BQT1_SCHPO
ID BQT1_SCHPO Reviewed; 132 AA.
AC Q92358; Q2ABX4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Telomere bouquet protein 1;
DE AltName: Full=Meiotic chromosome segregation protein bqt1;
DE AltName: Full=Meiotic recombination protein rec26;
DE AltName: Full=Meiotically up-regulated gene 23 protein;
GN Name=bqt1; Synonyms=mug23, rec26; ORFNames=SPAC6G9.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH BQT2 AND
RP SAD1, AND SUBCELLULAR LOCATION.
RX PubMed=16615890; DOI=10.1016/j.cell.2006.01.048;
RA Chikashige Y., Tsutsumi C., Yamane M., Okamasa K., Haraguchi T.,
RA Hiraoka Y.;
RT "Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet
RT arrangement of chromosomes.";
RL Cell 125:59-69(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in chromosome segregation. During meiotic prophase,
CC connects telomeres to the spindle pole body by forming a bridge between
CC the telomere protein rap1 and the spindle pole body protein sad1.
CC {ECO:0000269|PubMed:16303567, ECO:0000269|PubMed:16615890}.
CC -!- SUBUNIT: Interacts with bqt2 and sad1. The bqt1-bqt2-sad1 complex binds
CC rap1. {ECO:0000269|PubMed:16615890}.
CC -!- INTERACTION:
CC Q92358; Q9US52: bqt2; NbExp=6; IntAct=EBI-929655, EBI-929651;
CC Q92358; Q09825: sad1; NbExp=4; IntAct=EBI-929655, EBI-929731;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, spindle pole body. Chromosome, telomere. Note=Colocalizes with
CC the telomere cluster during the 'horsetail' stage and then disappears
CC before the first meiotic division.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB232930; BAE80118.1; -; Genomic_DNA.
DR EMBL; CU329670; CAK10697.1; -; Genomic_DNA.
DR PIR; T39075; T39075.
DR RefSeq; XP_001713078.1; XM_001713026.2.
DR AlphaFoldDB; Q92358; -.
DR BioGRID; 278458; 16.
DR IntAct; Q92358; 3.
DR STRING; 4896.SPAC6G9.13c.1; -.
DR PaxDb; Q92358; -.
DR EnsemblFungi; SPAC6G9.13c.1; SPAC6G9.13c.1:pep; SPAC6G9.13c.
DR PomBase; SPAC6G9.13c; bqt1.
DR VEuPathDB; FungiDB:SPAC6G9.13c; -.
DR HOGENOM; CLU_1918310_0_0_1; -.
DR OMA; EFRIHYY; -.
DR PRO; PR:Q92358; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0140445; C:chromosome, telomeric repeat region; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0110092; C:nucleus leading edge; IDA:PomBase.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IPI:PomBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032121; P:meiotic attachment of telomeric heterochromatin to spindle pole body; IMP:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:PomBase.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Chromosome; Chromosome partition; Cytoplasm;
KW Cytoskeleton; Meiosis; Reference proteome; Telomere.
FT CHAIN 1..132
FT /note="Telomere bouquet protein 1"
FT /id="PRO_0000116629"
SQ SEQUENCE 132 AA; 15672 MW; 03E082A24921F62A CRC64;
MHLLTTTLIS FEQNKVEYLT QIAIYTQTPV CTDSNCEHAR FLKHSLIQVS IERIEYLYSI
FPNIWQFALL CQGQNKESLI HMEEDASTNF KLRYYVLPWS RRLQGYQSIT VQNGSHVPLV
KRLEKWRIFV EC
