ID   TCPB_ARATH              Reviewed;         527 AA.
AC   Q940P8;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=T-complex protein 1 subunit beta {ECO:0000303|PubMed:11599560};
DE            Short=TCP-1-beta {ECO:0000303|PubMed:11599560};
DE   AltName: Full=CCT-beta {ECO:0000303|PubMed:11599560};
DE   AltName: Full=Chaperonin CCT2 {ECO:0000305};
GN   Name=CCT2 {ECO:0000305};
GN   OrderedLocusNames=At5g20890 {ECO:0000312|Araport:AT5G20890};
GN   ORFNames=F22D1.60 {ECO:0000312|EMBL:AAL06871.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL06871.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, NOMENCLATURE, AND SUBUNIT.
RX   PubMed=11599560; DOI=10.1379/1466-1268(2001)006<0190:attiai>2.0.co;2;
RA   Hill J.E., Hemmingsen S.M.;
RT   "Arabidopsis thaliana type I and II chaperonins.";
RL   Cell Stress Chaperones 6:190-200(2001).
CC   -!- FUNCTION: Molecular chaperone; assists the folding of proteins upon ATP
CC       hydrolysis. Known to play a role, in vitro, in the folding of actin and
CC       tubulin. {ECO:0000305}.
CC   -!- SUBUNIT: Heterooligomeric complex of about 850 to 900 kDa that forms
CC       two stacked rings, 12 to 16 nm in diameter.
CC       {ECO:0000305|PubMed:11599560}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family.
CC       {ECO:0000255|RuleBase:RU004187}.
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DR   EMBL; AF296834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED92901.1; -; Genomic_DNA.
DR   EMBL; AY054210; AAL06871.1; -; mRNA.
DR   EMBL; AY062651; AAL32729.1; -; mRNA.
DR   EMBL; AY085104; AAM61658.1; -; mRNA.
DR   EMBL; BT002090; AAN72101.1; -; mRNA.
DR   RefSeq; NP_197589.1; NM_122097.3.
DR   AlphaFoldDB; Q940P8; -.
DR   SMR; Q940P8; -.
DR   IntAct; Q940P8; 5.
DR   STRING; 3702.AT5G20890.1; -.
DR   iPTMnet; Q940P8; -.
DR   PaxDb; Q940P8; -.
DR   PRIDE; Q940P8; -.
DR   ProMEX; Q940P8; -.
DR   ProteomicsDB; 234208; -.
DR   EnsemblPlants; AT5G20890.1; AT5G20890.1; AT5G20890.
DR   GeneID; 832213; -.
DR   Gramene; AT5G20890.1; AT5G20890.1; AT5G20890.
DR   KEGG; ath:AT5G20890; -.
DR   Araport; AT5G20890; -.
DR   TAIR; locus:2147132; AT5G20890.
DR   eggNOG; KOG0363; Eukaryota.
DR   HOGENOM; CLU_008891_6_2_1; -.
DR   InParanoid; Q940P8; -.
DR   OMA; YCTGGEI; -.
DR   OrthoDB; 335406at2759; -.
DR   PhylomeDB; Q940P8; -.
DR   BRENDA; 3.6.4.B10; 399.
DR   PRO; PR:Q940P8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q940P8; baseline and differential.
DR   Genevisible; Q940P8; AT.
DR   GO; GO:0046658; C:anchored component of plasma membrane; HDA:TAIR.
DR   GO; GO:0005832; C:chaperonin-containing T-complex; IBA:GO_Central.
DR   GO; GO:0009505; C:plant-type cell wall; HDA:TAIR.
DR   GO; GO:0009536; C:plastid; HDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   CDD; cd03336; TCP1_beta; 1.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR012716; Chap_CCT_beta.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   PANTHER; PTHR11353:SF206; PTHR11353:SF206; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00304; TCOMPLEXTCP1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   SUPFAM; SSF54849; SSF54849; 1.
DR   TIGRFAMs; TIGR02341; chap_CCT_beta; 1.
DR   PROSITE; PS00750; TCP1_1; 1.
DR   PROSITE; PS00751; TCP1_2; 1.
DR   PROSITE; PS00995; TCP1_3; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..527
FT                   /note="T-complex protein 1 subunit beta"
FT                   /id="PRO_0000431659"
SQ   SEQUENCE   527 AA;  57286 MW;  658AEB52BD49B9EA CRC64;
     MPIDKIFKDD ASEEKGERAR MASFVGAMAI SDLVKSTLGP KGMDKILQST GRGHAVTVTN
     DGATILKSLH IDNPAAKVLV DISKVQDDEV GDGTTSVVVL AGELLREAEK LVASKIHPMT
     IIAGYRMASE CARNALLKRV IDNKDNAEKF RSDLLKIAMT TLCSKILSQD KEHFAEMAVD
     AVFRLKGSTN LEAIQIIKKP GGSLKDSFLD EGFILDKKIG IGQPKRIENA NILVANTAMD
     TDKVKIYGAR VRVDSMTKVA EIEGAEKEKM KDKVKKIIGH GINCFVNRQL IYNFPEELFA
     DAGILAIEHA DFEGIERLGL VTGGEIASTF DNPESVKLGH CKLIEEIMIG EDKLIHFSGC
     EMGQACSIVL RGASHHVLDE AERSLHDALC VLSQTVNDTR VLLGGGWPEM VMAKEVDELA
     RKTAGKKSHA IEAFSRALVA IPTTIADNAG LDSAELVAQL RAEHHTEGCN AGIDVITGAV
     GDMEERGIYE AFKVKQAVLL SATEASEMIL RVDEIITCAP RRREDRM