ID   TCPF_VIBC3              Reviewed;         338 AA.
AC   A5F383; C3LYK2; P29488; Q9KTQ9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Toxin coregulated pilus biosynthesis protein F;
DE   AltName: Full=TCP pilus biosynthesis protein TcpF;
DE   Flags: Precursor;
GN   Name=tcpF; OrderedLocusNames=VC0395_A0362, VC395_0853;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11179381; DOI=10.1128/iai.69.3.1947-1952.2001;
RA   Karaolis D.K.R., Lan R., Kaper J.B., Reeves P.R.;
RT   "Comparison of Vibrio cholerae pathogenicity islands in sixth and seventh
RT   pandemic strains.";
RL   Infect. Immun. 69:1947-1952(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Involved in TCP pilus biogenesis. May be a channel protein
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Peripheral
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AF325733; AAK20764.1; -; Genomic_DNA.
DR   EMBL; CP000627; ABQ22146.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP08868.1; -; Genomic_DNA.
DR   RefSeq; WP_001269569.1; NZ_JAACZH010000023.1.
DR   AlphaFoldDB; A5F383; -.
DR   SMR; A5F383; -.
DR   STRING; 345073.VC395_0853; -.
DR   EnsemblBacteria; ABQ22146; ABQ22146; VC0395_A0362.
DR   KEGG; vco:VC0395_A0362; -.
DR   KEGG; vcr:VC395_0853; -.
DR   PATRIC; fig|345073.21.peg.825; -.
DR   HOGENOM; CLU_839222_0_0_6; -.
DR   OMA; KPYQPSD; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.3240; -; 1.
DR   InterPro; IPR009405; TcpF.
DR   InterPro; IPR043125; TcpF_C.
DR   Pfam; PF06340; TcpF; 1.
DR   PIRSF; PIRSF020763; TcpF; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..338
FT                   /note="Toxin coregulated pilus biosynthesis protein F"
FT                   /id="PRO_0000324785"
SQ   SEQUENCE   338 AA;  38211 MW;  82D6E9B660506939 CRC64;
     MRYKKTLMLS IMITSFNSFA FNDNYSSTST VYATSNEATD SRGSEHLRYP YLECIKIGMS
     RDYLENCVKV SFPTSQDMFY DAYPSTESDG AKTRTKEDFS ARLLAGDYDS LQKLYIDFYL
     AQTTFDWEIP TRDQIETLVN YANEGKLSTA LNQEYITGRF LTKENGRYDI VNVGGVPDNT
     PVKLPAIVSK RGLMGTTSVV NAIPNEIYPH IKVYEGTLSR LKPGGAMIAV LEYDVNELSK
     HGYTNLWDVQ FKVLVGVPHA ETGVIYDPVY EETVKPYQPS NNLTGKKLYN VSTNDMHNGY
     KWSNTMFSNS NYKTQILLTK GDGSGVKLYS KAYSENFK