TCP8_ARATH
ID TCP8_ARATH Reviewed; 401 AA.
AC Q9C518; A8MQM9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transcription factor TCP8;
GN Name=TCP8; OrderedLocusNames=At1g58100; ORFNames=T15M6.11, T18I24.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17307924; DOI=10.1105/tpc.106.048934;
RA Aguilar-Martinez J.A., Poza-Carrion C., Cubas P.;
RT "Arabidopsis BRANCHED1 acts as an integrator of branching signals within
RT axillary buds.";
RL Plant Cell 19:458-472(2007).
RN [5]
RP INTERACTION WITH PP438/PNM1, AND FUNCTION.
RX PubMed=21297037; DOI=10.1105/tpc.110.081638;
RA Hammani K., Gobert A., Hleibieh K., Choulier L., Small I., Giege P.;
RT "An Arabidopsis dual-localized pentatricopeptide repeat protein interacts
RT with nuclear proteins involved in gene expression regulation.";
RL Plant Cell 23:730-740(2011).
RN [6]
RP INTERACTION WITH SPL.
RX PubMed=25527103; DOI=10.1016/j.jgg.2014.08.009;
RA Chen G.H., Sun J.Y., Liu M., Liu J., Yang W.C.;
RT "SPOROCYTELESS is a novel embryophyte-specific transcription repressor that
RT interacts with TPL and TCP proteins in Arabidopsis.";
RL J. Genet. Genomics 41:617-625(2014).
CC -!- FUNCTION: Can specifically bind site II elements in the promoter region
CC of PP438/PNM1. {ECO:0000269|PubMed:21297037}.
CC -!- SUBUNIT: Interacts with PP438/PNM1 (PubMed:21297037). Interacts with
CC SPL (PubMed:25527103). {ECO:0000269|PubMed:21297037,
CC ECO:0000269|PubMed:25527103}.
CC -!- INTERACTION:
CC Q9C518; O04292: ATHB-9; NbExp=4; IntAct=EBI-3134124, EBI-1536772;
CC Q9C518; Q9ZVC9: FRS3; NbExp=4; IntAct=EBI-3134124, EBI-4448729;
CC Q9C518; Q9FME4: PNM1; NbExp=4; IntAct=EBI-3134124, EBI-6913662;
CC Q9C518; Q93Z00: TCP14; NbExp=4; IntAct=EBI-3134124, EBI-4424563;
CC Q9C518; Q9C9L2: TCP15; NbExp=4; IntAct=EBI-3134124, EBI-4426144;
CC Q9C518; Q9FTA2: TCP21; NbExp=3; IntAct=EBI-3134124, EBI-4426168;
CC Q9C518; Q9LQF0: TCP23; NbExp=3; IntAct=EBI-3134124, EBI-15192297;
CC Q9C518; Q9LDT3: YAB4; NbExp=3; IntAct=EBI-3134124, EBI-1115523;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9C518-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9C518-2; Sequence=VSP_033115;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC079131; AAG50759.1; -; Genomic_DNA.
DR EMBL; AC079604; AAG50694.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33497.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33498.1; -; Genomic_DNA.
DR EMBL; AY081344; AAL91233.1; -; mRNA.
DR EMBL; BT008493; AAP37852.1; -; mRNA.
DR PIR; C96614; C96614.
DR RefSeq; NP_001077739.1; NM_001084270.1. [Q9C518-2]
DR RefSeq; NP_176107.1; NM_104592.5. [Q9C518-1]
DR AlphaFoldDB; Q9C518; -.
DR BioGRID; 27402; 84.
DR IntAct; Q9C518; 62.
DR STRING; 3702.AT1G58100.1; -.
DR iPTMnet; Q9C518; -.
DR PaxDb; Q9C518; -.
DR PRIDE; Q9C518; -.
DR ProteomicsDB; 234205; -. [Q9C518-1]
DR EnsemblPlants; AT1G58100.1; AT1G58100.1; AT1G58100. [Q9C518-1]
DR EnsemblPlants; AT1G58100.2; AT1G58100.2; AT1G58100. [Q9C518-2]
DR GeneID; 842177; -.
DR Gramene; AT1G58100.1; AT1G58100.1; AT1G58100. [Q9C518-1]
DR Gramene; AT1G58100.2; AT1G58100.2; AT1G58100. [Q9C518-2]
DR KEGG; ath:AT1G58100; -.
DR Araport; AT1G58100; -.
DR TAIR; locus:2196220; AT1G58100.
DR eggNOG; ENOG502QVJ6; Eukaryota.
DR HOGENOM; CLU_025170_2_1_1; -.
DR InParanoid; Q9C518; -.
DR OMA; MLGYHHH; -.
DR OrthoDB; 1213812at2759; -.
DR PhylomeDB; Q9C518; -.
DR PRO; PR:Q9C518; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C518; baseline and differential.
DR Genevisible; Q9C518; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR017887; TF_TCP_subgr.
DR InterPro; IPR005333; Transcription_factor_TCP.
DR PANTHER; PTHR31072; PTHR31072; 2.
DR Pfam; PF03634; TCP; 1.
DR PROSITE; PS51369; TCP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..401
FT /note="Transcription factor TCP8"
FT /id="PRO_0000330782"
FT DOMAIN 60..114
FT /note="TCP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00701"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 364..389
FT /evidence="ECO:0000255"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 93..116
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033115"
SQ SEQUENCE 401 AA; 42471 MW; 9F5E817CDB11874C CRC64;
MDLSDIRNNN NDTAAVATGG GARQLVDASL SIVPRSTPPE DSTLATTSST ATATTTKRST
KDRHTKVDGR GRRIRMPALC AARVFQLTRE LGHKSDGETI EWLLQQAEPA IVAATGTGTI
PANFSTLSVS LRSSGSTLSA PPSKSVPLYG ALGLTHHQYD EQGGGGVFAA HTSPLLGFHH
QLQHHQNQNQ NQDPVETIPE GENFSRKRYR SVDLSKENDD RKQNENKSLK ESETSGPTAA
PMWAVAPPSR SGAGNTFWML PVPTTAGNQM ESSSNNNTAA GHRAPPMWPF VNSAGGGAGG
GGGAATHFMA GTGFSFPMDQ YRGSPLQLGS FLAQPQPTQN LGLSMPDSNL GMLAALNSAY
SRGGNANANA EQANNAVEHQ EKQQQSDHDD DSREENSNSS E
