ID   TCPG_ENCCU              Reviewed;         519 AA.
AC   Q8SR76;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=T-complex protein 1 subunit gamma;
DE            Short=TCP-1-gamma;
DE   AltName: Full=CCT-gamma;
GN   Name=CCT3; OrderedLocusNames=ECU10_0240;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Molecular chaperone; assists the folding of proteins upon ATP
CC       hydrolysis. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the T-complex protein 1 (TCP1) complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL590449; CAD25743.1; -; Genomic_DNA.
DR   RefSeq; NP_586139.1; NM_001041972.1.
DR   AlphaFoldDB; Q8SR76; -.
DR   SMR; Q8SR76; -.
DR   STRING; 284813.Q8SR76; -.
DR   PRIDE; Q8SR76; -.
DR   GeneID; 859787; -.
DR   KEGG; ecu:ECU10_0240; -.
DR   VEuPathDB; MicrosporidiaDB:ECU10_0240; -.
DR   HOGENOM; CLU_008891_7_3_1; -.
DR   InParanoid; Q8SR76; -.
DR   OMA; RYCRIEK; -.
DR   OrthoDB; 391677at2759; -.
DR   Proteomes; UP000000819; Chromosome X.
DR   GO; GO:0005832; C:chaperonin-containing T-complex; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR   CDD; cd03337; TCP1_gamma; 1.
DR   Gene3D; 1.10.560.10; -; 1.
DR   Gene3D; 3.30.260.10; -; 1.
DR   Gene3D; 3.50.7.10; -; 1.
DR   InterPro; IPR012719; Chap_CCT_gamma.
DR   InterPro; IPR017998; Chaperone_TCP-1.
DR   InterPro; IPR002194; Chaperonin_TCP-1_CS.
DR   InterPro; IPR002423; Cpn60/GroEL/TCP-1.
DR   InterPro; IPR027409; GroEL-like_apical_dom_sf.
DR   InterPro; IPR027413; GROEL-like_equatorial_sf.
DR   InterPro; IPR027410; TCP-1-like_intermed_sf.
DR   PANTHER; PTHR11353; PTHR11353; 1.
DR   Pfam; PF00118; Cpn60_TCP1; 1.
DR   PRINTS; PR00304; TCOMPLEXTCP1.
DR   SUPFAM; SSF48592; SSF48592; 1.
DR   SUPFAM; SSF52029; SSF52029; 1.
DR   SUPFAM; SSF54849; SSF54849; 1.
DR   TIGRFAMs; TIGR02344; chap_CCT_gamma; 1.
DR   PROSITE; PS00750; TCP1_1; 1.
DR   PROSITE; PS00751; TCP1_2; 1.
DR   PROSITE; PS00995; TCP1_3; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Chaperone; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..519
FT                   /note="T-complex protein 1 subunit gamma"
FT                   /id="PRO_0000379506"
SQ   SEQUENCE   519 AA;  57442 MW;  759D25A8BF3CAB27 CRC64;
     MQKPIPRKMY ILVPDKPAQI QNESAIAAKT ISSVIRTCLG PRAMQKMVLT KINSIELTND
     GNAILRELDV AHPSARSLIE LAKTQDDEVG DGTTSVVLLA AEILNEMTYI LDRDVHPIRI
     CKALGRALEI CIKAIDGAAI SLDSNEETKI KIINGSVASK ICNILKVPIG NLALEAVKKV
     YVKEENKCDL KNNMKVEKVL GGNLMESEVV DGVLINKDII HPQMRRVIEN PRIVIIESPL
     EYKKGESQTN YEFSKENDFT RALEIEEEQV REMCERIIGV RPDIVVCEKG ISDLALSILF
     ENNITGLRRL KKTDISRLSK VCGARSVSRP EDLEERHVGV SCGLFEYIKY GEEYYCKFSR
     CAHPKACSVV IRGPTKDILD ELERNFMDAV KVAKSIFISP KLCPGGGAAE MAMAHELMQS
     AGDNEVEAEV FSRMASALTI IPSILLENSG VFNPLEAITL LEQKHKEGSF YGVNGTTGEI
     VDTRDLVLEP YAVKSQCIKS AVEAVSQLLR IDGIIESKR