBI-25524519;
CC Q9MAH8; O24407: IAA16; NbExp=3; IntAct=EBI-25522447, EBI-632231;
CC Q9MAH8; P93830: IAA17; NbExp=3; IntAct=EBI-25522447, EBI-632243;
CC Q9MAH8; O24409: IAA19; NbExp=3; IntAct=EBI-25522447, EBI-632257;
CC Q9MAH8; O24410: IAA20; NbExp=3; IntAct=EBI-25522447, EBI-632272;
CC Q9MAH8; Q9ZSY8: IAA27; NbExp=3; IntAct=EBI-25522447, EBI-3946677;
CC Q9MAH8; Q9XFM0: IAA28; NbExp=3; IntAct=EBI-25522447, EBI-3133404;
CC Q9MAH8; Q38822: IAA3; NbExp=3; IntAct=EBI-25522447, EBI-307174;
CC Q9MAH8; Q8RYC6: IAA32; NbExp=3; IntAct=EBI-25522447, EBI-3946448;
CC Q9MAH8; Q9FKM7: IAA33; NbExp=3; IntAct=EBI-25522447, EBI-3946739;
CC Q9MAH8; Q9C5X0: IAA34; NbExp=3; IntAct=EBI-25522447, EBI-3946459;
CC Q9MAH8; P33078: IAA5; NbExp=3; IntAct=EBI-25522447, EBI-3946487;
CC Q9MAH8; Q38824: IAA6; NbExp=3; IntAct=EBI-25522447, EBI-1554124;
CC Q9MAH8; Q38826: IAA8; NbExp=3; IntAct=EBI-25522447, EBI-632200;
CC Q9MAH8; Q38827: IAA9; NbExp=3; IntAct=EBI-25522447, EBI-632216;
CC Q9MAH8; Q9FNZ5: NIMIN-1; NbExp=3; IntAct=EBI-25522447, EBI-541099;
CC Q9MAH8; Q9LUA3: NIMIN-2; NbExp=3; IntAct=EBI-25522447, EBI-541107;
CC Q9MAH8; Q9FNZ4: NIMIN-3; NbExp=3; IntAct=EBI-25522447, EBI-541115;
CC Q9MAH8; Q8S8E3: PYL6; NbExp=3; IntAct=EBI-25522447, EBI-2363192;
CC Q9MAH8; Q84MC7: PYL9; NbExp=3; IntAct=EBI-25522447, EBI-2349513;
CC Q9MAH8; Q9SLH3: RGA; NbExp=3; IntAct=EBI-25522447, EBI-963624;
CC Q9MAH8; Q9LMA8: TIFY10A; NbExp=3; IntAct=EBI-25522447, EBI-1388539;
CC Q9MAH8; Q9S7M2: TIFY10B; NbExp=3; IntAct=EBI-25522447, EBI-1792563;
CC Q9MAH8; Q9LVI4: TIFY6B; NbExp=3; IntAct=EBI-25522447, EBI-1792431;
CC Q9MAH8; Q8W4J8: TIFY7; NbExp=3; IntAct=EBI-25522447, EBI-1792583;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in cotyledons, particularly in the
CC vascular region, in leaves, roots, buds, flowers and immature siliques.
CC {ECO:0000269|PubMed:17307931}.
CC -!- DEVELOPMENTAL STAGE: First observed in the distal and middle regions of
CC cotyledons of torpedo-shaped embryos. Later localized in bending
CC cotyledon, and mature embryos, but no signals were detected in the
CC presumptive shoot apical meristem (SAM) and the boundary region during
CC embryogenesis. During flower development, first observed throughout the
CC floral meristem. Later expressed in rapidly growing floral primordia.
CC Detected to a lower extent in vegetative primordia. During flower
CC development, first observed throughout the floral meristem. Expressed
CC during ovule development (PubMed:25378179).
CC {ECO:0000269|PubMed:10363373, ECO:0000269|PubMed:17307931,
CC ECO:0000269|PubMed:25378179}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC24010.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC008007; AAF69550.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32909.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60190.1; -; Genomic_DNA.
DR EMBL; AY099678; AAM20529.1; -; mRNA.
DR EMBL; BT000266; AAN15585.1; -; mRNA.
DR EMBL; AF072134; AAC24010.1; ALT_INIT; mRNA.
DR PIR; H96572; H96572.
DR PIR; T52182; T52182.
DR RefSeq; NP_001322492.1; NM_001333584.1.
DR RefSeq; NP_564624.2; NM_104201.3.
DR AlphaFoldDB; Q9MAH8; -.
DR SMR; Q9MAH8; -.
DR BioGRID; 26981; 73.
DR IntAct; Q9MAH8; 35.
DR STRING; 3702.AT1G53230.1; -.
DR PaxDb; Q9MAH8; -.
DR PRIDE; Q9MAH8; -.
DR ProteomicsDB; 234385; -.
DR DNASU; 841756; -.
DR EnsemblPlants; AT1G53230.1; AT1G53230.1; AT1G53230.
DR EnsemblPlants; AT1G53230.2; AT1G53230.2; AT1G53230.
DR GeneID; 841756; -.
DR Gramene; AT1G53230.1; AT1G53230.1; AT1G53230.
DR Gramene; AT1G53230.2; AT1G53230.2; AT1G53230.
DR KEGG; ath:AT1G53230; -.
DR Araport; AT1G53230; -.
DR TAIR; locus:2009595; AT1G53230.
DR eggNOG; ENOG502QRP9; Eukaryota.
DR HOGENOM; CLU_033594_0_0_1; -.
DR InParanoid; Q9MAH8; -.
DR OMA; QSINTPM; -.
DR OrthoDB; 889972at2759; -.
DR PhylomeDB; Q9MAH8; -.
DR PRO; PR:Q9MAH8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9MAH8; baseline and differential.
DR Genevisible; Q9MAH8; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048366; P:leaf development; IGI:TAIR.
DR GO; GO:0010150; P:leaf senescence; IGI:TAIR.
DR GO; GO:2000032; P:regulation of secondary shoot formation; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009733; P:response to auxin; IMP:TAIR.
DR InterPro; IPR017887; TF_TCP_subgr.
DR InterPro; IPR005333; Transcription_factor_TCP.
DR PANTHER; PTHR31072; PTHR31072; 1.
DR Pfam; PF03634; TCP; 1.
DR PROSITE; PS51369; TCP; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..391
FT /note="Transcription factor TCP3"
FT /id="PRO_0000330777"
FT DOMAIN 49..107
FT /note="TCP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00701"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 43044 MW; F2C82F8C367F1CAD CRC64;
MAPDNDHFLD SPSPPLLEMR HHQSATENGG GCGEIVEVQG GHIVRSTGRK DRHSKVCTAK
GPRDRRVRLS APTAIQFYDV QDRLGFDRPS KAVDWLITKA KSAIDDLAQL PPWNPADTLR
QHAAAAANAK PRKTKTLISP PPPQPEETEH HRIGEEEDNE SSFLPASMDS DSIADTIKSF
FPVASTQQSY HHQPPSRGNT QNQDLLRLSL QSFQNGPPFP NQTEPALFSG QSNNQLAFDS
STASWEQSHQ SPEFGKIQRL VSWNNVGAAE SAGSTGGFVF ASPSSLHPVY SQSQLLSQRG
PLQSINTPMI RAWFDPHHHH HHHQQSMTTD DLHHHHPYHI PPGIHQSAIP GIAFASSGEF
SGFRIPARFQ GEQEEHGGDN KPSSASSDSR H
