ID   TCPC_VIBCH              Reviewed;         489 AA.
AC   P29481; Q56667; Q9KTR3;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Toxin coregulated pilus biosynthesis outer membrane protein C;
DE   AltName: Full=TCP pilus biosynthesis protein TcpC;
DE   Flags: Precursor;
GN   Name=tcpC; OrderedLocusNames=VC_0831;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Classical Inaba Z17561 / Serotype O1;
RX   PubMed=1358749; DOI=10.1016/0378-1097(92)90383-y;
RA   Ogierman M.A., Manning P.A.;
RT   "TCP pilus biosynthesis in Vibrio cholerae O1: gene sequence of tcpC
RT   encoding an outer membrane lipoprotein.";
RL   FEMS Microbiol. Lett. 76:179-184(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
RC   STRAIN=El Tor H1 / Serotype O1;
RX   PubMed=8621096; DOI=10.1016/0378-1119(95)00744-x;
RA   Ogierman M.A., Voss E., Meaney C., Faast R., Attridge S.R., Manning P.A.;
RT   "Comparison of the promoter proximal regions of the toxin-co-regulated tcp
RT   gene cluster in classical and El Tor strains of Vibrio cholerae O1.";
RL   Gene 170:9-16(1996).
CC   -!- FUNCTION: Involved in TCP pilus biogenesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor.
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DR   EMBL; X64098; CAA45458.1; -; Genomic_DNA.
DR   EMBL; AE003852; AAF93994.1; -; Genomic_DNA.
DR   EMBL; X74730; CAA52748.1; -; Genomic_DNA.
DR   PIR; B82275; B82275.
DR   PIR; PC4162; PC4162.
DR   PIR; S23267; S23267.
DR   RefSeq; NP_230479.1; NC_002505.1.
DR   RefSeq; WP_000750979.1; NZ_LT906614.1.
DR   AlphaFoldDB; P29481; -.
DR   STRING; 243277.VC_0831; -.
DR   DNASU; 2614498; -.
DR   EnsemblBacteria; AAF93994; AAF93994; VC_0831.
DR   GeneID; 57739534; -.
DR   KEGG; vch:VC_0831; -.
DR   PATRIC; fig|243277.26.peg.792; -.
DR   eggNOG; COG4796; Bacteria.
DR   HOGENOM; CLU_563760_0_0_6; -.
DR   OMA; ESSFWDD; -.
DR   BioCyc; VCHO:VC0831-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           17..489
FT                   /note="Toxin coregulated pilus biosynthesis outer membrane
FT                   protein C"
FT                   /id="PRO_0000018196"
FT   TRANSMEM        174..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   LIPID           17
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           17
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        15
FT                   /note="S -> A (in Ref. 1; CAA45458)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        32
FT                   /note="S -> N (in Ref. 1; CAA45458)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        43
FT                   /note="A -> R (in Ref. 1; CAA45458)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        108
FT                   /note="N -> K (in Ref. 1; CAA45458)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        204
FT                   /note="E -> K (in Ref. 1; CAA45458)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   489 AA;  53890 MW;  5849CEFAEA23717B CRC64;
     MKKTIISTLV IGLVSGCSNT NLLKDNLASE QSVINLSKSS NEAKSRNIEF LSGAYLSERK
     VPKHDIKFSG KYVEFESKSP IELIDVLDGL SKQYNIQYVF SDELEDENSE ENKKSSGSSS
     AKKIKYSGPL AGFFDYLSSA YNMHFEFGHN NLVKAYHYKN QVFNLQQYFD DNKFSSSMQI
     GGTSGTSSGL KGTADTAIES NSWEKIDEFL SASLGETGKF TIFEDYSLVT VKARPDKFLL
     LHTFFDKLIN ESKMQIAVDY RVVSLSEERL NQLAAKFGIE NAGKYSITSD MVDAISLSQV
     GGGLGASYRS ASARLDAVVN ELSQEVMHEG HFIGIPNRVM PLNVTTNSKY ISSIETTKDT
     NTDEETRTVK VSDLVTGFSM MVMPKILDDG RIQISSGFSR KQLVSIGTAQ GITLPTVDEN
     ESMNTVTMNP GEVRLAMLFK DNYIQNSNGV QLLGGGTENK KSARYIAVLV GASSYKTNDL
     ASNRVNIYD