ID   TCPD_VIBCH              Reviewed;         278 AA.
AC   P29491; Q9KTR2;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Toxin coregulated pilus biosynthesis protein D;
DE   AltName: Full=TCP pilus biosynthesis protein TcpD;
GN   Name=tcpD; OrderedLocusNames=VC_0833;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Classical Inaba Z17561 / Serotype O1;
RX   PubMed=8097178; DOI=10.1016/0378-1119(93)90589-u;
RA   Ogierman M.A., Zabihi S., Mourtzios L., Manning P.A.;
RT   "Genetic organization and sequence of the promoter-distal region of the tcp
RT   gene cluster of Vibrio cholerae.";
RL   Gene 126:51-60(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Involved in TCP pilus biogenesis.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA45460.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X64098; CAA45460.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE003852; AAF93996.1; -; Genomic_DNA.
DR   PIR; D82275; D82275.
DR   RefSeq; NP_230481.1; NC_002505.1.
DR   RefSeq; WP_001880631.1; NZ_LT906614.1.
DR   AlphaFoldDB; P29491; -.
DR   STRING; 243277.VC_0833; -.
DR   PRIDE; P29491; -.
DR   DNASU; 2614500; -.
DR   EnsemblBacteria; AAF93996; AAF93996; VC_0833.
DR   GeneID; 57739535; -.
DR   KEGG; vch:VC_0833; -.
DR   PATRIC; fig|243277.26.peg.794; -.
DR   eggNOG; ENOG5031NZT; Bacteria.
DR   HOGENOM; CLU_1000937_0_0_6; -.
DR   OMA; NGNECNI; -.
DR   BioCyc; VCHO:VC0833-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..278
FT                   /note="Toxin coregulated pilus biosynthesis protein D"
FT                   /id="PRO_0000072465"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        79
FT                   /note="D -> A (in Ref. 1; CAA45460)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   278 AA;  32276 MW;  B789FA7EB21357AE CRC64;
     MVNVIMKISS LKKGSNFSIN IKNIKLDKKL LVAIIFLVLS ILGGGAYLYY ENEKTKKLEQ
     ARLQKIQKEN SDKQTYLSDF KSAFEGLDYQ ALTGFYDVLR SDIDFFRVNN WLLDVMDCNV
     NCNLAFKRGS FDTFTYLEMN RNGAVIKPQF DQNKLQFANV DYISGFRSIY LKDLTEQERD
     KSENIIEQCS TKLSELYNLQ LLMKEQVKFK INLPRNVTSI SGYDWVKNSD IKFGSIEIEN
     MPEKNLGLMK NIMNNSMMIT SISLQNSSFK SKLNYYCY