ID   TCP4_CAEEL              Reviewed;         124 AA.
AC   Q94045;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Putative RNA polymerase II transcriptional coactivator;
GN   ORFNames=T13F2.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: General coactivator that functions cooperatively with TAFs
CC       and mediates functional interactions between upstream activators and
CC       the general transcriptional machinery. Binds single-stranded DNA (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transcriptional coactivator PC4 family.
CC       {ECO:0000305}.
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DR   EMBL; Z81122; CAB03353.1; -; Genomic_DNA.
DR   PIR; T24876; T24876.
DR   RefSeq; NP_501750.1; NM_069349.6.
DR   AlphaFoldDB; Q94045; -.
DR   SMR; Q94045; -.
DR   BioGRID; 53139; 3.
DR   STRING; 6239.T13F2.2; -.
DR   iPTMnet; Q94045; -.
DR   EPD; Q94045; -.
DR   PaxDb; Q94045; -.
DR   PeptideAtlas; Q94045; -.
DR   EnsemblMetazoa; T13F2.2.1; T13F2.2.1; WBGene00011743.
DR   GeneID; 188475; -.
DR   KEGG; cel:CELE_T13F2.2; -.
DR   UCSC; T13F2.2.1; c. elegans.
DR   CTD; 188475; -.
DR   WormBase; T13F2.2; CE13621; WBGene00011743; -.
DR   eggNOG; KOG2712; Eukaryota.
DR   GeneTree; ENSGT00390000008802; -.
DR   HOGENOM; CLU_104273_1_2_1; -.
DR   InParanoid; Q94045; -.
DR   OMA; QWANLKD; -.
DR   OrthoDB; 1616655at2759; -.
DR   PhylomeDB; Q94045; -.
DR   PRO; PR:Q94045; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00011743; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IDA:WormBase.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   GO; GO:0001111; P:promoter clearance from RNA polymerase II promoter; IDA:WormBase.
DR   Gene3D; 2.30.31.10; -; 1.
DR   InterPro; IPR003173; PC4_C.
DR   InterPro; IPR009044; ssDNA-bd_transcriptional_reg.
DR   InterPro; IPR045125; Sub1/Tcp4-like.
DR   PANTHER; PTHR13215; PTHR13215; 1.
DR   Pfam; PF02229; PC4; 1.
DR   SUPFAM; SSF54447; SSF54447; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..124
FT                   /note="Putative RNA polymerase II transcriptional
FT                   coactivator"
FT                   /id="PRO_0000215945"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   124 AA;  14446 MW;  1858475E1A659D91 CRC64;
     MSSSSSSEDE LEKKVTKEQK KKETKSKKRQ SEAVEEEKQE VKKAKNEEEV SGRLKDSDGN
     EMFEIGNLRY ATVSKFKGKE YVNIREYYID RDSQKMMPSR KGISLSKAQW ANLKDLIPEI
     DKKF