ID   TCPB_VIBCH              Reviewed;         430 AA.
AC   P23476; Q56665;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 3.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Toxin coregulated pilus biosynthesis protein B;
DE   AltName: Full=TCP pilus biosynthesis protein TcpB;
GN   Name=tcpB; OrderedLocusNames=VC_0829;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Classical Inaba Z17561 / Serotype O1, and El Tor H1 / Serotype O1;
RX   PubMed=8621096; DOI=10.1016/0378-1119(95)00744-x;
RA   Ogierman M.A., Voss E., Meaney C., Faast R., Attridge S.R., Manning P.A.;
RT   "Comparison of the promoter proximal regions of the toxin-co-regulated tcp
RT   gene cluster in classical and El Tor strains of Vibrio cholerae O1.";
RL   Gene 170:9-16(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [3]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50.
RX   PubMed=2576015; DOI=10.1016/0378-1119(89)90486-1;
RA   Faast R., Ogierman M.A., Stroeher U.H., Manning P.A.;
RT   "Nucleotide sequence of the structural gene, tcpA, for a major pilin
RT   subunit of Vibrio cholerae.";
RL   Gene 85:227-231(1989).
CC   -!- FUNCTION: Involved in TCP pilus biogenesis.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X64098; CAA45456.1; -; Genomic_DNA.
DR   EMBL; X74730; CAA52746.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF93992.1; -; Genomic_DNA.
DR   EMBL; M33514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; JC4720; JC4720.
DR   RefSeq; NP_230477.1; NC_002505.1.
DR   RefSeq; WP_001234004.1; NZ_LT906614.1.
DR   AlphaFoldDB; P23476; -.
DR   STRING; 243277.VC_0829; -.
DR   DNASU; 2614496; -.
DR   EnsemblBacteria; AAF93992; AAF93992; VC_0829.
DR   KEGG; vch:VC_0829; -.
DR   PATRIC; fig|243277.26.peg.790; -.
DR   eggNOG; ENOG5031N69; Bacteria.
DR   HOGENOM; CLU_637675_0_0_6; -.
DR   OMA; EDSELCW; -.
DR   BioCyc; VCHO:VC0829-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..430
FT                   /note="Toxin coregulated pilus biosynthesis protein B"
FT                   /id="PRO_0000072464"
FT   REGION          351..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..370
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         93
FT                   /note="L -> P (in strain: Z17561)"
FT   VARIANT         202
FT                   /note="V -> A (in strain: Z17561)"
FT   VARIANT         254
FT                   /note="T -> S (in strain: Z17561)"
FT   VARIANT         266..267
FT                   /note="KS -> NA (in strain: Z17561)"
SQ   SEQUENCE   430 AA;  47119 MW;  3DCD382C5CBDC50F CRC64;
     MRKYQQGVGL LEAILASAVL GMALVAAGSY YKREAELMIK SSNAFDVIEL SSQIQRYASL
     SKINNRTNPI LKDNKAKEFK DADLKWLKLE NCLTAGDVPT TGNNNDLQDQ FIACDADYRK
     GDLSYFGSQF EFSTYVHPSN PEIQRQIKQV VSYFQYRGME RAFIGDAAGY VISEAKKKGF
     SAQDYRIVLI EPDRVGYFES NVISYEEFIE NPSARENFLL KATKDRTLAL AVSLAQTGEI
     AMQRDGSVAF LEDTELCWDT AAGSAKSCLS VRYDTVGNKT ELDLKQIDVV SAKGLSFESD
     GKTKTPVVST YETFQDGGRA KTINAIECPT GLNNRFAAVV SSFSTAGQNA NFSSESAKDS
     QGTTQKDGSK GPHALLSGIS LNWTLTNKVW DVTASIGIES GILPTSGIDS GSLLRNPKSL
     SFIAFQWCEN