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BQMT2_ORYSJ
ID   BQMT2_ORYSJ             Reviewed;         348 AA.
AC   Q2QM69; A0A0P0YD53;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=2-methyl-6-phytyl-1,4-hydroquinone methyltransferase 2, chloroplastic;
DE            EC=2.1.1.295;
DE   AltName: Full=37 kDa inner envelope membrane protein;
DE            Short=E37;
DE   AltName: Full=MPBQ/MSBQ methyltransferase;
DE   AltName: Full=Protein VTE3 homolog;
DE   Flags: Precursor;
GN   OrderedLocusNames=Os12g0615400, LOC_Os12g42090; ORFNames=OsJ_36874;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Involved in a key methylation step in both tocopherols
CC       (vitamin E) and plastoquinone synthesis. Catalyzes the conversion of 2-
CC       methyl-6-phytyl-1,4-hydroquinone (MPBQ) to 2,3-dimethyl-6-phytyl-1,4-
CC       hydroquinone (DMPQ, a substrate for tocopherol cyclase), and 2-methyl-
CC       6-solanyl-1,4-benzoquinone (MSBQ) to plastoquinone (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-methyl-6-phytyl-1,4-benzene-1,4-diol + S-adenosyl-L-
CC         methionine = 2,3-dimethyl-6-phytylbenzene-1,4-diol + H(+) + S-
CC         adenosyl-L-homocysteine; Xref=Rhea:RHEA:37979, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:75920,
CC         ChEBI:CHEBI:75921; EC=2.1.1.295;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + S-adenosyl-
CC         L-methionine = H(+) + plastoquinol-9 + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:37999, ChEBI:CHEBI:15378, ChEBI:CHEBI:28026,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:75402;
CC         EC=2.1.1.295;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-geranylgeranyl-2-methylbenzene-1,4-diol + S-adenosyl-L-
CC         methionine = 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol + H(+) +
CC         S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:38007, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:75411,
CC         ChEBI:CHEBI:75412; EC=2.1.1.295;
CC   -!- PATHWAY: Cofactor biosynthesis; tocopherol biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC       {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. MPBQ/MBSQ MT family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01069}.
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DR   EMBL; DP000011; ABA99849.2; -; Genomic_DNA.
DR   EMBL; AP008218; BAF30293.1; -; Genomic_DNA.
DR   EMBL; AP014968; BAT18091.1; -; Genomic_DNA.
DR   EMBL; CM000149; EAZ21221.1; -; Genomic_DNA.
DR   EMBL; AK072988; BAG93239.1; -; mRNA.
DR   EMBL; AK104295; BAG96579.1; -; mRNA.
DR   EMBL; AK105795; BAG97369.1; -; mRNA.
DR   RefSeq; XP_015619522.1; XM_015764036.1.
DR   AlphaFoldDB; Q2QM69; -.
DR   SMR; Q2QM69; -.
DR   STRING; 4530.OS12T0615400-01; -.
DR   PRIDE; Q2QM69; -.
DR   EnsemblPlants; Os12t0615400-01; Os12t0615400-01; Os12g0615400.
DR   GeneID; 4352791; -.
DR   Gramene; Os12t0615400-01; Os12t0615400-01; Os12g0615400.
DR   KEGG; osa:4352791; -.
DR   eggNOG; KOG1540; Eukaryota.
DR   HOGENOM; CLU_051421_0_0_1; -.
DR   InParanoid; Q2QM69; -.
DR   OMA; IACVIGP; -.
DR   UniPathway; UPA00160; -.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000007752; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   Genevisible; Q2QM69; OS.
DR   GO; GO:0009706; C:chloroplast inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0102550; F:2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051741; F:2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity; IEA:InterPro.
DR   GO; GO:0051742; F:2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity; IEA:RHEA.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0010189; P:vitamin E biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR041698; Methyltransf_25.
DR   InterPro; IPR044649; MPBQ/MSBQ_MT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR031164; SAM_MPBQ_MSBQ_MT.
DR   PANTHER; PTHR44516; PTHR44516; 1.
DR   Pfam; PF13649; Methyltransf_25; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51734; SAM_MPBQ_MSBQ_MT; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Membrane; Methyltransferase; Plastid; Plastid inner membrane;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..59
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           60..348
FT                   /note="2-methyl-6-phytyl-1,4-hydroquinone methyltransferase
FT                   2, chloroplastic"
FT                   /id="PRO_0000422878"
FT   TOPO_DOM        60..317
FT                   /note="Chloroplast intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        339..348
FT                   /note="Stromal"
FT                   /evidence="ECO:0000255"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..134
FT                   /note="SAM motif I"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01069"
FT   REGION          170..183
FT                   /note="SAM motif II"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01069"
FT   REGION          211..224
FT                   /note="SAM motif III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01069"
SQ   SEQUENCE   348 AA;  38940 MW;  18F535292D462CC5 CRC64;
     MAMASSAYAP AGGVGTHSAP GRIRPPRGLG FSTTTTKSRP LVLTRRGGGG GNISVARLRC
     AASSSSAAAR PMSQPRFIQH KKEAFWFYRF LSIVYDHVIN PGHWTEDMRD DALEPADLYS
     RKLRVVDVGG GTGFTTLGIV KRVDPENVTL LDQSPHQLEK AREKEALKGV TIMEGDAEDL
     PFPTDTFDRY VSAGSIEYWP DPQRGIKEAY RVLRLGGVAC MIGPVHPTFW LSRFFADMWM
     LFPKEEEYIE WFKKAGFKDV KLKRIGPKWY RGVRRHGLIM GCSVTGVKRE HGDSPLQLGP
     KVEDVSKPVN PITFLFRFLM GTICAAYYVL VPIYMWIKDQ IVPKGMPI
 
 
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