ID   TCPA_AMBME              Reviewed;         173 AA.
AC   P50157;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=T-complex protein 1 subunit alpha;
DE            Short=TCP-1-alpha;
DE   AltName: Full=CCT-alpha;
DE   Flags: Fragment;
OS   Ambystoma mexicanum (Axolotl).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX   NCBI_TaxID=8296;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7841192; DOI=10.1016/0167-4781(94)00187-8;
RA   Sun H.B., Neff A.W., Mescher A.L., Malacinski G.M.;
RT   "Expression of the axolotl homologue of mouse chaperonin T-complex protein-
RT   1 during early development.";
RL   Biochim. Biophys. Acta 1260:157-166(1995).
CC   -!- FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a
CC       molecular chaperone complex that assists the folding of proteins upon
CC       ATP hydrolysis. {ECO:0000250|UniProtKB:P17987}.
CC   -!- SUBUNIT: Component of the chaperonin-containing T-complex (TRiC), a
CC       heterooligomeric complex of about 850 to 900 kDa that forms two stacked
CC       rings, 12 to 16 nm in diameter. {ECO:0000250|UniProtKB:P17987}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P17987}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
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DR   EMBL; S77330; AAB34658.2; -; mRNA.
DR   PIR; S52132; S52132.
DR   AlphaFoldDB; P50157; -.
DR   SMR; P50157; -.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   SUPFAM; SSF48592; SSF48592; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding.
FT   CHAIN           <1..>173
FT                   /note="T-complex protein 1 subunit alpha"
FT                   /id="PRO_0000128308"
FT   NON_TER         1
FT   NON_TER         173
SQ   SEQUENCE   173 AA;  19056 MW;  83A3C7920AD7A6EF CRC64;
     FMCDEMERSV HDALCVVKRV LESKSVVPGG GAVEAALSIY LENYATSMGS REQLAIAEFA
     RSLLVIPKTL AVNRAQDSTD LVAKLRAFHN EAQVNPDRKN LKWIGLDLVN GKARDNKQAG
     VFEPTMVKTK SLKFATEAAI TILRIDDLIK LYPESNDKGQ SYQDAVRSGS LEN