BQT2_SCHPO
ID BQT2_SCHPO Reviewed; 118 AA.
AC Q9US52; Q2ABX3;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Telomere bouquet protein 2;
DE AltName: Full=Meiotic chromosome segregation protein bqt2;
DE AltName: Full=Meiotically up-regulated gene 18 protein;
GN Name=bqt2; Synonyms=mug18; ORFNames=SPAC1002.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INTERACTION WITH BQT1, AND
RP SUBCELLULAR LOCATION.
RX PubMed=16615890; DOI=10.1016/j.cell.2006.01.048;
RA Chikashige Y., Tsutsumi C., Yamane M., Okamasa K., Haraguchi T.,
RA Hiraoka Y.;
RT "Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet
RT arrangement of chromosomes.";
RL Cell 125:59-69(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in chromosome segregation. During meiotic prophase,
CC connects telomeres to the spindle pole body by forming a bridge between
CC the telomere protein rap1 and the spindle pole body protein sad1.
CC {ECO:0000269|PubMed:16303567, ECO:0000269|PubMed:16615890}.
CC -!- SUBUNIT: Interacts with bqt1. The bqt1-bqt2-sad1 complex binds rap1.
CC {ECO:0000269|PubMed:16615890}.
CC -!- INTERACTION:
CC Q9US52; Q92358: bqt1; NbExp=6; IntAct=EBI-929651, EBI-929655;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton,
CC microtubule organizing center, spindle pole body. Chromosome, telomere.
CC Note=Colocalizes with the telomere cluster during the 'horsetail' stage
CC and then disappears before the first meiotic division.
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DR EMBL; AB232931; BAE80119.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB65606.1; -; Genomic_DNA.
DR RefSeq; NP_593493.1; NM_001018927.1.
DR AlphaFoldDB; Q9US52; -.
DR BioGRID; 279701; 5.
DR IntAct; Q9US52; 3.
DR STRING; 4896.SPAC1002.06c.1; -.
DR PaxDb; Q9US52; -.
DR EnsemblFungi; SPAC1002.06c.1; SPAC1002.06c.1:pep; SPAC1002.06c.
DR GeneID; 2543273; -.
DR KEGG; spo:SPAC1002.06c; -.
DR PomBase; SPAC1002.06c; bqt2.
DR VEuPathDB; FungiDB:SPAC1002.06c; -.
DR HOGENOM; CLU_2159869_0_0_1; -.
DR OMA; WWIAEQV; -.
DR PRO; PR:Q9US52; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0140445; C:chromosome, telomeric repeat region; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
DR GO; GO:0110092; C:nucleus leading edge; IDA:PomBase.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IPI:PomBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032121; P:meiotic attachment of telomeric heterochromatin to spindle pole body; IMP:PomBase.
DR GO; GO:0045141; P:meiotic telomere clustering; IMP:PomBase.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Chromosome; Chromosome partition; Cytoplasm;
KW Cytoskeleton; Meiosis; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..118
FT /note="Telomere bouquet protein 2"
FT /id="PRO_0000116801"
SQ SEQUENCE 118 AA; 13688 MW; 29331F2A72640933 CRC64;
MFQGKCAFFD ETVPSALIAL WQLHNGEAKF LAEGYENFDY AFSMHLRKHV RLPNYKSVQC
RSPWWIAEQV AVSRSKSYVS EPVIHLNVME PLYVDHRIRS VYLQPLPSTL SFLNGELP
