ID   TCP4_CHICK              Reviewed;         126 AA.
AC   Q5ZK63;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Activated RNA polymerase II transcriptional coactivator p15;
DE   AltName: Full=SUB1 homolog;
GN   Name=SUB1; Synonyms=RPO2TC1; ORFNames=RCJMB04_12p22;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: General coactivator that functions cooperatively with TAFs
CC       and mediates functional interactions between upstream activators and
CC       the general transcriptional machinery. May be involved in stabilizing
CC       the multiprotein transcription complex. Binds single-stranded DNA. Also
CC       binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transcriptional coactivator PC4 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ720221; CAG31880.1; -; mRNA.
DR   RefSeq; NP_001008479.1; NM_001008479.1.
DR   AlphaFoldDB; Q5ZK63; -.
DR   SMR; Q5ZK63; -.
DR   STRING; 9031.ENSGALP00000005126; -.
DR   Ensembl; ENSGALT00000005135; ENSGALP00000005126; ENSGALG00000003248.
DR   GeneID; 427425; -.
DR   KEGG; gga:427425; -.
DR   CTD; 10923; -.
DR   VEuPathDB; HostDB:geneid_427425; -.
DR   eggNOG; KOG2712; Eukaryota.
DR   GeneTree; ENSGT00390000008802; -.
DR   HOGENOM; CLU_104273_1_1_1; -.
DR   InParanoid; Q5ZK63; -.
DR   OMA; WMNPDGE; -.
DR   OrthoDB; 1616655at2759; -.
DR   PhylomeDB; Q5ZK63; -.
DR   PRO; PR:Q5ZK63; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   Bgee; ENSGALG00000003248; Expressed in brain and 14 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IBA:GO_Central.
DR   Gene3D; 2.30.31.10; -; 1.
DR   InterPro; IPR003173; PC4_C.
DR   InterPro; IPR009044; ssDNA-bd_transcriptional_reg.
DR   InterPro; IPR045125; Sub1/Tcp4-like.
DR   PANTHER; PTHR13215; PTHR13215; 1.
DR   Pfam; PF02229; PC4; 1.
DR   SUPFAM; SSF54447; SSF54447; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..126
FT                   /note="Activated RNA polymerase II transcriptional
FT                   coactivator p15"
FT                   /id="PRO_0000291885"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2..50
FT                   /note="Regulatory"
FT                   /evidence="ECO:0000250"
FT   REGION          76..100
FT                   /note="Interaction with ssDNA"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   126 AA;  14237 MW;  13763AC004777739 CRC64;
     MPKSKELVSS SSSASDSDSE VDKKAKRKKQ AAPEKPVKKQ KTGESSKGAA SSKQSSNRDE
     NMFQIGKMRY VSVRDFKGKV LIDIREYWMD QEGEMKPGRK GISLNPEQWN QLKEQISDID
     DAVRKL