TCPG_ARATH
ID TCPG_ARATH Reviewed; 555 AA.
AC Q84WV1; O81503;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=T-complex protein 1 subunit gamma {ECO:0000303|PubMed:11599560};
DE Short=TCP-1-gamma {ECO:0000303|PubMed:11599560};
DE AltName: Full=CCT-gamma {ECO:0000303|PubMed:11599560};
DE AltName: Full=Chaperonin CCT3 {ECO:0000303|PubMed:21868675};
GN Name=CCT3 {ECO:0000303|PubMed:21868675};
GN OrderedLocusNames=At5g26360 {ECO:0000312|Araport:AT5G26360};
GN ORFNames=F9D12.18 {ECO:0000312|EMBL:AAC26244.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAO22566.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND SUBUNIT.
RX PubMed=11599560; DOI=10.1379/1466-1268(2001)006<0190:attiai>2.0.co;2;
RA Hill J.E., Hemmingsen S.M.;
RT "Arabidopsis thaliana type I and II chaperonins.";
RL Cell Stress Chaperones 6:190-200(2001).
RN [5]
RP DISRUPTION PHENOTYPE, AND INTERACTION WITH CCT8.
RX PubMed=21868675; DOI=10.1126/science.1205727;
RA Xu X.M., Wang J., Xuan Z., Goldshmidt A., Borrill P.G., Hariharan N.,
RA Kim J.Y., Jackson D.;
RT "Chaperonins facilitate KNOTTED1 cell-to-cell trafficking and stem cell
RT function.";
RL Science 333:1141-1144(2011).
CC -!- FUNCTION: Molecular chaperone; assists the folding of proteins upon ATP
CC hydrolysis. Known to play a role, in vitro, in the folding of actin and
CC tubulin. {ECO:0000305}.
CC -!- SUBUNIT: Heterooligomeric complex of about 850 to 900 kDa that forms
CC two stacked rings, 12 to 16 nm in diameter (PubMed:11599560). Interacts
CC with CCT8 (PubMed:21868675). {ECO:0000269|PubMed:21868675,
CC ECO:0000305|PubMed:11599560}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethal. {ECO:0000269|PubMed:21868675}.
CC -!- SIMILARITY: Belongs to the TCP-1 chaperonin family.
CC {ECO:0000255|RuleBase:RU004187}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC26244.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF077407; AAC26244.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED93554.1; -; Genomic_DNA.
DR EMBL; BT002737; AAO22566.1; -; mRNA.
DR PIR; T01855; T01855.
DR RefSeq; NP_198008.1; NM_122537.4.
DR AlphaFoldDB; Q84WV1; -.
DR SMR; Q84WV1; -.
DR IntAct; Q84WV1; 11.
DR STRING; 3702.AT5G26360.1; -.
DR iPTMnet; Q84WV1; -.
DR MetOSite; Q84WV1; -.
DR SwissPalm; Q84WV1; -.
DR PaxDb; Q84WV1; -.
DR PRIDE; Q84WV1; -.
DR ProteomicsDB; 234166; -.
DR EnsemblPlants; AT5G26360.1; AT5G26360.1; AT5G26360.
DR GeneID; 832705; -.
DR Gramene; AT5G26360.1; AT5G26360.1; AT5G26360.
DR KEGG; ath:AT5G26360; -.
DR Araport; AT5G26360; -.
DR TAIR; locus:2151084; AT5G26360.
DR eggNOG; KOG0364; Eukaryota.
DR HOGENOM; CLU_008891_7_3_1; -.
DR InParanoid; Q84WV1; -.
DR OMA; RYCRIEK; -.
DR OrthoDB; 391677at2759; -.
DR PhylomeDB; Q84WV1; -.
DR BRENDA; 3.6.4.B10; 399.
DR PRO; PR:Q84WV1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q84WV1; baseline and differential.
DR Genevisible; Q84WV1; AT.
DR GO; GO:0005832; C:chaperonin-containing T-complex; IBA:GO_Central.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR CDD; cd03337; TCP1_gamma; 1.
DR Gene3D; 1.10.560.10; -; 1.
DR Gene3D; 3.30.260.10; -; 1.
DR Gene3D; 3.50.7.10; -; 1.
DR InterPro; IPR012719; Chap_CCT_gamma.
DR InterPro; IPR017998; Chaperone_TCP-1.
DR InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR InterPro; IPR027413; GROEL-like_equatorial_sf.
DR InterPro; IPR027410; TCP-1-like_intermed_sf.
DR PANTHER; PTHR11353; PTHR11353; 1.
DR Pfam; PF00118; Cpn60_TCP1; 1.
DR PRINTS; PR00304; TCOMPLEXTCP1.
DR SUPFAM; SSF48592; SSF48592; 1.
DR SUPFAM; SSF52029; SSF52029; 1.
DR SUPFAM; SSF54849; SSF54849; 1.
DR TIGRFAMs; TIGR02344; chap_CCT_gamma; 1.
DR PROSITE; PS00750; TCP1_1; 1.
DR PROSITE; PS00751; TCP1_2; 1.
DR PROSITE; PS00995; TCP1_3; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT CHAIN 1..555
FT /note="T-complex protein 1 subunit gamma"
FT /id="PRO_0000431660"
FT REGION 527..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 60339 MW; DB49A763491F4A83 CRC64;
MHAPVLVLSD SLKRESGSKV HHGNIQASKA VADIIRTTLG PRSMLKMLLD AGGGIVVTND
GNAILRELDV AHPAAKSMIE LSRTQDEEVG DGTTSVIVLA GEMLHVAEAF LEKNYHPTVI
CRAYIKALED SIAVLDKIAM SIDINDRSQV LGLVKSCIGT KFTSQFGDLI ADLAIDATTT
VGVDLGQGLR EVDIKKYIKV EKVPGGQFED SEVLKGVMFN KDVVAPGKMK RKIVNPRIIL
LDCPLEYKKG ENQTNAELVR EEDWEVLLKL EEEYIENICV QILKFKPDLV ITEKGLSDLA
CHYFSKAGVS AIRRLRKTDN NRIAKACGAV IVNRPDELQE SDIGTGAGLF EVKKIGDDFF
SFIVDCKEPK ACTVLLRGPS KDFINEVERN LQDAMSVARN IIKNPKLVPG GGATELTVSA
TLKQKSATIE GIEKWPYEAA AIAFEAIPRT LAQNCGVNVI RTMTALQGKH ANGENAWTGI
DGNTGAIADM KESKIWDSYN VKAQTFKTAI EAACMLLRID DIVSGIKKKQ APGSGPSKPT
IETEGDADNE QILPD
